Body

The December 2009 issue of the Journal of General Physiology (JGP) contains a paper by Christopher Ahern (The University of British Columbia, Vancouver) and colleagues that explores pore mutation effects in Shaker and other K+ channels using in vivo nonsense suppression technology. The study will be published online November 16 (www.jgp.org).

Despite advances in treatment regimens and the best efforts of nurses and doctors, about 70% of all people with severe burns die from related infections. But a revolutionary new wound dressing developed at Tel Aviv University could cut that number dramatically.

Montreal, November 17, 2009 – More than six percent of expectant mothers in Quebec consume prescription drugs that are known to be harmful to their fetuses, according to a Université de Montréal investigation published in the British Journal of Obstetrics and Gynaecology. Half these women will voluntarily terminate their pregnancy fearing congenital malformations, which means the abortion rate among these women is 11 percent higher than in the rest of the population.

(PHILADELPHIA) Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion, according to two studies conducted at the Center for Translational Medicine at Thomas Jefferson University. The studies will be presented at the American Heart Association Scientific Sessions 2009 in Orlando, Fla.

BOSTON – (November 17, 2009) Tufts University researchers have identified a gene-diet interaction that appears to influence body weight and have replicated their findings in three independent studies. Men and women carrying the CC genotype demonstrated higher body mass index (BMI) scores and a higher incidence of obesity, but only if they consumed a diet high in saturated fat. These associations were seen in the apolipoprotein A-II gene (APOA2) promoter.

LOUISVILLE, Ky. – A new generation of implanted devices that help a failing heart function properly is significantly more effective than the previous version, making these new devices an appropriate permanent therapy for many of the more than 5 million Americans who suffer from heart failure.

Scientists from the Max Planck Institute (MPI) of Biochemistry in Martinsried near Munich, Germany, have now deciphered the mechanism that illustrates how these mobile cells move on diverse surfaces. "Similar to a car, these cells have an engine, a clutch and wheels which provide the necessary friction," explains Michael Sixt, a research group leader at the MPI of Biochemistry. The results, which were developed in cooperation with colleagues from the MPI for Metals Research in Stuttgart, Germany, have now been published in Nature Cell Biology.

The sensor of some optical mice can be used to easily and cheaply detect counterfeit euros, according to a study published by researchers of the University of Lleida (UdL) in the scientific journal Sensors. Almost 80% of counterfeit coins discovered in Europe in 2008 were two-euro coins.

Biologists at UC San Diego have discovered that honeybees can discriminate between food at different temperatures, an ability that may assist bees in locating the warm, sugar-rich nectar or high-protein pollen produced by many flowers.

Research into the controversial drug thalidomide reveals that the mechanism through which the drug causes limb defects is the same process which causes it to damage internal organs and other tissues. The article, published in Bio-Essays, outlines the challenges surrounding thalidomide research and claims that confirmation of a 'common mechanism' could lead to new treatments for Leprosy, Crohn's Disease, AIDS and some forms of cancer.

A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation.

The authors of the study, from Imperial College London, the Istituto Dermopatico dell'Immacolata in Rome and the Center of Allergy and Environment (ZAUM) in Munich, hope their discovery could lead to new treatments for these diseases that would bring the cells under control.

In one of the few studies of the long-term effects of medication in the treatment of pulmonary arterial hypertension (PAH) disease, a team of researchers found the health and exercise capacity of PAH patients improved after two years of treatment with ambrisentan, according to a study published in the current edition of the Journal of the American College of Cardiology.

Finding alternative feed sources for chickens, pigs and other farm animals will significantly reduce pressure on the world's dwindling fisheries while contributing positively to climate change, according to University of British Columbia researchers.

"Thirty million tons – or 36 per cent – of the world's total fisheries catch each year is currently ground up into fishmeal and oil to feed farmed fish, chickens and pigs," says UBC fisheries researcher Daniel Pauly, co-author of the Oryx: The International Journal of Conservation article, published online this week.

STANFORD, Calif. — Many patients with diabetes should forego angioplasties for heart disease and just take medicine instead, according to a new National Institutes of Health study led by Stanford University School of Medicine researcher Mark Hlatky, MD.

Researchers from Arizona State University have discovered that several species of microbes (cyanobacteria), at least one found prominently in the deserts of the Southwest, have evolved the trait of rope-building to lasso shifting soil substrates.