Body

Long-term survivors of testicular cancer who were treated with cisplatin-based chemotherapy had more severe side effects, including neurological side effects and Raynaud-like phenomena, than men who were not treated with chemotherapy, according to a new study published online November 25 in the Journal of the National Cancer Institute.

Researchers have found evidence of a statistically significant survival benefit from adjuvant tamoxifen among patients whose estrogen receptor (ER)-positive tumors had high levels of phosphorylation of ER-alpha; at serine-118 (ER-alpha S118-P), according to a brief communication published online November 25 in the Journal of the National Cancer Institute.

Approximately 50% of breast carcinomas are resistant to tamoxifen. Preclinical studies have shown that ER-alpha S118-P is required for response to tamoxifen.

Search the Internet to learn about your asthma, high cholesterol or other common disorder, and odds are you'll be directed to a pharmaceutical company-sponsored Web homepage. There you'll often find an offer for a free sample or a one-time discount on a top-selling prescription medication.

It is well known that some animal species use camouflage to hide from predators. Individuals that are able to blend in to their surroundings and avoid being eaten are able to survive longer, reproduce, and thus increase their fitness (pass along their genes to the next generation) compared to those who stand out more. This may seem like a good strategy, and fairly common in the animal kingdom, but who ever heard of a plant doing the same thing?

When cells are confronted with an invading virus or bacteria or exposed to an irritating chemical, they protect themselves by going off their DNA recipe and inserting the wrong amino acid into new proteins to defend them against damage, scientists have discovered.

Palo Alto— Photosynthetic organisms need to cope with a wide range of light intensities, which can change over timescales of seconds to minutes. Too much light can damage the photosynthetic machinery and cause cell death. Scientists at the Carnegie Institution were part of a team that found that specific proteins in algae can act as a safety valve to dissipate excess absorbed light energy before it can wreak havoc in cells.

HOUSTON - Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell.

The first genetic historical map of the Han Chinese, the largest ethnic population in the world, as they migrated from south to north over evolutionary time. was published online today by the American Journal of Human Genetics by scientists at the Genome Institute of Singapore (GIS).

Athens, Ga. – Bacteria don't have easy lives. In addition to mammalian immune systems that besiege the bugs, they have natural enemies called bacteriophages, viruses that kill half the bacteria on Earth every two days.

Still, bacteria and another class of microorganisms called archaea (first discovered in extreme environments such as deep-sea volcanic vents) manage just fine, thank you, in part because they have a built-in defense system that helps protect them from many viruses and other invaders.

DALLAS – Nov. 25, 2009 – Physicians at UT Southwestern Medical Center soon will begin implanting a new device designed to improve breathing in patients with upper spinal-cord injuries or other diseases that keep them from breathing independently.

UT Southwestern University Hospital – St. Paul is only one of only two sites in Texas and one of 25 in the country currently equipped to implant the device, called the NeuRx Diaphragm Pacing System.

Over the course of a lifetime, the heart pumps some 250 million liters of blood through the body. In the order to do this, the muscle fibers of the heart have to be extremely durable. The research group headed by Dr. Wolfgang Rottbauer, vice chair of the Department of Medicine III at Heidelberg University Hospital (Chairman: Prof. Dr. H. A. Katus), has discovered a protein that is responsible for the stability of the smallest muscular unit, the sarcomere.

Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of gastric cancers. Although their efficiencies in inhibiting the expression of HPA, the traditional HPA inhibitors may produce nonspecific and undesirable effects. In recent years, genetic approaches targeting HPA have been regarded as a promising alternative. Antisense oligonucleotides, ribozyme, and small RNA interference (siRNA) have been developed to decrease the HPA expression.

The gastric cardiac adenocarcinoma (GCA) is a very rare disease. In recent decades, however, the incidence of the GCA has increased dramatically in many Western countries. An increasing trend in GCA is also observed in municipal regions but not in rural regions of China. Another striking feature is the strong male predominance among patients with GCA. Some of the reasons above are still unclear and require further epidemiological investigations.

Dentists can help to identify patients who are in danger of dying of a heart attack or stroke, reveals a new study from the Sahlgrenska Academy. Thanks to the study, six men who thought they were completely healthy were able to start preventive treatment in time.

"Dentists are really proud of their profession and feel no need to encroach upon doctors' territory," says senior dental officer and professor Mats Jontell at the Sahlgrenska Academy. "However, we wanted to find out if we as a profession could identify patients at risk of cardiovascular disease."

LA JOLLA, CA—When you eat may be just as vital to your health as what you eat, found researchers at the Salk Institute for Biological Studies. Their experiments in mice revealed that the daily waxing and waning of thousands of genes in the liver—the body's metabolic clearinghouse—is mostly controlled by food intake and not by the body's circadian clock as conventional wisdom had it.