Body

COLUMBUS, Ohio – Adding low doses of the targeted agent sorafenib to the chemotherapy and radiation now often used to treat head and neck cancer might significantly improve patient care and quality of life, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James).

Chapel Hill, NC – An unusual collaboration between cell and developmental biologists and physicists at UNC-Chapel Hill is providing insights into the relationship between the physical properties of cells and the signals that influence cell behavior.

A variation in a gene involved in regulating cholesterol in the bloodstream also appears to affect progesterone production in women, making it a likely culprit in a substantial number of cases of their infertility, a new study from Johns Hopkins researchers suggests.

The Hopkins group has also developed a simple blood test for this variation of the scavenger receptor class B type 1 gene (SCARB1) but emphasized there is no approved therapy yet to address the problem in infertile women.

COLUMBUS, Ohio – The anti-inflammatory drug celecoxib, known by the brand name Celebrex, triggers liver cancer cell death by reacting with a protein in a way that makes those cells commit suicide, according to a new study.

Researchers also found that the combination of celecoxib with each of two chemotherapy drugs killed more liver cancer cells in culture, making those combinations more effective than either drug on its own.

ATS 2011, DENVER – Although so-called clot-busting drugs are commonly used in the treatment of some patients with blood clots in the lungs, a new study conducted by researchers in Spain and the U.S. indicates the agents do not appear to be any more effective than traditional blood thinners for the majority of these patients. Clot-busters, or thrombolytic agents, also appear to increase the risk of death in patients with normal blood pressure.

The study will be presented at the ATS 2011 International Conference in Denver.

ATS 2011, DENVER – Children with cystic fibrosis (CF) who have poor lung function early in life are more likely also to have poor lung function in adolescence, regardless of whether they are exposed to a common infection caused by the bacteria Pseudomonas aeruginosa in early childhood. Earlier studies had indicated infection with the bacteria early in life was strongly associated with poor lung function later on.

The study will be presented at the ATS 2011 International Conference in Denver.

ATS 2011, DENVER – Removing enlarged tonsils and adenoids may help prevent high blood pressure and heart damage in children who suffer from obstructive sleep apnea (OSA), according to a study conducted at Cincinnati Children's Hospital Medical Center. In some children with OSA, adenotonsillectomy can result in significantly lower blood pressure within 24 months of the procedure.

The results will be presented at the ATS 2011 International Conference in Denver.

Aggressive male mating behavior might well be a successful reproductive strategy for the individual but it can drive the species to extinction, an international research team headed by evolutionary biologist Daniel Rankin from the University of Zurich has demonstrated in a mathematical model.

Sophia Antipolis, France, Sunday 15 May 2011: The European Society of Cardiology (ESC) is calling for a single, co-ordinated European system to oversee the evaluation and approval of medical devices. The call is being made in a paper published online in the European Heart Journal reporting on a conference held by the ESC in January 2011 looking to increase the input of medical experts in developing medical device policy.

Stem cell research courts both controversy and support in the community- depending on your viewpoint.

Now, for the first time, scientists at Monash University's Immunology and Stem Cell Laboratories (MISCL) have shown that they can make human stem cells from healthy adult kidneys without working on human embryos, circumventing ethical concerns around this research.

With an increasingly warmer climate, there is a trend for springs to arrive earlier and summers to be hotter. Since spring and summer are the prime growing seasons for plants—when flowers bloom and trees increase in girth and height—do these climate changes mean greater seasonal growth for plants? This is a critical question for forest management, especially in the boreal region—an area particularly sensitive to the effects of climate change.

Scientists working with Professor Dr. Joachim L. Schultze have identified over 480 molecules whose concentration in the blood changes when a person develops lung cancer. These molecules are present in the blood cells either in increased or decreased quantities. "In lung cancer patients, typical patterns which can be detected with a measuring program thus emerge", explains Prof. Schultze. The molecules are nucleic acids which form in the body when certain genes are transcribed.

cientists have identified a class of naturally occurring bacteria that can strongly inhibit malaria-causing parasites in Anopheles mosquitoes, a finding that could have implications for efforts to control malaria. The study, led by George Dimopoulos, Ph.D., of the Bloomberg School of Public Health and the Malaria Research Institute, both of Johns Hopkins University, Baltimore, appears in the May 13 edition of Science. The research was partly funded by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health.

A research team has discovered that billions of years before life evolved in the oceans, thin layers of microbial matter in shallow water produced enough oxygen to support tiny, mobile life forms.

The researchers say worm-like creatures could have lived on the oxygen produced by photosynthetic microbial material, even though oxygen concentrations in the surrounding water were not high enough to support life. The research was conducted in shallow lagoons in Venezuela where the high salt content is comparable to oceans older than 500 million years.