Body

(Lebanon, NH, 6/11/13) — Subgroup analyses from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate, with capecitabine, a standard chemotherapy medication in women with previously treated metastatic breast cancer, showed increased benefit among women sharing certain traits. Specifically, these analyses demonstrated a greater potential benefit in certain subsets of patients with metastatic breast cancer. This analysis was presented by Peter A. Kaufman, M.D., during the 2013 ASCO Annual Meeting.

MINNEAPOLIS – Men who experience restless legs syndrome (RLS) may have a higher risk of dying earlier, according to research that appears in the June 12, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. The disorder is characterized by an irresistible urge to move the legs and often causes leg sensations of burning, creeping, and tugging, which are usually worse at night.

Researchers at the University of California, Berkeley, have developed an easier and more effective method for inserting genes into eye cells that could greatly expand gene therapy to help restore sight to patients with blinding diseases ranging from inherited defects like retinitis pigmentosa to degenerative illnesses of old age, such as macular degeneration.

Unlike current treatments, the new procedure – which takes a little as 15-minutes – is surgically non-invasive, and it delivers normal genes to difficult-to-reach cells throughout the entire retina.

PORTLAND, Ore. June 12, 2013. A recent study in the Journal of Forestry now offers managers a tool to help them identify regions exposed to multiple forest threats. The tool uses a novel 15-mile radius neighborhood analysis to highlight locations where threats are more concentrated relative to other areas, and identifies where multiple threats may intersect. It is a technique that may have never been used before to describe forest threats, according to the researchers.

Microbes are living more than 500 feet beneath the seafloor in 5 million-year-old sediment, according to new findings by researchers at the University of Delaware and Woods Hole Oceanographic Institution (WHOI).

Genetic material in mud from the bottom of the ocean — called the deep biosphere —revealed an ecosystem of active bacteria, fungi and other microscopic organisms at depths deeper than a skyscraper is high. The findings were published in Nature on June 12.

Bremerhaven, 12 June 2013. In collaboration with an international team of researchers, scientists at the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, have sequenced the genome of the calcified alga Emiliania huxleyi and have found an explanation for the enormous adaptive potential and global distribution of this unicellular alga. As the researchers report in an online prepublication of the scientific journal Nature, the microalga's "trick" is genetic diversity.

To World War II soldiers, "The White Cliffs of Dover" was a morale-boosting song that lifted spirits in dark times. To geographers, the white cliffs mark the point at which England is closest to continental Europe. To scientists, the white cliffs are towering structures made of the chalky, white shells that envelop the single-celled photosynthetic alga known as Emiliania huxleyi. "Ehux" is a coccolithophore, with an exoskeleton made of calcium carbonate.

The deep biosphere—the realm of sediments far below the seafloor—harbors a vast ecosystem of bacteria, archaea, and fungi that are actively metabolizing, proliferating, and moving, according a new study by scientists at Woods Hole Oceanographic Institution (WHOI) and the University of Delaware (UD).

"This is the first molecular evidence for active cell division in the deep biosphere," says Orsi. Previous studies and models had suggested cells were alive, but whether the cells were actually dividing or not had remained elusive.

Smaller than a speck of dust, Emiliania huxleyi plays an outsized role in the world's seas. Ranging from the polar oceans to the tropics, these free-floating photosynthetic algae remove carbon dioxide from the air, help supply the oxygen that we breathe, and form the base of marine food chains. When they proliferate, their massive turquoise blooms are visible from space.

Mammals possess the remarkable ability to regenerate a lost fingertip, including the nail, nerves and even bone. In humans, an amputated fingertip can sprout back in as little as two months, a phenomenon that has remained poorly understood until now. In a paper published today in the journal Nature, researchers at NYU Langone Medical Center shed light on this rare regenerative power in mammals, using genetically engineered mice to document for the first time the biochemical chain of events that unfolds in the wake of a fingertip amputation.

LIVERMORE, Calif.-- Lawrence Livermore National Laboratory researchers have broken the record for tracking the movement and concentration of carbon dioxide in a geologic formation using the world's deepest Electrical Resistance Tomography (ERT) system.

The research provides insight into the effects of geological sequestration to address the impact of greenhouse gases.

ROCHESTER, Minn. -- People who have obstructive sleep apnea -- when a person stops breathing for periods during sleep -- have a greater risk of sudden cardiac death, according to a study published online today in the Journal of the American College of Cardiology. An estimated 12 million American adults have obstructive sleep apnea, and many of them are undiagnosed, according to the National Heart, Lung and Blood Institute (NHLBI).

Pyrazinamide (PZA)—a frontline tuberculosis (TB) drug—kills dormant persister bacteria and plays a critical role in shortening TB therapy. PZA is used for treating both drug susceptible and multi-drug resistant TB (MDR-TB) but resistance to PZA occurs frequently and can compromise treatment.

Philadelphia, Pa. (June 12, 2013) – How will full implementation of the Affordable Care Act (ACA) affect the work and goals of state and local public health departments—and how can public health personnel contribute to the success of health care reform? The experience in Massachusetts has some important lessons, according to an article published online by the Journal of Public Health Management and Practice.

In World Oceans Month, there's mixed news for the Pacific Northwest oyster industry.

For the past several years, it has struggled with significant losses due to ocean acidification. Oyster larvae have had mortality rates high enough to render production no longer economically feasible.

Now a new study documents why oysters appear so sensitive to increasing acidity, but also offers some hope for the future.