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Extended treatment with combination medication for opioid-addicted youths shows benefit

Adolescents addicted to opioids who received continuing treatment with the combination medication buprenorphine-naloxone had lower rates of testing positive or reporting use of opioids compared to youths who went through a short-term detoxification program using the same medication, according to a study in the November 5 issue of JAMA.

Study shows testosterone improves sexual well-being in post-menopausal women

WHAT:An international study showed testosterone, when used with no other hormone therapy, is an effective treatment for low libido in postmenopausal women. More than 800 women from 65 centers in the United States, Canada, Australia, the United Kingdom and Sweden participated in the study, the first to show that testosterone administered by a skin patch can boost sex drive in postmenopausal women.

Age is not a key factor in cancer survival, but clinical trials exclude older patients

Age is not an independent factor in cancer survival rates and should not influence decisions about how to treat older patients, according to a study in the November issue of IJCP, the Independent Journal of Clinical Practice.

A team of hospital and University-based researchers from Barcelona, Spain, carried out a detailed study of more than 200 patients diagnosed with cancer.

MIT creates tiny backpacks for cells

CAMBRIDGE, Mass. -- MIT engineers have outfitted cells with tiny "backpacks" that could allow them to deliver chemotherapy agents, diagnose tumors or become building blocks for tissue engineering.

Michael Rubner, director of MIT's Center for Materials Science and Engineering and senior author of a paper on the work that appeared online in Nano Letters on Nov. 5, said he believes this is the first time anyone has attached such a synthetic patch to a cell.

Hormone therapy helps short children grow up

Chevy Chase, MD— Growth hormone treatment may significantly increase final height in children diagnosed with short stature, even in cases where the child is not growth hormone deficient, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Growth hormone (GH) has been shown to be effective in treating GH deficient children with short stature, but its effect on non GH deficient children with short stature has remained unclear.

Migraines associated with lower risk of breast cancer

SEATTLE – Women who suffer from migraines may take at least some comfort in a recent, first-of-its-kind study that suggests a history of such headaches is associated with a significantly lower risk of breast cancer. Christopher I. Li, M.D., Ph.D., and colleagues at Fred Hutchinson Cancer Research Center report these findings in the November issue of Cancer Epidemiology, Biomarkers and Prevention.

Coping and copulation behavior may help calculate diabetes risk

November 6, 2008, Cambridge, UK –Discussion of a man's background, attitude, and sexual history isn't just the fodder of Sex and The City episodes – in the future, it could also be a way of evaluating his risk of diabetes.

XDR-TB: Deadlier and more mysterious than ever

New research has found that XDR-TB is increasingly common and more deadly than previously known. Extensively drug-resistant tuberculosis (XDR-TB) is a growing public health threat that is only just beginning to be understood by medical and public health officials.

Study finds racial disparities increasing for cancers unrelated to smoking

ATLANTA— November 6, 2008—A new American Cancer Society study finds that recent progress in closing the gap in overall cancer mortality between African Americans and whites may be due primarily to smoking-related cancers, and that cancer mortality differences related to screening and treatment may still be increasing. The study, appearing in the November issue of Cancer Epidemiology Biomarkers and Prevention, is the first to analyze racial and ethnic differences between the two broad categories of disease.

Friendly bacteria reduce hospital infections

A probiotic bacterium, Lactobacillus plantarum 299, has been used to out-compete the dangerous bacteria that cause respiratory illness in ventilated patients. Research published in BioMed Central's open access journal Critical Care describes how applying a bacterial solution in place of normal antiseptics is effective in preventing the most common cause of ventilator-associated pneumonia (VAP).

Study reveals continued damage from banned obesity drug

Fenfluramine, the appetite suppressant drug banned in the US in 1997 due to fears over its links to heart conditions, has been shown to have serious long-term effects. In a report published today in the open access journal BMC Medicine, researchers have shown that people who stopped using fenfluramine eleven years ago had damaged heart valves up to seven years later.

DNA chunks, chimps and humans

Researchers have carried out the largest study of differences between human and chimpanzee genomes, identifying regions that have been duplicated or lost during evolution of the two lineages. The study, published in Genome Research, is the first to compare many human and chimpanzee genomes in the same fashion.

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

BERKELEY, CA -- A link between the immune system and the self-cleaning system by which biological cells rid themselves of obsolete or toxic parts may one day yield new weapons in the fight against tuberculosis and other deadly infectious diseases. Scientists with the U.S. Department of Energy's (DOE) Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered proteins residing in both systems that point to "cross-talk" between them.

Therapy may block expansion of breast cancer cells

Philadelphia, Penn. – November 05, 2008 – Breast cancer stem cells are known to be involved in therapy resistance and the recurrence of cancerous tumors. A new study appearing in Clinical and Translational Science shows the mechanisms governing stem cell expansion in breast cancer (called Notch activity), and finds that therapy targeting a protein called cyclin D1 may block the expansion of cancerous stem cells.

Reducing epidemic proportions

Hospitals are supposed to be havens for healing, but the numbers tell a different story. Too many people are infected by illnesses they acquire after they've been admitted, and hospital-related infections continue to be the number-two killer of hospitalized Americans after heart disease.

Now, a radical new high-tech software program developed by Tel Aviv University researchers to fight these infections is now catching on faster than the flu.