Body

African Americans experience longer delays between diagnosis and treatment of prostate cancer

Among men with prostate cancer, African Americans experience longer treatment delays after being diagnosed than Caucasians. That is the finding of an analysis published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The study suggests that efforts are needed to reduce racial disparities in prostate cancer care in order to provide earlier treatment for African Americans.

New approach may allow faster spinal anesthesia for cancer patients at end of life

San Francisco, CA. (May 28, 2013) – For patients with uncontrolled pain from terminal cancer, a new approach to calculating initial dosage may allow a quicker start of spinal analgesia—and less time in the hospital, according to a study in the June issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

Snail shell coiling programmed by protein patterning

Snail shells coil in response to an lopsided protein gradient across their shell mantles, finds research in BioMed Central's open access journal EvoDevo. In contrast the shell mantle of limpets, whose shells do not coil, have a symmetrical pattern of the protein Decapentaplegic (Dpp).

New safety test predicts reactions to novel drugs and cosmetics

A simple lab-based skin test which eliminates the risk of adverse reactions to new drugs, cosmetics and household chemicals has been developed by a Newcastle University, UK team.

It uses real human skin and immune cells to show any reaction such as a rash or blistering indicating a wider immune response within the body.

The development is timely as it offers a reliable alternative for the cosmetic industry as a ban on the sale of any cosmetic product tested on animals came into effect across Europe in March.

Meta-analysis: Bug and weed killers, solvents may increase risk of Parkinson's disease

MINNEAPOLIS – A large analysis of more than 100 studies from around the world shows that exposure to pesticides, or bug and weed killers, and solvents is likely associated with a higher risk of developing Parkinson's disease. The research appears in the May 28, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology.

Should you stop blood thinners before surgery? AAN guideline provides direction

MINNEAPOLIS – A new guideline from the American Academy of Neurology will help people who take blood thinners decide whether or not to take them during surgery or other medical procedures. The guideline is published in the May 28, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology.

How patient centered are medical decisions?

A national survey sample of adults who had discussions with their physicians in the preceding two years about common medical tests, medications and procedures often did not reflect a high level of shared decision making, according to an article published online by JAMA Internal Medicine.

Study examines placement of tobacco and alcohol brands in movies rated for youth audiences

An analysis of top box-office movies released in the United States indicated tobacco brand producer placements in movies have declined since implementation of the Master Settlement Agreement (MSA), but alcohol placements, which are subject only to industry self-regulation, have increased in movies rated acceptable for youth audiences, according to a study published Online First by JAMA Pediatrics, a JAMA Network publication.

Effective regulation of alcohol brand placements in movies could limit underage drinking

(Lebanon, NH, 5/27/2013) —Researchers at the Norris Cotton Cancer Center have found that current constraints on advertising for alcohol products in movies that adolescents watch are not effective.

The study, "Trends in Tobacco and Alcohol Brand Placements in Popular US movies, 1996 through 2009,"was published online in the May 27, 2013 JAMA Pediatrics.

UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies

Irvine, CA & Seattle, WA — Scientists at UC Irvine reported this week that a synthetic compound ShK-186, originally derived from a sea anemone toxin, has been found to enhance metabolic activity and shows potential as a treatment for obesity and insulin resistance.

KISS ME DEADLY proteins may help improve crop yields

Dartmouth College researchers have identified a new regulator for plant hormone signaling -- the KISS ME DEADLY family of proteins (KMDs) – that may help to improve production of fruits, vegetables and grains.

The study's results will be published the week of May 27 in the journal Proceedings of the National Academy of Sciences. Journalists can access the paper, titled "SCFKMD controls cytokinin signaling by regulating the degradation of type-B response regulators," through EurekAlert!.

All in one shot

Boston, MA – Developing new vaccines to protect against diseases that plague humans is fraught with numerous challenges—one being that microbes tend to vary how they look on the surface to avoid being identified and destroyed by the immune system. However, researchers from Brigham and Women's Hospital (BWH) have discovered a sugar polymer that is common on the cell surface of several pathogens. This common sugar molecule makes it a promising target for the development of a broad-spectrum vaccine that can protect against numerous deadly microbes expressing this sugar on their cell surface.

Salmonella uses protective switch during infection

RICHLAND, Wash. -- For the first time, researchers have found a particular kind of molecular switch in the food poisoning bacteria Salmonella Typhimurium under infection-like conditions. This switch, using a process called S-thiolation, appears to be used by the bacteria to respond to changes in the environment during infection and might protect it from harm, researchers report this week online in the Proceedings of the National Academy of Sciences Early Edition.

Even farm animal diversity is declining as accelerating species loss threatens humanity

The accelerating disappearance of Earth's species of both wild and domesticated plants and animals constitutes a fundamental threat to the well-being and even the survival of humankind, warns the founding Chair of a new global organization created to narrow the gulf between leading international biodiversity scientists and national policy-makers.

Stanford researchers identify genetic suspects in sporadic Lou Gehrig's disease

STANFORD, Calif. - Researchers at the Stanford University School of Medicine have identified mutations in several new genes that might be associated with the development of spontaneously occurring cases of the neurodegenerative disease known as amyotrophic lateral sclerosis, or ALS. Also known as Lou Gehrig's disease, the progressive, fatal condition, in which the motor neurons that control movement and breathing gradually cease to function, has no cure.