Body

Sleeping more than nine hours a night, and sitting too much during the day could be a hazardous combination, particularly when added to a lack of exercise, according to new findings to emerge from the Sax Institute's 45 and Up Study.

A combination of adult stem cells and parathyroid hormone significantly increased new bone formation in laboratory animals and may speed the healing process for human bone fractures caused by osteoporosis, a new study shows.

The study is published online by Molecular Therapy, a peer-reviewed journal in the Nature Publishing Group. Researchers used a combination of mesenchymal stem cells, which are derived from bone marrow taken from adults, and parathyroid hormone, also called PTH, which regulates human calcium levels essential for strong and healthy bones.

SAN ANTONIO -- Treatment with the chemotherapy agent capecitabine increased disease-free survival for women with HER2-negative breast cancer that was not eliminated by presurgery chemotherapy, according to results from the phase III CREATE-X clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

SAN ANTONIO -- Premenopausal women whose invasive breast cancers were of the luminal A subtype had comparable 10-year disease-free survival rates regardless of whether or not they received adjuvant chemotherapy, according to data from the phase III DBCG77B clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

SAN ANTONIO -- Adding denosumab to adjuvant aromatase inhibitor therapy improved disease-free survival for postmenopausal patients with early-stage, hormone receptor (HR)-positive breast cancer, according to results from the phase III ABCSG-18 clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

SAN ANTONIO -- Patients with stage 2 or stage 3 triple-negative breast cancer (TNBC) who had a pathologic complete response (pCR) after presurgery chemotherapy had increased event-free and overall survival compared with those who had more than minimal residual invasive disease at surgery following presurgery chemotherapy, according to results from the randomized phase II CALGB/Alliance 40603 clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

SALT LAKE CITY, Utah, Dec. 9, 2015 - Myriad Genetics, Inc. (NASDAQ: MYGN), a leader in molecular diagnostics and personalized medicine, today announced it will highlight three scientific presentations related to its myRisk Hereditary Cancer test at the 2015 San Antonio Breast Cancer Symposium (SABCS) in San Antonio, Texas. Data include results from studies that advance the understanding of hereditary cancer testing using multi-gene panels to evaluate patients at risk for or diagnosed with breast cancer.

Barcelona, 9 December 2015. An eye-opening article from the International Cancer Genome Consortium (ICGC) was published today in the prestigious journal Nature Communications. It lays a foundation for the coming era of research in cancer genomics. The project, led by the Centro Nacional de Analisis Genómico (CNAG-CRG) and the German Cancer Research Center (DKFZ) is the result of an effort to create reliable standards to obtain accurate results in the detection of somatic mutations, which are a hallmark of cancer genomes.

Biologists at UC San Diego have found that a method they developed to identify and characterize new antibiotics can be employed to screen natural products quickly for compounds capable of controlling antibiotic resistant bacteria.

CLEVELAND, Ohio (December 9, 2015)--After menopause, more than half of women may have vulvovaginal symptoms that have a big impact on their lifestyle, emotions, and sex life. What's more, the symptoms tend to travel with other pelvic troubles, such as prolapse and urinary and bowel problems. But many women aren't getting help, shows a study published online today in Menopause, the journal of The North American Menopause Society (NAMS).

Mothers who smoke are putting more than their own health at risk, suggests a study published today in BJOG: an International Journal of Obstetrics and Gynaecology (BJOG). Young men whose mothers smoked during pregnancy had lower aerobic fitness compared to those whose mothers did not.

The unseen responses of remote offshore lighthouse in the face of severe storms are revealed in a new study by Plymouth University.

A team from the School of Marine Science and Engineering considered historical and contemporary observations of the wave impact loading on rock lighthouses during storm conditions.

They combined these with data obtained in a pilot study on the Eddystone Lighthouse during the winter of 2013/14, and found the motion of the tower was smaller than might have been suggested by anecdotal observations.

The cheetah (Acinonyx jubatus) is now at home on the African plains, but it started a migration 100, 000 years ago from North America towards its current habitat. The research, published in the open access journal Genome Biology, found that the migration from North America was costly for the species, triggering the first major reduction in their gene pool.

The first international patient registry has been launched for primary ciliary dyskinesia (PCD) - a rare lung disease causing long-term and recurring respiratory infections, with no approved treatments and no cure.

Cancer Research UK scientists have found that five in six women with increased risk of breast cancer turn down drugs likely to prevent the disease, according to research published in Annals of Oncology.

Researchers at Queen Mary University of London collected data from 26 international studies totalling more than 21,000 women of all ages who were at increased risk of developing breast cancer. The women in these studies were offered a five-year course of preventive medication to lower their risk of developing breast cancer.