Body

Scientists create custom 3-dimensional structures with 'DNA origami'

BOSTON--By combining the art of origami with nanotechnology, Dana-Farber Cancer Institute researchers have folded sheets of DNA into multilayered objects with dimensions thousands of times smaller than the thickness of a human hair. These tiny structures could be forerunners of custom-made biomedical nanodevices such as "smart" delivery vehicles that would sneak drugs into patients' cells, where they would dump their cargo on a specific molecular target.

Understanding the therapeutic process of mother-infant psychotherapy

(Boston) – Psychotherapists who treat mothers suffering from postpartum depression and other mood disorders with their infants have developed a proven process that contributes to a greater positive experience with immediate insights for the mothers to develop healthy connections between their maternal experiences and their infants' behaviors.

Research team finds important role for junk DNA

Scientists have called it "junk DNA." They have long been perplexed by these extensive strands of genetic material that dominate the genome but seem to lack specific functions. Why would nature force the genome to carry so much excess baggage?

Big boost for global health called for in IOM report

WASHINGTON -- To fulfill America's humanitarian obligations as a member of the international community and to invest in the nation's long-term health, economic interests, and national security, the United States should reaffirm and increase its commitment to improving the health of developing nations, says a new report from the Institute of Medicine.

Vitamin D may halt lung function decline in asthma and COPD

ATS 2009, SAN DIEGO—Vitamin D may slow the progressive decline in the ability to breathe that can occur in people with asthma as a result of human airway smooth muscle (HASM) proliferation, according to researchers at the University of Pennsylvania.

Protein from algae shows promise for stopping SARS

ATS 2009, SAN DIEGO— A protein from algae may have what it takes to stop Severe Acute Respiratory Syndrome (SARS) infections, according to new research. A recent study has found that mice treated with the protein, Griffithsin (GRFT), had a 100 percent survival rate after exposure to the SARS coronavirus (SARS-CoV), as compared to a 30 percent survival for untreated mice.

The research will be presented at the American Thoracic Society's 105th International Conference in San Diego on Wednesday, May 20.

MS patients more compliant with medications when managed by specialty pharmacy

ORLANDO, Fla.—May 19, 2009—Multiple sclerosis patients managed by a specialty pharmacy program were more compliant with medication, and had a lower risk of being hospitalized for their disease than those who were not managed by a specialty pharmacy program, according to a study completed by HealthCore, Inc.

HealthCore researcher Jingbo Yu presented the study today at the International Society of Pharmacoeconomic and Outcomes Research 14th Annual International Meeting in Orlando, Fla. The retrospective study analyzed medical and pharmacy claims data.

Novel approach estimates nanoparticles in environment

DURHAM, N.C. – Without knowing how much of an industrial chemical is being produced, it is almost impossible for scientists to determine if it poses any threat to the environment or human health.

Civil engineers at Duke University believe they have come up with a novel way of estimating how much of one such material – titanium dioxide – is being generated, laying the groundwork for future studies to assess any possible risks.

Bacteria with a built-in thermometer

Researchers in the "Molecular Infection Biology group" at the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Braunschweig Technical University could now demonstrate for the first time that bacteria of the Yersinia genus possess a unique protein thermometer – the protein RovA - which assists them in the infection process. RovA is a multi-functional sensor: it measures both the temperature of its host as well as the host's metabolic activity and nutrients.

Strong immune response to new siRNA drugs in development may cause toxic side effects

New Rochelle, NY, May 20, 2009—Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design siRNA drugs to avoid it are critical topics explored in a timely review article published online ahead of print in Oligonucleotides, a peer-reviewed journal published by Mary Ann Liebert, Inc.

ISU researcher identifies genetic pathway responsible for much of plant growth

AMES, Iowa -- Researchers at Iowa State University have discovered a previously unknown pathway in plant cells that regulates plant growth.

Yanhai Yin, an assistant professor in genetics, development and cell biology, examined signaling mechanisms of a plant hormone called brassinosteroids. The hormone controls the growth of cells.

The brassinosteroids (BRs) have a major impact on how large the plant grows, says Yin.

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

AUGUSTA, Ga. – A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say.

Levels of the protein, βarrestin2, are lower in some prostate cancer cells than in normal prostate cells while expression of testosterone-fed androgen receptors is higher, they report in Proceedings of the National Academy of Sciences Online Early Edition this week.

Stanford scientists find heat-tolerant coral reefs that may resist climate change

Experts say that more than half of the world's coral reefs could disappear in the next 50 years, in large part because of higher ocean temperatures caused by climate change. But now Stanford University scientists have found evidence that some coral reefs are adapting and may actually survive global warming.

Old stain in a new combination

New combinations of agents based on the oldest synthetic malaria drug, the methylene blue stain, can curb the spread of malaria parasites and make a significant contribution to the long-term eradication called for by the international "Roll Back Malaria Initiative." In a study on 160 children with malaria in Burkina Faso, specialists in tropical medicine from the Heidelberg University Hospital have shown that in combination with newer malaria drugs, methylene blue prevents the malaria pathogen in infected persons from being re-ingested by mosquitoes and then transmitted to others and is thu

Action of ghrelin hormone increases appetite and favors accumulation of abdominal fat

The ghrelin hormone not only stimulates the brain giving rise to an increase in appetite, but also favours the accumulation of lipids in visceral fatty tissue, located in the abdominal zone and considered to be the most harmful. This is the conclusion of research undertaken at Metabolic Research Laboratory of the University Hospital of Navarra, published recently in the International Journal of Obesity.