Body

Our health depends in large part upon the ability of specialized enzymes to find and repair the constant barrage of DNA damage brought on by ultraviolet light radiation and other sources. In a new study NYU School of Medicine researchers reveal how an enzyme called RNA polymerase patrols the genome for DNA damage and helps recruit partners to repair it. The result: fewer mutations and consequently less cancer and other kinds of disease.

This news release is available in German.

Competition may have a high cost for at least one species of tropical seaweed.

Researchers examining the chemical warfare taking place on Fijian coral reefs have found that one species of seaweed increases its production of noxious anti-coral compounds when placed into contact with reef-building corals. But as it competes chemically with the corals, the seaweed grows more slowly and becomes more attractive to herbivorous fish, which boost their consumption of the skirmishing seaweed by 80 percent.

Increasingly, biologists have come to realize that RNA is not merely a transitional state between DNA and proteins but plays a major role in determining whether and how genes are turned into a protein product. Gaining a deeper understanding of RNA regulation can help scientists shed light on diseases that arise when this function goes awry.

Producing brightly speckled red and green snapshots of many different tissues, Johns Hopkins researchers have color-coded cells in female mice to display which of their two X chromosomes has been made inactive, or "silenced."

Scientists have long known that the silencing of one X chromosome in females — who have two X chromosomes in every cell — is a normal occurrence whose consequences can be significant, especially if one X chromosome carries a normal copy of a gene and the other X chromosome carries a mutated copy.

COLUMBUS, Ohio – Currently, doctors use chromosome markers and gene mutations to determine the best treatment for patients with acute myeloid leukemia (AML). But a new study suggests that a score based on seven mutated genes and the epigenetic changes that the researchers discovered were also present might help guide treatment by identifying novel subsets of patients.

Philadelphia, Pa. (January 7, 2013) – As perceived by both patients and doctors, the cosmetic results after "lumpectomy" for breast cancer differ for African-American versus Caucasian women, suggests a pilot study in the Plastic and Reconstructive Surgery—Global Open®, the official open-access medical journal of the American Society of Plastic Surgeons (ASPS).

TORONTO, January 8, 2014 – The number of centenarians in Ontario increased by more than 70 per cent over the last 15 years with women making up more than 85 per cent of people 100 or older, according to new research by the Institute for Clinical Evaluative Sciences (ICES) and Women's College Hospital.

The findings, published today in the Journal of the American Geriatrics Society, are among the first to examine centenarians in a large geographic population and the healthcare services they receive.

Researchers at Case Western Reserve University have identified a microRNA biomarker that shows promise in predicting treatment response in the most common form of ovarian cancer – a breakthrough that has the potential to improve outcomes for patients with the disease.

New research has shown that negative feedback loops in cell signalling systems can be essential for a cell's ability to perceive the strength of a growth stimulus. Cells lacking the feedback loop became insensitive to the level of the stimulus in a manner similar to a cancerous cell displaying unrestrained growth.

New Rochelle, NY, January 7, 2014—African American men have an increased risk of prostate cancer and are two times more likely than Caucasian American men to die from the disease. Despite recent questions about the overall usefulness of prostate-specific antigen (PSA) testing to detect prostate cancer, should PSA screening be used to detect early-stage disease to help save lives in this at-risk population? The controversy is explored in a Review article in Journal of Men's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.

FALLS CHURCH, Va. (January 8, 2014) — Older firefighters who are chronically exposed to heat stress on the job could be more heat resilient over time. A recent study published in the December issue of the Journal of Occupational and Environmental Hygiene (JOEH) found that older firefighters may be able to tolerate more challenging or arduous work environments before they feel affected by the heat, compared to non-heat-exposed workers who would need to stop work prematurely.

New Rochelle, NY, January 7, 2014—Packaging replacement genes in viruses is an effective method to deliver them to target tissues, but the human body mounts an immune response against the virus.

'Location, location, location' is an adage also true for the European grapevine moth, it seems. Research led by Fanny Vogelweith of the Université de Bourgogne and INRA Bordeaux-Aquitaine in France has shown that these pests are better adapted and more successful in certain French wine-growing regions than in others, because of the variety of grape on which they occur and the abundance of their natural enemies around them. The findings were published in Springer's journal Naturwissenschaften – The Science of Nature.

A dollar bill gets around, passing from hand to hand, falling on streets and sidewalks, eventually getting so grimy that a bank machine flags it and sends it to the shredder. Rather than destroying it, scientists have developed a new way to clean paper money to prolong its life. The research, which appears in the ACS journal Industrial & Engineering Chemistry Research, could save billions and minimize the environmental impact of banknote disposal.