Body

A team that includes Dartmouth College researchers has discovered a new way to detect cardiolipin, a key indicator of heart diseases and some genetic disorders.

The results, which appear in the journal Analytical Chemistry, may eventually help to diagnose these conditions earlier on and to provide real-time monitoring of cardiolipin levels.

Lincoln, Neb., Jan. 16, 2014 -- Using a camera-equipped robot to explore beneath the Ross Ice Shelf off Antarctica, scientists and engineers with the Antarctic Geological Drilling (ANDRILL) Program made an astonishing discovery.

Thousands upon thousands of small sea anemones were burrowed into the underside of the ice shelf, their tentacles protruding into frigid water like flowers on a ceiling.

Scientists at the Buck Institute for Research on Aging have promoted health and increased lifespan in Drosophila by altering the symbiotic, or commensal, relationship between bacteria and the absorptive cells lining the intestine. The research, appearing in the January 16, 2014 edition of Cell, provides a model for studying many of the dysfunctions that are characteristic of the aging gut and gives credence to the growing supposition that having the right balance of gut bacteria may be key to enjoying a long healthy life.

Those free-swimming jellyfish in the sea don't start out in that familiar medusa form, but rather start as sessile and asexual polyps. Now, researchers reporting in the Cell Press journal Current Biology on January 16 have discovered what triggers that transformation in the moon jellyfish (Aurelia aurita). The key is a novel metamorphosis hormone that accumulates during the cold winter to induce a synchronized emergence of jellyfish in the spring.

Monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer. Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal.

In this issue of the Journal of Clinical Investigation, Marjolein van Egmond and colleagues at the VU University Medical Center found that macrophage populations mediate tumor cell removal following monoclonal antibody treatment by actively phagocytosing tumor cells.

Monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer. Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal.

One of the factors underlying the development of type 2 diabetes is loss of β cell mass, resulting in decreased insulin production. Once lost, β cell mass cannot be restored. In contrast, infants with focal hyperinsulinism of infancy exhibit rapid expansion of the β cell mass due to a silencing of a region of chromosome 11 that includes the gene encoding the cell cycle inhibitor p57Kip2.

PHILADELPHIA - At the heart of brain diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease is protein misfolding, in which distorted proteins are unable to perform their normal functions. At present, there is no known way to reverse protein misfolding.

LA JOLLA, CA—January 16, 2014—Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new drug discovery technique, which allows them to find—relatively quickly and cheaply—antibodies that have a desired effect on cells. The TSRI scientists used the technique to discover two antibodies that protect human cells from a cold virus.

BOSTON - A group of international researchers, led by a research fellow in the Harvard Medical School-affiliated Institute for Aging Research at Hebrew SeniorLife, published a paper today in Cell describing a study aimed at better understanding how inherited genetic differences, or variants, predispose certain individuals to develop diseases such as type 2 diabetes. The study integrated computational methodology with experimentation to address and prove underlying genetic causes of type 2 diabetes.

The immune system plays an important role in the heart's response to injury. But until recently, confusing data made it difficult to distinguish the immune factors that encourage the heart to heal following a heart attack, for example, from those that lead to further damage.

How does Streptococcus pyogenes, or Group A streptococcus (GAS) — a bacterial pathogen that can colonize humans without causing symptoms or can lead to mild infections — also cause life-threatening diseases such as necrotizing fasciitis (commonly known as flesh-eating disease) and streptococcal toxic shock syndrome?

The human body is daily exposed to external assaults such as bacteria, ultraviolet light or chemical agents. Skin, the largest organ of the body, is the first line of defense against these agents. Skin performs this function thanks to the close connections established between its cells (e.g. adherens junctions). The loss of cell adhesion between these cells is related to inflammatory diseases and cancer, hence the special interest in this area of research over the past years.

Lincoln, Neb., Jan. 16, 2014 -- Ask most workers if they've ever had a narcissist for a boss and you'll hear stories of leaders who have taken credit for others' work, made decisions without consulting others and used every opportunity to talk about themselves.

Yet, there have been scholars who have argued that the confidence that comes with narcissism is essential for leader success. Research has yielded mixed findings -- some studies have shown narcissism relates to poorer organizational outcomes while others find that narcissistic leaders are more effective.

MANHATTAN, Kan. -- The novel avian H7N9 influenza virus has caused more than 130 human infections with 43 deaths in China. New research, conducted under the supervision of Kansas State University's Juergen Richt, is showing promise in helping to fight this deadly virus.

"Emergence of a novel drug-resistant H7N9 influenza virus: Evidence-based clinical potential of a natural IFN-alpha for infection control and treatment" is set to publish in an early online edition of January's Expert Review of Anti-infective Therapy journal.