Body

Tobacco smoking and high blood pressure are biggest killers of Japanese adults

The life expectancy of a person born in Japan is among the highest in the world (82.9 years) yet tobacco smoking and high blood pressure are still the major risk factors for death among adults in Japan, emphasizing the need to reduce tobacco smoking and to improve ongoing programs designed to help people manage multiple cardiovascular risk factors, including high blood pressure, according to a study published in this week's PLoS Medicine.

Availability and use of sanitation reduces by half the likelihood of parasitic worm infections

Adding the acid reflux drug lansoprazole to a standard inhaled steroid treatment for asthma does not improve asthma control in children who have no symptom of acid reflux, according to a new study funded in part by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. Lansoprazole therapy slightly increased the risk of sore throats and other respiratory problems in children, however.

BOSTON, MA -- Lifestyle counseling, practiced as part of routine care for people with diabetes, helps people more quickly lower blood glucose, blood pressure and cholesterol levels and keep them under control, according to a large, long-term study published in the February issue of Diabetes Care.

CHICAGO – Children without symptoms of gastroesophageal reflux whose asthma was being poorly controlled with anti-inflammatory treatment did not have an improvement in symptoms or lung function with the added treatment of the proton pump inhibitor lansoprazole, compared to patients who received placebo, according to a study in the January 25 issue of JAMA. Use of lansoprazole was associated with increased adverse events.

CHICAGO – Among women with invasive epithelial ovarian cancer, patients having a germline (gene change in a reproductive cell that could be passed to offspring) mutation in the BRCA1 or BRCA2 genes was associated with improved 5-year overall survival, with BRCA2 carriers having the best prognosis, according to a study in the January 25 issue of JAMA.

CHICAGO – Elevated exposures in children to perfluorinated compounds, which are widely used in manufacturing and food packaging, were associated with lower antibody responses to routine childhood immunizations, according to a study in the January 25 issue of JAMA.

Boston, MA—A new study finds that perfluorinated compounds (PFCs), widely used in manufactured products such as non-stick cookware, waterproof clothing, and fast-food packaging, were associated with lowered immune response to vaccinations in children. It is the first study to document how PFCs, which can be transferred to children prenatally (via the mother) and postnatally from exposure in the environment, can adversely affect vaccine response.

The study appears in the January 25, 2012 issue of the Journal of the American Medical Association (JAMA).

Asthma and gastroesophageal reflux (GER) are both common illnesses in children. GER in children often occurs without the typical symptoms of heartburn, and physicians frequently prescribe the acid reflux drug lansoprazole to supplement the standard inhaled steroid treatment for children with uncontrolled asthma regardless of GER symptoms.

When it comes to conserving the world's orchids, not all forests are equal. In a paper to be published Jan. 25 in the journal Molecular Ecology, Smithsonian ecologists revealed that an orchid's fate hinges on two factors: a forest's age and its fungi.

Roughly 10 percent of all plant species are orchids, making them the largest plant family on Earth. But habitat loss has rendered many threatened or endangered. This is partly due to their intimate relationship with the soil.

The fate of the world's great whale species commands global attention as a result of heated debate between pro and anti-whaling advocates, but the fate of smaller marine mammals is less understood, specifically because the deliberate and accidental catching and killing of dolphins, porpoises, manatees, and other warm-blooded aquatic species are rarely studied or monitored.

Santa Barbara, CA –The Bren School-based authors of a study published Jan. 20 in the journal PLoS ONE have observed toxicity to marine organisms resulting from exposure to a nanoparticle that had not previously been shown to be toxic under similar conditions.

A molecule embedded in the membrane of human liver cells that aids in cholesterol absorption also allows the entry of hepatitis C virus, the first step in hepatitis C infection, according to research at the University of Illinois at Chicago College of Medicine.

The cholesterol receptor offers a promising new target for anti-viral therapy, for which an approved drug may already exist, say the researchers, whose findings were reported online in advance of publication in Nature Medicine.

Research involving scientists at The University of Nottingham has taken us a step closer to breeding hardier crops that can better adapt to different environmental conditions and fight off attack from parasites.

In a paper published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), the researchers have shown that they can alter root growth in the plant Arabidopsis thaliana, or thale cress, by controlling an important regulatory protein.

New Rochelle, NY, January 24, 2012—The time for commercial development of gene therapy has come. Patients with diseases treatable and curable with gene therapy deserve access to the technology, which has demonstrated both its effectiveness and feasibility, says James Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy in a provocative commentary and accompanying videocast.