Body

Ancient African cattle first domesticated in Middle East

Geneticists and anthropologists previously suspected that ancient Africans domesticated cattle native to the African continent nearly 10,000 years ago. Now, a team of University of Missouri researchers has completed the genetic history of 134 cattle breeds from around the world. In the process of completing this history, they found that ancient domesticated African cattle originated in the "Fertile Crescent," a region that covered modern day Iraq, Jordan, Syria and Israel.

Autoimmune drug may help prevent kidney disease caused by diabetes

Washington, DC (March 27, 2014) — A drug currently used to treat autoimmune disease may also help prevent the kidney-damaging effects of diabetes, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that clinical trials should be designed to test the drug in diabetic patients.

US clean-air efforts stay on target

HOUSTON – (March 27, 2014) – National efforts in the last decade to clear the air of dangerous particulate matter have been so successful that most urban areas have already attained the next benchmark, according to new research by Rice University.

Atmospheric researchers at Rice studied the state implementation plans (SIPs) from 23 regions mandated by the Environmental Protection Agency to reduce particulate matter (PM) smaller than 2.5 microns (PM 2.5) to less than 15 micrograms per cubic meter by 2009.

Mechanical forces driving breast cancer lead to key molecular discovery

The stiffening of breast tissue in breast-cancer development points to a new way to distinguish a type of breast cancer with a poor prognosis from a related, but often less deadly type, UC San Francisco researchers have found in a new study.

The findings, published online March 16, 2014 in Nature Medicine, may lead eventually to new treatment focused not only on molecular targets within cancerous cells, but also on mechanical properties of surrounding tissue, the researchers said.

Consistent blood pressure control may cut rate of second stroke in half

Stroke survivors who consistently control their blood pressure may reduce the likelihood of a second stroke by more than half, according to new research in the American Heart Association journal Stroke.

Notre Dame scientists develop largest developmental proteomic data set for any animal

Now that the human genome is sequenced, University of Notre Dame researchers are focusing on the study of the proteome, which is the protein content of an organism, tissue or cell. Bioanalytical chemist Norman Dovichi and molecular biologist Paul Huber have successfully tracked the changing patterns of protein expression during early development of Xenopus laevis, or African clawed frog, embryos. They have developed the largest data set on developmental proteomics for any organism, and have included the single-cell zygote.

Natural history dying of neglect

Natural history provides essential knowledge for human wellbeing, yet its research, use and instruction in academia, government agencies and non-government organizations is declining drastically.

Simon Fraser University ecologist Anne Salomon is among 17 authors of a new paper that claims this decline in the developed world could seriously undermine the world's progress in research, conservation and management.

The circadian clock is like an orchestra with many conductors

ANN ARBOR—You've switched to the night shift and your weight skyrockets, or you wake at 7 a.m. on weekdays but sleep until noon on weekends—a social jet lag that can fog your Saturday and Sunday.

Life runs on rhythms driven by circadian clocks, and disruption of these cycles is associated with serious physical and emotional problems, says Orie Shafer, a University of Michigan assistant professor of molecular, cellular and developmental biology.

Scientists synthesize first functional 'designer' chromosome in yeast

An international team of scientists led by Jef Boeke, PhD, director of NYU Langone Medical Center's Institute for Systems Genetics, has synthesized the first functional chromosome in yeast, an important step in the emerging field of synthetic biology, designing microorganisms to produce novel medicines, raw materials for food, and biofuels.

Study shows promise of preserving fertility in boys with cancer

WINSTON-SALEM, N.C. – March 27, 2014 – Scientists have moved a step closer to being able to preserve fertility in young boys who undergo chemotherapy and radiation treatments for cancer. The new research, published in Fertility and Sterility, the journal of the American Society for Reproductive Medicine, addresses the safety of an option scientists are developing for boys who aren't sexually mature and cannot bank sperm.

Research from CHORI scientists demonstrates first genome methylation in fruit fly

March 27, 2013, Oakland, CA – A group of scientists from Children's Hospital Oakland Research Institute and UC Berkeley report the first mapping of genome methylation in the fruit-fly Drosophila melanogaster in their paper "Genome methylation in D. melanogaster is found at specific short motifs and is independent of DNMT2 activity," published this month in Genome Research.

Antidepressants during pregnancy linked to preterm birth

BOSTON -- Antidepressant medications taken by pregnant women are associated with increased rates of preterm birth. This finding reinforces the notion that antidepressants should not be used by pregnant women in the absence of a clear need that cannot be met through alternative approaches, say researchers from Brigham and Women's Hospital, Vanderbilt University, MetroWest Medical Center, and Tufts Medical Center.

Adult cancer drugs show promise against an aggressive childhood brain tumor

(MEMPHIS, Tenn. – March 27, 2014) The quest to improve survival of children with a high-risk brain tumor has led St. Jude Children's Research Hospital investigators to two drugs already used to treat adults with breast, pancreatic, lung and other cancers. The study was published today online ahead of print in the journal Cancer Cell.

Cancer researchers find key protein link

HOUSTON – (March 27, 2014) – A new understanding of proteins at the nexus of a cell's decision to survive or die has implications for researchers who study cancer and age-related diseases, according to biophysicists at the Rice University-based Center for Theoretical Biological Physics (CTBP).

Experiments and computer analysis of two key proteins revealed a previously unknown binding interface that could be addressed by medication. Results of the research appear this week in an open-source paper in the Proceedings of the National Academy of Sciences.

Congress budget pact good for global health but NIH cuts threaten US innovations

Washington, DC (March 27, 2014)—While a ceasefire in Washington's budget wars has restored funding for a range of programs targeting global health threats like AIDS and tuberculosis (TB), the simultaneous underfunding of the world's biggest sponsor of global health research and development (R&D) puts future progress at risk, warns a new report from a coalition of nonprofit groups focused on advancing innovation to save lives. The Global Health Technologies Coalition (GHTC) released their annual policy report today at a Capitol Hill briefing.