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Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia.

Results of the research by Johns Hopkins Kimmel Cancer Center investigators, described March 6 in the journal Blood, show that two doses a day of TTT-3002 eliminated leukemia cells in a group of mice within 10 days. The treatment performed as well as or better than similar drugs in head-to-head comparisons.

MAYWOOD, Ill. – People who are injured while binge drinking are much slower to heal from wounds suffered in car accidents, shootings, fires, etc.

Now a new study is providing insights into why alcohol has such a negative effect on wound healing. Loyola University Chicago Stritch School of Medicine researchers report that binge alcohol exposure significantly reduced levels of key components of the immune system involved in healing.

The structure of a key part of the machinery that allows cells to divide has been identified by researchers at the University of California, Davis -- opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.

"The structure of kinesin-5 is unexpected, and the implications are big -- it allows us to target it, for example in various forms of cancer," said Jawdat Al-Bassam, assistant professor of molecular and cellular biology at UC Davis, who led the project.

Washington, D.C.—Global health funding hit an all-time high of $31.3 billion in 2013, five times greater than in 1990. Yet with 3.9% growth from 2012 to 2013, the year-over-year increase falls short of the rapid rates seen over the previous decade, according to new research by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington being published online in a web first edition on April 8 by Health Affairs.

April 8, 2014 CHAPEL HILL, N.C. – Researchers at UNC School of Medicine have pinpointed a viral protein that plays a major role in making respiratory syncytial virus (RSV) the most common cause of hospitalization in children under one year of age.

PHILADELPHIA (April 8, 2014) – The cartoon character Homer J. Simpson once said "Alcohol: The source of, and solution to, all of life's problems."

The sage of the ubiquitous and fictional town of Springfield may have hit the nail on the head when it comes to human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) counseling and prevention. The more you drink and/or the more sex partners you have, the less likely you are to engage in HIV-prevention programs.

Work at the University of Colorado Cancer Center led to phase II trial of efatutazone with erlotinib in patients with refractory non-small cell lung cancer. Results are reported today at the American Association for Cancer Research (AACR) Annual Meeting 2014. While efatutazone did not improve the efficacy of erlotinib in this trial, researchers hope lessons from the trial will allow them to make better future use of the drug or other drugs in its class.

Glucosamine has been freely available in drugstores for many decades. It is widely used to treat arthritis and to prevent joint degeneration. Moreover, glucosamine is known to delay cancer growth. In addition, glucosamine reduces metabolism of nutritive sugars, as was already shown some 50 years ago.

HOUSTON – (April 8, 2014) – Creativity and innovation are not sufficiently integrated in either the business world or academic research, according to a new study by Rice University, the University of Edinburgh and Brunel University.

The findings are the result of the authors' review of the rapidly growing body of research into creativity and innovation in the workplace, with particular attention to the period from 2002 to 2013.

Scientists know that tapping into local expertise is key to conservation efforts aimed at protecting biodiversity – but researchers rarely give credit to these local experts. Now some scientists are saying that's a problem, both for the local experts and for the science itself.

To address the problem, a group of scientists is calling for conservation researchers to do a better job of publicly acknowledging the role of local experts and other non-scientists in conservation biology.

DALLAS – April 8, 2014 – UT Southwestern Medical Center researchers have demonstrated in both cancer cell lines and in mice that blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas.

This news release is available in German.

Facing the prospect of racial minority groups becoming the overall majority in the United States leads White Americans to lean more toward the conservative end of the political spectrum, according to research published in Psychological Science, a journal of the Association for Psychological Science.

The findings suggest that increased diversity in the United States could actually lead to a wider partisan divide, with more White Americans expressing support for conservative policies.

Synthetic genetic circuitry created by researchers at Rice University is helping them see, for the first time, how to regulate cell mechanisms that degrade the misfolded proteins implicated in Parkinson's, Huntington's and other diseases.

The Rice lab of chemical and biomolecular engineer Laura Segatori has designed a sophisticated circuit that signals increases in the degradation of proteins by the cell's ubiquitin proteasome system (UPS).

The research appears online today in Nature Communications.

Research from the University of Southampton has shown a drug, used in combination with chemotherapy to treat advanced colorectal cancer, is not effective in some settings, and indeed may result in more rapid cancer progression.