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Dartmouth Institute for Quantitative Biomedical Sciences (iQBS) researchers developed a new gene expression analysis approach for identifying cancer genes. The paper entitled, "How to get the most from microarray data: advice from reverse genomics," was published online March 21, 2014 in BMC Genomics. The study results challenge the current paradigm of microarray data analysis and suggest that the new method may improve identification of cancer-associated genes.

New research by scientists at the University of York sheds light on how bacteria exploit human proteins during infections.

A research team led by Professor Jennifer Potts, a British Heart Foundation Senior Research Fellow in York's Department of Biology, studied how Staphylococcus aureus, which can cause life-threatening human infections, attach to two proteins fibronectin and fibrinogen found in human blood.

Element 117, first discovered by Lawrence Livermore scientists and international collaborators in 2002, is one step closer to being named.

The existence of element 117 and its decay chain to elements 115 and 113 have been confirmed by a second international team led by scientists at GSI Helmholtz Centre for Heavy Ion Research, an accelerator laboratory located in Darmstadt, Germany. The research will appear in an upcoming issue of the journal, Physical Review Letters.

Partners of patients diagnosed with human papilloma virus (HPV)-positive oropharyngeal cancer (OPC) were no more likely to test positive for oral HPV infection than people in the general population, according to a study published in the April 28 online edition of the Journal of Clinical Oncology. The findings should lessen anxiety that OPC cancer is contagious, at least among long-term partners, and confirms that couples who have been together for several years do not need to change their intimacy or sexual behavior because of the cancer diagnosis.

The drug sofosbuvir has been available since January 2014 as a treatment for chronic hepatitis C infection. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) has now examined whether the new drug offers added benefit in comparison with the appropriate comparator therapy.

OAKLAND, Calif., May 2, 2014 — Women with high levels of a common liver enzyme measured prior to pregnancy were twice as likely to subsequently develop gestational diabetes than those with the lowest levels, according to a Kaiser Permanente study published today in the journal Diabetes Care.

The so-called Middle East respiratory syndrome (MERS) coronavirus was first found in June 2012 in a patient from Saudi Arabia, who suffered from severe pneumonia. Since this time more than 300 persons have developed an infection, of whom about a third died. The fact that the Arabian camel is the origin of the infectious disease has been confirmed recently. The transmission pathways of the viruses, however, have not been clear until now.

Viruses in humans and camels from one region are identical

SEATTLE — The United States is among just eight countries in the world to experience an increase in maternal mortality since 2003 – joining Afghanistan and countries in Africa and Central America, according to a new study by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington.

SEATTLE — Since the start of an international effort to address maternal and child mortality, millions of lives have been saved globally, two new studies by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington show.

Sendai, Japan -- Three-dimentional (3D) nanoporous graphene with preserved 2D Dirac electronic characters was successfully synthesized by Dr. Yoshikazu Ito and Prof. Mingwei CHEN at Advanced Institute for Materials Research (AIMR), Tohoku University. The nanoporous graphene is constructed by a single layer graphene sheet that is continuously inter-connected to form a complex 3D network structure. This free-standing nanoporous graphene with an excellent crystallinity possesses high mobility, holding great promise for the applications in electronic devices.

The research groups of Janne Ihalainen (University of Jyväskylä) and Sebastian Westenhoff (University of Gothenburg) have clarified how the atom structure of bacterial red light photosensors changes when sensing light. The research reveals structural changes in phytochrome protein when illuminated.

In a new study published today in Cell Reports, scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed to cancer. CTCF is a very well-studied DNA binding protein that exerts a major influence on the architecture of the human genome, but had not been previously linked to cancer. Over 30 years ago, frequent loss of one copy of chromosome 16 was first reported in breast cancer but the gene or genes responsible remained to be identified. Dr.

New pharmaceuticals to fight autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis and psoriasis, may be identified more effectively by adding genome analysis to standard drug screening, according to a new study by a research team led by UC San Francisco and Harvard researchers, in collaboration with Tempero and GlaxoSmithKlein.

Researchers have identified a section of the anthrax toxin Lethal Factor that could help produce a more effective vaccine.

Anthrax is a potentially lethal disease caused by a bacterium called Bacillus anthracis. The bacteria produce spores that when inhaled, ingested or absorbed into the skin release toxins. When anthrax affects the lungs or intestines it can cause death within a few days whilst infection of the skin (cutaneous anthrax) is less dangerous.

Scientists at USC have definitively demonstrated that large sets of variations in the genetic code that do not individually appear to have much effect can collectively produce significant changes in an organism's physical characteristics.

Studying the budding yeast Saccharomyces cerevisiae, USC's Matthew B. Taylor and Ian M. Ehrenreich found that the effects of these genetic variants can depend on four or more other variants in an individual's genome.