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A school-based scheme to encourage children to eat healthily and be active has had little effect, conclude researchers in a study published on bmj.com today.

The findings have relevance for researchers, policy makers, public health practitioners, and doctors, and they suggest that more intense interventions may be required.

Concerns about guardianship and privacy can discourage clinics from testing children for HIV, according to new research from Zimbabwe published this week in PLOS Medicine. The results of the study, by Rashida A. Ferrand of the London School of Hygiene & Tropical Medicine and colleagues, provide much-needed information on how to improve care of this vulnerable population.

In a PLOS Medicine guest editorial, Paul Glasziou, Professor of Evidence-Based Medicine at Bond University in Australia, explores how open access publications could help moderate and reduce the vast waste of global medical research.

Disturbed patterns of blood flow induce lasting epigenetic changes to genes in the cells that line blood vessels, and those changes contribute to atherosclerosis, researchers have found. The findings suggest why the protective effects of good blood flow patterns, which aerobic exercise promotes, can persist over time. An epigenetic change to DNA is a chemical modification that alters whether nearby genes are likely to be turned on or off, but not the letter-by-letter sequence itself.

The results are scheduled for publication in the Journal of Clinical Investigation.

Older people who undertake at least 25 minutes of moderate or vigorous exercise everyday need fewer prescriptions and are less likely to be admitted to hospital in an emergency, new research has revealed.

The findings, published in the journal PLOS ONE, reinforce the need for exercise programmes to help older people stay active. It could also reduce reliance on NHS services and potentially lead to cost savings.

A genetic variant linked to sudden cardiac death leads to protein overproduction in heart cells, Johns Hopkins scientists report. Unlike many known disease-linked variants, this one lies not in a gene but in so-called noncoding DNA, a growing focus of disease research. The discovery, reported in the June 5 issue of The American Journal of Human Genetics, also adds to scientific understanding of the causes of sudden cardiac death and of possible ways to prevent it, the researchers say.

The agency charged to protect patients from dangerous drug side effects needs to be far more vigilant when it comes to medications that affect blood pressure.

Robert P. Blankfield, MD, MS, a clinical professor of family medicine, issues this call to the U.S. Food and Drug Administration (FDA) in an editorial published recently in an online edition of the Journal of Cardiovascular Pharmacology and Therapeutics; the print version of the article is expected to appear this autumn.

Arterial hardening, also known as atherosclerosis, is the result of plaque buildup in the walls of arteries and over time can lead to cardiovascular complications, including heart attack, stroke, and peripheral vascular disease.

Atherosclerotic plaques typically develop in arterial regions with disrupted blood flow. While blood flow disturbances are known to alter endothelial gene expression and function, it is not clear how altered blood flow induces these changes in endothelial cells.

An analysis of more than 600 class I (procedure/treatment should be performed/administered) American College of Cardiology/American Heart Association guideline recommendations published or revised since 1998 finds that about 80 percent were retained at the time of the next guideline revision, and that recommendations not supported by multiple randomized studies were more likely to be downgraded, reversed, or omitted, according to a study in the May 28 issue of JAMA.

Science crowdsourcing was used to disprove a widely held theory that "supertasters" owe their special sensitivity to bitter tastes to an usually high density of taste buds on their tongue, according to a study published in the open-access journal Frontiers in Integrative Neuroscience.

Oncologists now have a new understanding of the toxicity levels of specific chemotherapy regimens used for women with early stage breast cancer, according to research from The University of Texas MD Anderson Cancer Center.

The retrospective study, published in the Journal of Clinical Oncology, used large population-based data to compare the risk of hospitalization for six common chemotherapy regimens. Reasons for hospitalization included infection, fever, anemia, dehydration, neutropenia (low white blood cell count), thrombocytopenia (low blood platelets) and delirium.

Women with blood in their urine (hematuria) were less than half as likely as men with the same issue to be referred to a urologist for further tests, according to a new Vanderbilt University study.

The findings may help explain why women with bladder cancer are often diagnosed at a later stage in the disease and have worse mortality than men.

Since it started more than 30 years ago, funding the graduate medical education (GME) system has not evolved even as there has been a revolution in GME. The United States contributes almost $10 billion a year from Medicare into funding the GME system. However this system fails to provide the workforce needed for the 21st century and lacks the necessary transparency and accountability.

MISSOULA – A new article by researchers from the University of Montana, the U.S. Geological Survey and Montana Fish, Wildlife & Parks asserts that climate warming is increasing the hybridization of trout – interbreeding between native and non-native species – in the interior western United States.

MEDFORD/SOMERVILLE, Mass. (May 27, 2014) -- Developmental biologists at Tufts University, using a tadpole model, have shown that bioelectrical signals from distant cells control the incidence of tumors arising from cancer-causing genes and that this process is impacted by levels of a common fatty acid produced by bacteria found in the tadpole and also in humans.