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New findings by scientists at the University of California, Santa Cruz, suggest that an evolutionary arms race between rival elements within the genomes of primates drove the evolution of complex regulatory networks that orchestrate the activity of genes in every cell of our bodies.

The first direct comparison of treating non-squamous lung cancer with either pemetrexed or docetaxel in addition to cisplatin has shown that the two combinations achieve similar progression-free survival, although docetaxel was associated with more frequent adverse events.

At the ESMO 2014 Congress in Madrid, Dr Young-Chul Kim from Chonnam National University Medical School, South Korea, reported the results of an open-label phase III trial that included 149 patients with non-squamous non-small cell lung cancer (NSCLC) conducted at 14 centres in South Korea.

Measuring the expression levels of an enzyme involved in DNA synthesis can help predict the response of lung cancers to certain treatments, a Korean study has shown at the ESMO 2014 Congress in Madrid.

In a randomized phase II study, researchers showed that patients whose lung cancers expressed low levels of an enzyme called thymidylate synthase experienced a greater benefit from treatment with the combination of pemetrexed and cisplatin than those whose tumours expressed high levels.

The introduction of biennial colorectal cancer screening in a region of France increased the rate of diagnosis of high risk pre-cancerous adenomas (sometimes called polyps) by 89%, researchers have reported at the ESMO 2014 Congress in Madrid.

Dr Vanessa Cottet from INSERM Unité 866 in Dijon, France, and colleagues studied the region of Côte-d'Or, where a registry has been collecting data on adenomas since 1976. They wanted to evaluate the rate of diagnosis of adenomas before and after the initiation of a screening program using fecal occult blood testing that began in 2003.

Treatment with the targeted therapy drug crizotinib effectively halts the growth of lung tumors driven by rearrangements of the ROS1 gene. In an article receiving Online First publication in the New England Journal of Medicine to coincide with a presentation at the European Society for Medical Oncology meeting, an international research team reports that crizotinib treatment led to significant tumor shrinkage in 36 of 50 study participants and suppressed tumor growth in another 9.

Children who are exposed to chemotherapy or radiotherapy while in the womb suffer no negative impacts on mental or cardiac development, international studies presented at the ESMO 2014 Congress in Madrid have shown.

A new drug, anamorelin, improves appetite and body mass in patients with advanced lung cancer who are suffering cancer anorexia and cachexia, according to phase III data presented at the ESMO 2014 Congress in Madrid, Spain.

"Anorexia and cachexia are among the most troubling and distressing symptoms of advanced cancer, for both patients and their families," says the study's principal investigator, Dr Jennifer Temel from the Department of Medicine, Massachusetts General Hospital, Boston, USA.

The author of new research into organ trafficking has called for a concerted international effort to confront the problem.

Dr Ana Manzano, of the School of Sociology and Social Policy at the University of Leeds, says a combination of factors means nobody knows definitively how many organs are being traded across the world.

She said: "Unless these issues are addressed and countries work together to take firm action against the traffickers, more people who have their organs trafficked will die.

A bright orange poison dart frog with a unique call was discovered in Donoso, Panama, and described by researchers from the Smithsonian Tropical Research Institute and the Universidad Autónoma de Chiriquí in Panama, and the Universidad de los Andes in Colombia. In the species description published this week in Zootaxa, it was named Andinobates geminisae for Geminis Vargas, "the beloved wife of [coauthor] Marcos Ponce, for her unconditional support of his studies of Panamanian herpetology."

DALLAS – Sept. 26, 2014 – Lung cancer clinical trials exclude a substantial proportion of patients due to a history of prior cancer, as shown in an analysis by cancer researchers at UT Southwestern Medical Center.

The strikingly rapid spread of the Tree Bumblebee in Britain could be occurring because the bees readily live alongside humans in towns and villages – according to research from the University of East Anglia.

A new study published today shows that Tree Bumblebees are associated with built-up areas and that these areas form a large part of their habitat use.

Policies put into place by major funding agencies like the National Institutes of Health (NIH), and to a lesser extent by scientific journals, appear to be meeting the goal of increasing the sharing of scientific resources among life science investigators. As reported in the open-access journal PLOS ONE, 65 percent of surveyed investigators at major U.S. research institutions believed that NIH policies instituted in recent years had markedly improved the sharing of scientific data.

Anti-odour clothing may not be living up to its promise, and an ALES researcher is saying itcould all be a matter of how the product was tested.

In two separate experiments, Human Ecology researcher Rachel McQueen and her team found that some antimicrobial textiles were far more effective at performing their advertised tasks in the lab than in testing on humans. In one experiment, the fabrics were designed to help lower the risk of infection; in the second, the fabric was treated with a silver compound, which can be marketed preventing odour in clothing.

September 26, 2014 – Decision analysis techniques can help surgeons and patients evaluate alternatives for breast reconstruction—leading to a "good decision" that reflects the woman's preferences and values, according to an article in the October issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

September 26, 2014 – A new standardized assessment provides a useful tool for tracking surgeons' progress as they develop the skills needed to perform robot-assisted microsurgery, reports a study in the October issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).