Body

Chasing EHEC with the computer

Venice to suffer fewer storm surges

Venice – the City of Dreams – may have one less nightmare to deal with following a finding that the frequency of extreme storm surge events generated by Adriatic Sea tempests could fall by about 30 per cent by 2100.

A team of international scientists led by CSIRO's Dr Alberto Troccoli studied atmospheric circulation in the Mediterranean region to assess climate impacts through changes in storm surge frequency in Venice – a World Heritage-listed city built on 117 small islands and considered vulnerable to high sea levels (locally known as Acqua Alta).

Gender differences in risk pathways for adolescent substance abuse and early adult alcoholism

Clinically ascertained reports suggest that boys and girls with attention deficit hyperactivity disorder (ADHD) may differ from each other in their vulnerability to substance use problems, say the researchers of the University of Helsinki and University of Jyväskylä, Finland.

Analysis finds mortality from all causes higher among hepatitis C-infected

[EMBARGOED FOR JUNE 10, 2011] Although liver-related mortality among those infected with hepatitis C is well-documented, little is known about deaths in these patients that are not related to liver problems. A new study published in Clinical Infectious Diseases and now available online (http://www.oxfordjournals.org/our_journals/cid/cir306.pdf) sought to determine mortality from all causes, including liver- and non-liver related deaths among hepatitis C patients in the general U.S. population.

Radiation after prostate removal is cost-effective, but less likely to be recommended by urologists

PHILADELPHIA—Receiving radiation therapy immediately after a radical prostatectomy is a cost-effective treatment for prostate cancer patients when compared with waiting and acting on elevated prostate-specific antigen (PSA) levels, according to a new study by researchers at Thomas Jefferson University and Hospital.

What's more, a separate, but related study, found that urologists were less likely than radiation oncologists to recommend adjuvant radiation therapy or to believe it improves overall survival.

Early agricultural piracy informs the domestication of rice

The origins of rice have been cast in a new light by research publishing in the open-access journal PLoS Genetics on June 9, 2011. By reconciling two theories, the authors show that the domestication of rice occurred at least twice independently but with extensive "borrowing" between the two subspecies.

Genome sequence could reveal 'Achilles' heels' of important wheat disease

Research published in PLoS Genetics today (9 June) provides insights into how an important fungal disease is able to evade wheat's defences. The researchers hope that the study, which reveals the fungus' complete genome sequence, will enable them to breed resistant crop plants or improve the use of pesticides.

Asteroid served up 'custom orders' of life's ingredients

Some asteroids may have been like "molecular factories" cranking out life's ingredients and shipping them to Earth via meteorite impacts, according to scientists who've made discoveries of molecules essential for life in material from certain kinds of asteroids and comets. Now it appears that at least one may have been less like a rigid assembly line and more like a flexible diner that doesn't mind making changes to the menu.

Fragile X protein acts as toggle switch in brain cells

New research shows how the protein missing in fragile X syndrome – the most common inherited form of intellectual disability – acts as a molecular toggle switch in brain cells.

The fragile X protein, called FMRP, hooks up with a group of molecules called microRNAs to switch the production of other proteins on and off in response to chemical signals, scientists at Emory University School of Medicine have discovered.

The results appear in the June 10 issue of Molecular Cell.

Deaths and major morbidity from asbestos-related diseases in Asia likely to surge in next 20 years

An alarming new article in Respirology issues a serious warning of massive rises in deaths from asbestos-related lung diseases in Asia. Dr Ken Takahashi, Acting Director of the WHO Collaborating Center for Occupational Health, and his team put together important data on asbestos use in 47 Asian countries in this landmark article. Cyprus, Israel and Japan had the highest age-adjusted mortality rates in Asia.

The downside -- and surprising upside - of microcredit

New Haven, Conn.—Microcredit, which involves giving small loans to very small businesses in an effort to promote entrepreneurship, has been widely touted as a way to reduce poverty and stimulate economic growth. A multitude of both non- and for-profit institutions are spending billions of dollars each year on microcredit ventures in developing nations around the globe.

Meteorite holds clues to organic chemistry of the early Earth

Washington, DC— Carbonaceous chondrites are a type of organic-rich meteorite that contain samples of the materials that took part in the creation of our planets nearly 4.6 billion years ago, including materials that were likely formed before our Solar System was created and may have been crucial to the formation of life on Earth. The complex suite of organic materials found in carbonaceous chondrites can vary substantially from meteorite to meteorite.

How killer immune cells avoid killing themselves

After eight years of work, researchers have unearthed what has been a well-kept secret of our immune system's success. The findings published online on June 9th in Immunity, a Cell Press publication, offer an explanation for how specialized immune cells are able to kill infected or cancerous cells without killing themselves in the process.

The focus of the study is a molecule known as perforin, whose job it is to open up a pore in cells targeted for destruction. With that pore in place, proteases known as granzymes can enter target cells and destroy them.

Biologists uncover regulatory mechanism for gene expression in the visual system

Biologists have uncovered a key regulatory mechanism used for gene expression in the visual system. Their findings, which appear in the latest issue of the journal Cell, offer new insights into the complexity behind the genetic make-up of biological systems.

New research describes key function of enzyme involved in RNA processing

CLEVELAND – June 9, 2011 – Researchers at the Case Western Reserve University School of Medicine have identified a cellular mechanism that is critical in maintaining normal cell function.