Body

DALLAS – Aug. 11, 2009 – People diagnosed with type 2 diabetes often resist taking insulin because they fear gaining weight, developing low blood sugar and seeing their quality of life decline.

A study recently completed at UT Southwestern Medical Center suggests that those fears are largely unfounded and that patients and physicians should consider insulin as a front-line defense, as opposed to a treatment of last resort for non-insulin-dependent diabetes.

Heart attacks and strokes — the leading causes of death in the United States and other developed countries — may have been rare for the vast majority of human history, suggests a study to be published in PLoS ONE on Tuesday, August 11.

"Understanding how physiological systems respond in [indigenous] populations helps us better understand conditions in countries like the United States at the beginning of the 20th century," said senior author Eileen Crimmins of the USC Davis School of Gerontology. "This also offers some insight into the worlds we evolved in."

Working with researchers in China, biologists at UC San Diego have discovered how a Chinese drug effective in killing parasitic roundworms works.

Their discovery of the drug's biological mechanism provides important new information about how to combat parasitic roundworms, which infect more than a billion people in tropical regions and are one of the leading causes of debilitation in underdeveloped countries. The researchers detail their findings in the current issue of the open-access journal PLoS Neglected Tropical Diseases.

The patient described in this paper, Amanda Mayer, age four, of Staten Island, N.Y., had previously undergone all three stages of the Fontan procedure at The Children's Hospital of Philadelphia, but developed severe complications. Her oxygen saturation was very low – only 72 percent, compared to normal levels of at least 95 percent – which indicated the possibility of abnormal connections between the veins and arteries in one of her lungs.

Edith Hessel and colleagues, at Dynavax Technologies Corporation, Berkeley, have identified the reason that humans and rodents respond differently to a molecule that is being developed to treat allergic diseases.

Muscular dystrophy, a group of inherited diseases characterized by progressive skeletal muscle weakness, can be caused by mutations in any one of a number of genes. Another gene can now be added to this list, as Yukiko Hayashi and colleagues, at the National Center of Neurology and Psychiatry, Japan, have now identified mutations in a gene not previously linked to muscular dystrophy as causative of a form of the disease in five nonconsanguineous Japanese patients.

Bone cells known as osteoblasts were recently shown to have a role in controlling the biochemical reactions that generate energy via secretion of the molecule osteocalcin. Gerard Karsenty and colleagues, at Columbia University College of Physicians and Surgeons, New York, therefore hypothesized that osteoblasts express a regulatory gene(s) that controls this osteoblast function and then identified Atf4 as this regulatory gene in mice.

When bees sting, they pump poison into their victims. Now the toxin in bee venom has been harnessed to kill tumor cells by researchers at Washington University School of Medicine in St. Louis. The researchers attached the major component of bee venom to nano-sized spheres that they call nanobees.

MADISON — In an advance that could help transform embryonic stem cells into a multipurpose medical tool, scientists at the University of Wisconsin-Madison have transformed these versatile cells into progenitors of white blood cells and into six types of mature white blood and immune cells.

August 10, 2009 - (BRONX, NY) - The deadliest part of the cancer process, metastasis, appears to rely on help from macrophages, potent immune system cells that usually defend vigorously against disease, researchers at Albert Einstein College of Medicine of Yeshiva University report.

University of British Columbia researchers have developed a new way to extract DNA and RNA from small or heavily contaminated samples that could help forensic investigators and molecular biologists get to "the truth."

"By exploiting the physical traits of DNA – electric charge, length and flexibility – we've been able to extract DNA from samples that would otherwise not produce enough clean DNA for analysis," says UBC Biophysics Prof. Andre Marziali.

TORONTO, ON – Excavations led by a University of Toronto archaeologist at the site of a recently discovered temple in southeastern Turkey have uncovered a cache of cuneiform tablets dating back to the Iron Age period between 1200 and 600 BCE. Found in the temple's cella, or 'holy of holies', the tablets are part of a possible archive that may provide insights into Assyrian imperial aspirations.

CHAPEL HILL – According to a new study, women with a family history of breast cancer were 59 percent less likely to develop breast cancer themselves if they breastfed their children.

"This is good news for women with a family history of breast cancer," says Alison Stuebe, assistant professor of obstetrics and gynecology at the University of North Carolina at Chapel Hill School of Medicine and lead author of the study, which is published in the Aug. 10 issue of Archives of Internal Medicine.

Four healthy lifestyle factors—never smoking, maintaining a healthy weight, exercising regularly and following a healthy diet—together appear to be associated with as much as an 80 percent reduction in the risk of developing the most common and deadly chronic diseases, according to a report in the August 10/24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Optimistic women have a lower risk of developing heart disease or dying from any cause compared to pessimistic women, according to research reported in Circulation: Journal of the American Heart Association.

Researchers also reported that women with a high degree of cynical hostility — harboring hostile thoughts toward others or having a general mistrust of people — were at higher risk of dying; however, their risk of developing heart disease was not altered.