A new analysis of an important trial of the blood pressure-lowering procedure, renal denervation, shows that the main results may have been affected by a number of confounding factors that partially explain the unexpected blood pressure responses in patients.
The analysis, published in the European Heart Journal [1], identified factors in the SYMPLICITY HTN-3 trial, such as variations in the way the procedure was performed and changes in patients' medications and drug adherence, which may have had a significant impact on the results.