Body

Montréal, February 8, 2010-– The research group of Dr. François Robert, a researcher at the Institut de recherches cliniques de Montréal (IRCM), in collaboration with the team of Dr. Daniel Durocher (Samuel Lunenfeld Research Institute and University of Toronto) accomplished a technical breakthrough: they mapped all the fragile sites of a living organism, the budding yeast Saccharomyces cerevisiae. The method used by the researchers can be applied to humans. This study has been published online today in the scientific journal Nature Structural and Molecular Biology.

Guelph, Ontario--Just because you don't swallow the worm at the bottom of a bottle of mescal doesn't mean you have avoided the essential worminess of the potent Mexican liquor, according to scientists from the Biodiversity Institute of Ontario (BIO) at the University of Guelph.

They have discovered that the liquid itself contains the DNA of the agave butterfly caterpillar – the famously tasty mescal "worm".

MINNEAPOLIS/ST.PAUL (February 8, 2010)-— Consuming two or more soft drinks per week increased the risk of developing pancreatic cancer by nearly two-fold compared with individuals who did not consume soft drinks, according to a report in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Although relatively rare, pancreatic cancer remains one of the most deadly; only 5 percent of people who are diagnosed survive five years later.

Cerebral palsy (CP) has increased in infants born prematurely in the US, according to data presented by researchers from Loyola University Health System (LUHS). These findings were reported at the 30th Annual Meeting of the Society for Maternal-Fetal Medicine in Chicago. They also were published in the latest issue of the American Journal of Obstetrics & Gynecology.

Scientists have identified a gene they say is a strong candidate for involvement in premenstrual dysphoric disorder (PMDD) and other maladies associated with the natural flux in hormones during the menstrual cycle. In a paper published Monday in the Proceedings of the National Academy of Sciences, Rockefeller University researchers detail experiments in mice showing that a common human variant of the gene increases anxiety, dampens curiosity and tweaks the effects of estrogen on the brain, impairing memory.

HOUSTON - Overexpression of low-molecular-weight (LMW-E) forms of the protein cyclin E renders the aromatase inhibitor letrozole ineffective among women with estrogen-receptor-positive (ER+) breast cancers, researchers from The University of Texas M. D. Anderson Cancer Center report in Clinical Cancer Research.

SEATTLE –- The incidence of advanced breast cancer diagnosis among black women remained 30 percent to 90 percent higher compared to white women between 1992 and 2004, according to new findings by researchers at Fred Hutchinson Cancer Research Center. In addition, the disparity in the incidence of advance colorectal cancer actually widened over this time period as rates fell among whites but increased slightly among blacks.

The findings are published online in the inaugural issue of Springer's journal Hormones and Cancer, a publication of the Endocrine Society.

LA JOLLA, CA--Scientists at The Scripps Research Institute have discovered a potential new use for the drug closantel, currently the standard treatment for sheep and cattle infected with liver fluke. The new research suggests that the drug may be useful in combating river blindness, a tropical disease that is the world's second leading infectious cause of blindness for humans.

The study is scheduled for publication in an advance, online Early Edition of the journal Proceedings of the National Academy of Sciences (PNAS) during the week of February 8, 2010.

ANN ARBOR, MICH. – In a commentary appearing in this week's Journal of the American Medical Association, heart specialists at the University of Michigan Health System make a plea for clarity on the best approach for prescribing beta blockers before surgery.

INDIANAPOLIS -- In the first large-scale epidemiological study of elevator-related injuries in older adults in the United States, researchers from the Indiana University School of Medicine and an Ohio State University colleague report in the January 2010 issue of The Journal of Trauma Injury, Infection, and Critical Care on the frequency, nature and opportunities for prevention of these injuries.

AMES, Iowa -- A previous six-month study by Iowa State University researchers had indicated that consuming modest amounts of soy protein, rich in isoflavones, lessened lumbar spine bone loss in midlife, perimenopausal women. But now an expanded three-year study by some of those same researchers does not show a bone-sparing effect in postmenopausal women who ingested soy isoflavone tablets, except for a modest effect at the femoral (hip) neck among those who took the highest dosage.

BIRMINGHAM, Ala.-– New research from the University of Alabama at Birmingham (UAB) says low potassium levels produce an increased risk of death or hospitalization in patients with heart failure and chronic kidney disease (CKD).

In findings reported in January in Circulation: Heart Failure, a journal of the American Heart Association, the researchers say that even a mild decrease in serum potassium level increased the risk of death in this patient group.

BUFFALO, N.Y.-- In the wake of the earthquake in Haiti, University at Buffalo geography students are participating in a global effort to enhance the international response and recovery effort by helping to assess damage, using images hosted by Google Earth and the Virtual Disaster Viewer, which shares imagery of disasters from various sources.

Vesicular stomatitis virus, or VSV, has long been a model system for studying and understanding the life cycle of negative-strand RNA viruses, which include viruses that cause influenza, measles and rabies.

More importantly, research has shown that VSV has the potential to be genetically modified to serve as an anti-cancer agent, exercising high selectivity in killing cancer cells while sparing healthy cells, and as a potent vaccine against HIV.

People with cystic fibrosis, an inherited disease that clogs airways with thick mucous, frequently have lung infections that defy treatment. While the life expectancy for children with cystic fibrosis has increased over the past few decades, many lives are still shortened in young adulthood by the ravages of lung infections.