"Patients with PAD experience foot pain, called 'claudication,' while walking," adds Gautam Shrikhande, M.D., assistant professor of surgery, and director of the Vascular Laboratory at Columbia's Medical Center. "This pain continues, even at rest, as the disease progresses. In more advanced stages, PAD patients develop sores or ulcers that won't heal. Then, cell death, a.k.a. 'gangrene,' occurs and amputation is often the only solution. It's extremely important to diagnose PAD early, because medication and lifestyle changes can alleviate the disease."