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"Flexibility and pragmatism are necessary to reduce the unacceptably high rates of unnecessary deaths in Africa because blood for transfusion is lacking," according to a group of 20 international authors from high, middle and low-income countries writing in this week's PLOS Medicine.

Among adults with asthma controlled with low-dose inhaled corticosteroid therapy, the time to treatment failure was not significantly different among patients who received corticosteroid dose adjustment based on physician assessment, a biomarker, or symptom occurrence, according to a study in the September 12 issue of JAMA.

In an analysis of the cost-savings achieved by an earlier pilot program, the Medicare Physician Group Practice Demonstration (PGPD), researchers found modest estimates of overall savings associated with the PGPD, but larger savings among the dually eligible patients (Medicare and Medicaid), with savings achieved in large part through reductions in hospitalizations, according to a study in the September 12 issue of JAMA.

GALVESTON, Texas Sept. 6, 2012 – New research has shown that the millions of people who use corticosteroids prescribed daily to control mild asthma do no better than those who use them only when symptoms occur.

For two decades, asthma treatment for millions of people with a milder form of the disease has consisted of daily inhaled steroid medicine to reduce inflammation. Now, a new study has found that asthmatics who take the low-dose medication as a daily routine do no better than those who turn to their inhalers only when they have symptoms.

The findings suggest a different, personalized, and far less expensive approach to treating the common inflammatory condition, according to the researchers.

A gene that may possibly belong to an entire new family of oncogenes has been linked by researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) to the resistance of breast cancer to a well-regarded and widely used cancer therapy.

LA JOLLA, CA, September 11, 2012 – Scientists at The Scripps Research Institute have found a new technique that should greatly speed the discovery of medically and scientifically useful antibodies, immune system proteins that detect and destroy invaders such as bacteria and viruses. New methods to discover antibodies are important because antibodies make up the fastest growing sector of human therapeutics; it is estimated that by 2014 the top-three selling drugs worldwide will be antibodies.

WEST LAFAYETTE, Ind. – Researchers have created a new type of miniature pump activated by body heat that could be used in drug-delivery patches powered by fermentation.

SAN FRANCISCO, CA—September 11, 2012—Scientists at the Gladstone Institutes have gotten us one step closer to understanding and overcoming one of the least-understood mechanisms of HIV infection—by devising a method to precisely track the life cycle of individual cells infected with HIV, the virus that causes AIDS.

A groundbreaking survey of Pakistanis has found stronger support for militant groups among the middle class than the poor. The finding by a team including Princeton researchers challenges the conventional wisdom about links between economic status and views on militants that has helped shaped American foreign-aid policies since 2001.

Boston – One third of American women of childbearing age are battling obesity, a condition that affects their health and their chances of getting pregnant. Obese women often have poor reproductive outcomes, but the reasons why have not been clearly identified. Now, a novel study led by Catherine Racowsky, PhD, director of the Assisted Reproductive Technologies Laboratory at Brigham and Women's Hospital (BWH), and performed by Ronit Machtinger, M.D., of BWH, in collaboration with Catherine Combelles, PhD, of Middlebury College, gains further insight into the underlying mechanisms.

When reminded of money (not cost), consumers are more likely to evaluate a new product based on its primary features or brand name, according to a new study in the Journal of Consumer Research.

PROVIDENCE, R.I. [Brown University] — A novel set of custom-designed "molecular beacons" allows scientists to monitor gene expression in living populations of stem cells as they turn into a specific tissue in real-time. The technology, which Brown University researchers describe in a new study, provides tissue engineers with a potentially powerful tool to discover what it may take to make stem cells transform into desired tissue cells more often and more quickly. That's a key goal in improving regenerative medicine treatments.

WHAT:

The genetic sequencing and reconstruction of the 1918 influenza virus that killed 50 million people worldwide have advanced scientists' understanding of influenza biology and yielded important information on how to prevent and control future pandemics, according to a new commentary by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and several other institutions.

By including chemotherapy as a conditioning regimen prior to treatment, researchers have developed a refined gene therapy approach that safely and effectively restores the immune system of children with a form of severe combined immunodeficiency (SCID), according to a study published online today in