Body

WINSTON-SALEM, N.C. – Oct. 15, 2012 – When patients suffering from Acute Myeloid Leukemia (AML) express high levels of the gene, MN1, an already aggressive leukemia is accelerated and shortens survival time. While that's a known fact, the mechanisms involved aren't well understood which is why a Wake Forest Baptist Medical Center researcher decided to take a closer look.

COLUMBIA, Mo. — Currently, large doses of chemotherapy are required when treating certain forms of cancer, resulting in toxic side effects. The chemicals enter the body and work to destroy or shrink the tumor, but also harm vital organs and drastically affect bodily functions. Now, scientists at the University of Missouri have proven that a new form of prostate cancer treatment that uses radioactive gold nanoparticles, and was developed at MU, is safe to use in dogs.

PITTSBURGH, Oct. 15, 2012 – An increased risk of autism spectrum disorders (ASD) could result from an accumulation of many small, common genetic variations rather than large-effect, rare changes in the genetic code, according to a multicenter team led by researchers at the University of Pittsburgh School of Medicine. Their findings, published today in Molecular Autism, provide new insights into the genetic factors that underlie the neurodevelopmental condition.

Exercise and healthy eating reduce body fat and preserve muscle in adults better than diet alone, according to a study funded and conducted by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The study was recently published online in Obesity and will be in a future print edition.

URBANA – Adding the right prebiotic to the diets of pediatric patients with intestinal failure could replace intravenous feeding, says a new University of Illinois study.

"When we fed the carbohydrate fructooligosacharide (FOS) as a prebiotic, the gut grew and increased in function," said Kelly A. Tappenden, a U of I professor of nutrition and gastrointestinal physiology. "The study showed that using the correct pre- and probiotic in combination could enhance these results even more."

For 50 years, the world's soybean crop has depended on the use of cyst nematode resistant varieties of beans, but no one knew how these plants fought off the nematode pests. Now, the secrets of resistant soybean plants are finally coming to light. Surprisingly, one of the genes related to nematode resistance in soybeans also has been associated with human diseases including lymphocytic leukemia, spina bifida and cardiovascular disease, according to a team of University of Missouri researchers and their colleagues whose breakthrough was recently published in the journal Nature.

This press release is available in Spanish.

Preventing activity of a key enzyme in potatoes could help boost potato quality by putting an end to cold-induced sweetening, according to U.S. Department of Agriculture (USDA) scientists.

Cold-induced sweetening, which occurs when potatoes are put in long-term cold storage, causes flavor changes and unwanted dark colors in fried and roasted potatoes. But long-term cold storage is necessary to maintain an adequate supply of potatoes throughout the year.

BEER-SHEVA, ISRAEL, October 15, 2012 -- Fearful flyers seek flight attributes that may be primarily reassuring, such as schedule, aircraft size and carrier origin, but have little effect on the low, actual risk according to a study published in the Journal of Travel Research.

People with fear of flying (FOF) are willing to pay more for a number of choices that help them alleviate their fear, according to the study by researchers at Ben-Gurion University of the Negev (BGU), The Hebrew University of Jerusalem and Technion Israel Institute of Technology.

DENVER – A study, published in the November 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, showed the plasma test VeriStrat can predict response but not survival benefit from erlotinib. The study was conducted on a subset of patients enrolled in the NCIC Clinical Trials Group, BR.21 phase III trial of erlotinib versus placebo in previously treated advanced non-small cell lung cancer patients.

DENVER – The International Mesothelioma Interest Group (IMIG) staging system has been widely used, however, widespread concerns exist about the validity of the current malignant pleural mesothelioma (MPM) staging system. Concerns include that the system is derived from analysis of small, retrospective surgical series; it can be difficult to apply to clinical staging; and uses descriptors for lymph node involvement, which may not be relevant to MPM.

DENVER – Until there are more validated biomarkers to direct treatment decisions, many physicians use patient age to decide what therapy to give their patients. Literature data report that older patients often go undertreated because of concerns for limited tolerance to toxic therapies. A study, published in the November 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, says that fit elderly non-small cell lung cancer (NSCLC) patients should be considered for salvage targeted therapy.

As the implementation of green roofs increase, a University of Cincinnati pilot study examined which plants best thrive on the Southwest Ohio region's roofs during the dry, hot conditions of summer.

That research, by UC biology student Jill Bader and Ishi Buffam, assistant professor of biology, identified a North American (and Ohio) native plant – nodding wild onion (Allium cernuum) and a European sedum (Sedum acre, also known as goldmoss sedum) as suited to survive and thrive on the region's green roofs.

A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the first to document the presence of the protein flagellin in house dust, bolstering the link between allergic asthma and the environment.

Scientists from the NIH's National Institute of Environmental Health Sciences (NIEHS) and Duke University Medical Center published their findings in people and mice online Oct. 14 in the journal Nature Medicine.

DETROIT – Wayne State University School of Medicine researchers may have discovered why people exposed to war are at increased risk to develop chronic problems like heart disease years later. And the culprit that links the two is surprising.

An analysis of a school behavior strategy—known as School-Wide Positive Behavioral Interventions and Supports (SWPBIS)—found that these types of programs significantly reduced children's aggressive behaviors and office discipline referrals, as well as improved problems with concentration and emotional regulation. The study, conducted by researchers from the Johns Hopkins Bloomberg School of Public Health, is the first randomized control trial to examine the impact of SWPBIS programs over multiple school years.