Body

ANN ARBOR—Nisin, a common food preservative, may slow or stop squamous cell head and neck cancers, a University of Michigan study found.

What makes this particularly good news is that the Food and Drug Administration and the World Health Organization approved nisin as safe for human consumption decades ago, says Yvonne Kapila, the study's principal investigator and professor at the University of Michigan School of Dentistry.

The UK Government has recently imposed a ban on importing foreign ash trees in order to prevent the spread of fungal disease Chalara, which kills the trees and has entered the country via imports from Europe.

Imperial College London researchers argue that the nursery trade, horticultural stakeholders and the plant buying public need to be more aware of the risks to tree health posed by imported plant pathogens. They say it is far better to prevent the entry of a tree disease than to attempt to contain it once it is established.

Blocking the action of a particular protein in our skin could improve the treatment of skin cancers, according to a study published in Oncogene yesterday by Philippe Roux, a researcher at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC). "Our findings reveal part of the mechanisms responsible for the resistance of melanoma to anti-cancer treatments, and suggest that a particular protein in our bodies called RSK may be targeted in combination therapies to overcome drug resistance," Roux explained.

CLEVELAND – A first-of-its-kind clinical trial conducted at University Hospitals (UH) Case Medical Center Seidman Cancer Center has shown encouraging results for the use of stereotactic radiosurgery to treat kidney cancer. This non-invasive treatment technique may represent a potential new non-surgical option for patients with this deadly disease who have limited treatment options.

In response to the on-line publication by the European Journal of Human Genetics today (Wednesday) of an article by US researchers led by Dr. Robert Cook-Degan, a former member of the US Office of Technology Assessment, showing that Myriad Genetics, providers of the BRCA1/2 genetic test in the US, has amassed vast quantities of clinical data without sharing it, Professor Martina Cornel, chair of the European Society of Human Genetics' Professional and Public Policy committee, said:

There is an urgent need for new drugs to treat Rett syndrome, a rare and severe neurological disease mainly affecting girls. A bottleneck in drug development for this syndrome is a lack of clarity at the level of preclinical research. Key researchers in this field now tackle this issue, proposing standards and guidelines for Rett syndrome research, in an Open Access review article published on Oct. 31, 2012 in Disease Models & Mechanisms (DMM) at http://dmm.biologists.org/.

BOSTON – Elevated risk of miscarriage, preterm birth, neonatal health complications and possible longer term neurobehavioral abnormalities, including autism, suggest that a class of antidepressants known as selective serotonin reuptake inhibitors (SSRI) should only be prescribed with great caution and with full counseling for women experiencing depression and attempting to get pregnant, say researchers at Beth Israel Deaconess Medical Center, Tufts Medical Center and MetroWest Medical Center.

The risk of maternal complications and preterm deliveries is significantly higher for women undergoing their fifth or more caesarean section, finds a new study published today (31 October) in BJOG: An International Journal of Obstetrics and Gynaecology.

The study explored the incidence of UK women having Multiple Repeat Caesarean Sections (MRCS), defined as five or more, and the outcomes for them and their babies compared to women having their second to fourth caesarean section.

Low calorie foods may help people lose weight but there is often a problem that people using them do not feel full. New research published in BioMed Central's open access journal Flavour shows that subtle manipulations of texture and creamy flavour can increase the expectation that a fruit yoghurt drink will be filling and suppress hunger regardless of actual calorific content.

DETROIT - Waiting too long after a hysterectomy to begin radiation therapy may increase the risk of uterine cancer recurrence, according to a new study from researchers at Henry Ford Hospital in Detroit.

The study shows that for patients with uterine cancer not receiving chemotherapy, tumors were more likely to return if radiation therapy was delayed nine weeks or longer following surgery, with only 43 percent having relapse-free survival after five years.

New research has found that the transport of proteins into chloroplasts in plants is differentially regulated by the age of the chloroplast; upturning the previously accepted notion that this process is age-independent or only globally up- or down- regulated for all proteins. The research, led by Dr. Hsou-min Li, a Research Fellow from the Institute of Molecular Biology, Academia Sinica of Taiwan, is published October 30 in the open access journal PLOS Biology.

Eliminating bacteria's DNA and boosting antimicrobial proteins that already exist may help prevent middle ear infections from reoccurring. These are the findings from a Nationwide Children's Hospital study that examined how an immune defense protein common in the middle ear interacts with a structure meant to protect a colony of bacteria.

Researchers at Case Western Reserve University have found a way to create three-dimensional maps of the stress that circulating blood places on the developing heart in an animal model – a key to understanding triggers of heart defects.

The team has begun testing the technology to uncover how alcohol, drugs and other factors set off events that result in defects found in newborn humans.

CLEVELAND, Ohio (October 29, 2012)—A new analysis of the Women's Health Initiative (WHI) trials show that women who had metabolic syndrome before they started hormone therapy had a greatly increased risk of heart attack or dying of heart disease. Women who didn't have metabolic syndrome beforehand showed no increased risk. The study was published this month online in Menopause, the journal of the North American Menopause Society.

Eat a breakfast sandwich and your body will be feeling the ill effects well before lunch – now that's fast food!

High-fat diets are associated with developing atherosclerosis (narrowing of the arteries) over a lifetime. But how quickly can damage start?

Just one day of eating a fat-laden breakfast sandwich – processed cheese and meat on a bun – and "your blood vessels become unhappy," says Heart and Stroke Foundation researcher Dr. Todd Anderson, director of the Libin Cardiovascular Institute of Alberta and head of cardiac science at the University of Calgary.