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Climate change is known to affect the population dynamics of single species, such as reindeer or caribou, but the effect of climate at the community level has been much more difficult to document. Now, a group of Norwegian scientists has found that extreme climate events cause synchronized population fluctuations among all vertebrate species in a relatively simple high arctic community. These findings may be a bellwether of the radical changes in ecosystem stability that could result from anticipated future increases in extreme events.

CAMBRIDGE, Mass. (January 17, 2013) – Using only a computer, an Internet connection, and publicly accessible online resources, a team of Whitehead Institute researchers has been able to identify nearly 50 individuals who had submitted personal genetic material as participants in genomic studies.

(Embargoed) CHAPEL HILL, N.C. – Histone proteins are the proteins that package DNA into chromosomes. Every time the cell replicates its DNA it must make large amounts of newly made histones to organize DNA within the nucleus.

An imbalance in the production of DNA and histones is usually lethal for the cell, which is why the levels of the messenger RNA (mRNA) encoding the histone proteins must be tightly controlled to ensure the proper amounts of histones (not too many and not too few) are made.

In contrast to climate change, there is no coordinated global system in place for measuring and reporting on biodiversity change or loss. An international team of biologists is now addressing this gap.

In Science today, 30 researchers led by Henrique Miguel Pereira, from the Centre for Environmental Biology of the University of Lisbon, proposed a global biodiversity monitoring system based on a set of essential variables.

Toronto -- Early life exposure to normal bacteria of the GI tract (gut microbes) protects against autoimmune disease in mice, according to research published on-line in the January 17 edition of Science. The study may also have uncovered reasons why females are at greater risk of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and lupus compared to males.

Often, employees are shocked by what they think is a supervisor's severe reaction to a subordinate's seemingly minor transgression. The supervisors who punish them seem to be so absolutely sure that they are doing the right thing—they have a clear sense of purpose and there are no arguments to sway them.

The enormously diverse complexity seen amongst individual species within the animal kingdom evolved from a surprisingly small gene pool. For example, mice effectively serve as medical research models because humans and mice share 80-percent of the same protein-coding genes. The key to morphological and behavioral complexity, a growing body of scientific evidence suggests, is the regulation of gene expression by a family of DNA-binding proteins called "transcription factors." Now, a team of researchers with the U.S.

The enormous complexity of biological processes requires the use of high­performance technologies —also known as '­omics'—, that are capable of carrying out complete integrated analyses of the thousands of molecules that cells are made up of, and of studying their role in illnesses. In the post-genomic age we find ourselves in, the comprehensive study of cellular proteins —prote-omics— acquires a new dimension, as proteins are the molecular executors of genes and, therefore, the most important pieces of the puzzle if we wish to understand more completely how cells work.

A research team with the Faculty of Medicine & Dentistry at the University of Alberta reported findings that significantly improve understanding of how widely used drugs in Pulmonary Arterial Hypertension (PAH) affect the heart health of treated patients.

The research shows that medications often prescribed for PAH could block the function of an important hormone in the heart, decreasing the strength of contraction of the right heart chambers, a potentially important and yet unrecognized adverse effect.

Biomedical researchers studying aging and cancer are intensely interested in telomeres, the protective caps on the ends of chromosomes. In a new study, scientists at UC Santa Cruz used a novel technique to reveal structural and mechanical properties of telomeres that could help guide the development of new anti-cancer drugs.

Leprosy is a bacterial disease that spreads to muscles and other tissues in the body, causing neurodegeneration and muscle weakness. A new study, published by Cell Press January 17th in the journal Cell, reveals that the bacteria responsible for leprosy spread infection by hijacking specialized cells in the adult nervous system, reprogramming them into a stem cell-like state, and converting them to muscle-like cells.

Scientists at Karolinska Institutet in Sweden have made a large step towards the understanding of how human genes are regulated. In a new study, published in the journal Cell, they identified the DNA sequences that bind to over four hundred proteins that control expression of genes. This knowledge is required for understanding of how differences in genomes of individuals affect their risk to develop disease.

Researchers at the University of California, San Diego School of Medicine have identified a molecular mechanism regulating autophagy, a fundamental stress response used by cells to help ensure their survival in adverse conditions.

The findings are published online in the January 17 issue of Cell.

Senior author Kun-Liang Guan, PhD, a professor of pharmacology at UC San Diego Moores Cancer Center, and colleagues report that an enzyme called AMPK, typically involved in sensing and modulating energy use in cells, also regulates autophagic enzymes.

Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive – and thus vulnerable – to a novel cancer stem cell-targeting drug currently under development.