Body

Protein 'filmed' while unfolding at atomic resolution

By combining low temperatures and NMR spectroscopy, the scientists visualized seven intermediate forms of the CylR2 protein while cooling it down from 25°C to -16°C. Their results show that the most instable intermediate form plays a key role in protein folding. The scientists' findings may contribute to a better understanding of how proteins adopt their structure and misfold during illness.

Underage youth drinking concentrated among small number of brands

A relatively small number of alcohol brands dominate underage youth alcohol consumption, according to a new report from researchers at the Boston University School of Public Health and the Center on Alcohol Marketing and Youth (CAMY) at the Johns Hopkins Bloomberg School of Public Health. The report, published online by Alcoholism: Clinical & Experimental Research, is the first national study to identify the alcohol brands consumed by underage youth, and has important implications for alcohol research and policy.

Study finds difficulty obtaining pricing, varying costs for total hip replacement

Researchers who sought to determine whether pricing information for a total hip replacement could be obtained from hospitals and physicians found getting such information was often difficult and that there were wide variations in the quoted prices, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.

Study confirms recurrence of small-for-gestational-age pregnancies

In a study to be presented on February 16 between 8 a.m., and 10 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, researchers will report findings that suggest women whose babies are small-for-gestational-age (SGA) in their first pregnancy have a strongly increased risk for SGA in a second pregnancy.

Study prompts rethink of how ovaries develop

New research from the University of Adelaide will rewrite the textbooks on how an ovary is formed, as well as providing new insights into women's health and fertility.

The study, now published in the journal PLOS ONE, also names a new type of cell that plays a key role in the development of ovaries and ovarian follicles, which are responsible for the production of eggs in women.

First-in-man study demonstrates the therapeutic effect of RNAi gene silencing in cancer treatment

The new study published in Cancer Discovery, the flagship journal of the American Association of Cancer Research (AACR), involving three Spanish and six American research centres, presents significant results in treating cancer patients with nanoparticles containing ribonucleic acid interference (RNAi) molecules. This marks the first time that the therapeutic effect of RNAi has been demonstrated in humans.

Studying bed bug actions for new management tactics

Learning more about the behavior of bed bugs is one approach being used by U.S. Department of Agriculture (USDA) scientists to identify compounds to help control these pests.

Presence of intra-amniotic debris a risk for early preterm birth in first pregnancy

In a study to be presented on February 14 between 8 a.m. and 10 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, California, researchers will report findings suggesting an increased risk of early (less than 35 weeks) preterm birth when intra-amniotic debris is present in nulliparous women with a short cervix. The babies born to women with debris had worse outcomes than those born to women without debris, likely due to the earlier delivery.

Can simple measures of labile soil organic matter predict corn performance?

Organic matter is important for soil health and crop productivity. While an indicator of soil quality, a lot of organic matter is in extremely stable forms, and the nutrients in such forms are difficult for plants to use. The active, labile fraction, however, is a modest but important part of the organic matter.

Study finds planned C-sections provide no advantage over planned vaginal birth of twins

In a study to be presented on February 14 between 8 a.m., and 10 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, researchers will report findings that suggest that planned birthing of twins at 32-38 weeks by cesarean section does not decrease perinatal or neonatal death compared to planned vaginal birth.

Study suggests tightening up of criteria for definition of intrauterine growth restriction

In a study to be presented on February 14 between 1:15 p.m., and 3:30 p.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, researchers will report that the practice of using an arbitrary Estimated Fetal Weight (EFW) less than the 10th centile may not be an efficient practice for defining true Intrauterine Growth Restriction (IUGR).

Policy changes in elective delivery proven successful

In a study to be presented on February 14 between 1:15 p.m., and 3:30 p.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, California, researchers will present data showing changes in elective delivery policy have been successful in reducing elective deliveries prior to 39 weeks.

Better outcome for frozen embryo replacement vs IVF

In a study to be presented on February 14 between 1:15 p.m., and 3:30 p.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, California, researchers will present findings showing perinatal outcomes of frozen/thawed embryo replacement (FER) have better outcomes compared to fresh in vitro fertilization (IVF), but worse outcomes compared to the non-IVF general population.

Preemptive treatment of severe morning sickness decreases suffering for moms-to-be

`In a study to be presented on February 14 between 1:15 p.m., and 3:30 p.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, California, researchers will present data showing the effectiveness of preemptive treatment for hyperemesis gravidarum and severe morning sickness.

Differences in obstetric outcomes and care related to race and ethnicity

In a study to be presented on February 14 between 1:15 p.m., and 3:30 p.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in San Francisco, California, researchers will present data showing racial and ethnic disparities exist for adverse obstetric outcomes.