Body

The sea-squirt derived drug trabectedin (ecteinascidinin-743) shows anti-tumour activity in more than half of patients with a specific type of cancer, conclude authors of an Article published early Online and in the July edition of The Lancet Oncology.

The programming language Fortran celebrates its 50th anniversary this year. To mark this occasion, a special issue of Scientific Programming on the role of Fortran is dedicated to Fortran creator John Backus and Ken Kennedy, pioneer of Fortran compiler optimization and parallelization. Both highly esteemed scientists died this year.

Scientists have long thought that microtubules, part of the microscopic scaffolding that the cell uses to move things around in order to hold its shape and divide, originated from a tiny structure near the nucleus, called the centrosome.

Women cheat on men for their own needs but superb starling females stray from their mates for the sake of their chicks, according to recent Cornell research. This reasoning includes being able to know if mates are too 'genetically similar' for breeding.

That gives 'doing it for the kids' a whole new layer of meaning. The study found that superb starling females (Lamprotornis superbus) cheat on their mates based on these factors:

Researchers say they have discovered the gene that regulates stem cell ability to self-renew and to differentiate into highly specialized types. This means they could program stem cells to become certain cells or do repair automatically.

“You could call this a ‘theory-of-everything’ for stem cells,” said senior author Dr. Michael Rudnicki, Senior Scientist and Professor at the Ottawa Health Research Institute and the University of Ottawa, referring to the often-cited theory of everything for physics.

A major question in evolutionary studies today is how early did humans begin to think and behave in ways we would see as fundamentally modern?

A new type of stainless steel alloy developed at Oak Ridge National Laboratory could allow for significantly increased operating temperatures and corresponding increases in efficiency in future energy production systems.

The new alloys offer superior oxidation resistance compared to conventional stainless steels, without significant increased cost or decreased creep resistance (sagging at high temperature). What sets this proprietary material apart from other stainless steels is its ability to form protective aluminum oxide scales instead of chromium oxide scales.

In a survey of more than one thousand infertility patients with frozen embryos, 60 percent of patients report that they are likely to donate their embryos to stem cell research, a level of donation that could result in roughly 2000 to 3000 new embryonic stem cell lines.

In August of 2001, less than two dozen embryonic stem cell lines were made eligible for federal research funding. Most scientists now agree that the eligible lines have proven inadequate in number and unsafe for transnational research.

The team of Denis Réale, Professor in the Department of Biological Sciences at Université du Québec à Montréal, recently published some remarkable research findings. Reconstructing the genetic history of a population of mouflons descended from a single pair, the researchers demonstrated that the animals’ genetic diversity increased over time, contrary to what the usual models predict.

These results contradict the belief that a population descended from a small number of individuals will exhibit numerous deficiencies and reduced genetic diversity.

The significance of pleiotrophin (PTN) expression in breast cancer has not been clearly established but researchers at Scripps sau they have done it in a new study. These new findings could lead to a better understanding of the molecular pathogenesis of breast cancer and focus attention on PTN and its signaling pathway as possible targets for new cancer therapies.

The obesity epidemic has become a major public health problem in both industrialized countries and the developing world. Recent studies suggest that the major development of persistent adiposity is established already at pre-adolescence.

The fact that obesity is mainly determined before puberty implies that preschool detection of children at risk is essential along with individual prevention programs.

Women who get most of their daily calcium from food have healthier bones than women whose calcium comes mainly from supplemental tablets, say researchers at Washington University School of Medicine in St. Louis. Surprisingly, this is true even though the supplement takers have higher average calcium intake.

Solving one of the biggest problems in commercialization of fuel-cell-powered automobiles is the goal of a new $1.88 million research project on on-board hydrogen storage at the U.S. Department of Energy's Argonne National Laboratory.

To be practical, researchers say, the hydrogen storage system must be able to hold enough of the fuel for a driving range of 300 miles before refilling; no current technology meets this goal within the constraints of allowable weight and volume for passenger cars.

While young people have been going to college in greater numbers over the past 20 years the Scottish higher education rate versus the English has been 'consistently and substantially' greater in Scotland, according to a unique study funded by the Economic and Social Research Council (ESRC).

The project, led by Dr Linda Croxford with Professor David Raffe of the University of Edinburgh, found that while the Scottish system encouraged young people to study beyond the age of 16, middle class students took most advantage.

Although it may sound like an oxymoron, a University of Iowa anthropologist and his colleagues report the first discovery of a skull from a "pygmy-sized" giant panda -- the earliest-known ancestor of the giant panda -- that lived in south China some two million years ago.

The ancestor of today's giant panda really was a pygmy giant panda, says Russell Ciochon, UI professor of anthropology. Previous discoveries of teeth and other remains made between 1985 and 2002 had failed to establish the animal's size.