Body

Scientists at Georgia Tech have developed a potential new treatment against cancer that attaches magnetic nanoparticles to cancer cells, allowing them to be captured and carried out of the body. The treatment, which has been tested in the laboratory and will now be looked at in survival studies, is detailed online in the Journal of the American Chemical Society.

PHILADELPHIA – Researchers have determined a novel mechanism through which organ transplantation often leads to cancer, and their findings suggest that targeted therapies may reduce or prevent that risk.

In the July 15, 2008, issue of Cancer Research, researchers at Harvard Medical School found in animal and laboratory experiments that the anti-rejection, immunosuppressive drug cyclosporine ramps up expression of vascular endothelial growth factor (VEGF), which signals the growth of new blood vessels that can feed tumors.

A study by researchers in Thailand, Japan, and the UK has shown a negative correlation between dengue hemorrhagic fever (DHF) and the density of the Aedes mosquitoes that transmit the virus. The study, published July 16th in the open-access journal PLoS Neglected Tropical Diseases, explains how current efforts to reduce the mosquitoes may actually increase the incidence of the potentially fatal viral disease.

A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible treatments. The novel cell line, described in the July 16 issue of PLoS ONE, will allow pharmaceutical companies to effectively test new drug candidates or possible vaccines for the HCV infection, which afflicts about 170 million people worldwide. Currently, there is no animal model that is effective for testing such therapies.

Female monkeys are more dominant when they live in groups with a higher percentage of males. This is caused by self-organisation. This surprising discovery was made by researchers at the University of Groningen. What makes the study particularly interesting is that the researchers used a computer model which can simulate interaction between monkeys. Their findings will be published on July 16 in the open-access journal PLoS ONE.

As frog populations die off around the world, researchers have identified certain genes that can help the amphibians develop resistance to harmful bacteria and disease. The discovery may provide new strategies to protect frog populations in the wild.

New work, published in the online, open-access journal PLoS ONE, examines how genes encoding the major histocompatibility (MHC) complex affect the ability of frogs to resist infection by a bacterium that is commonly associated with frog population declines.

Resistance to ciprofloxacin, a member of one of the most commonly used groups of antibiotics in the world, has been discovered by a team of Canadian researchers among people in remote South American villages who are believed to have never taken this medication. The findings are published July 16 in the online, open-access journal PLoS ONE.

40,000 years ago, the Cro-Magnoid people – the first people who had a skeleton that looked anatomically modern – entered Europe, coming from Africa. In the July 16 issue of the open-access journal PLoS ONE, a group of geneticists, coordinated by Guido Barbujani and David Caramelli of the Universities of Ferrara and Florence, shows that a Cro-Magnoid individual who lived in Southern Italy 28,000 years ago was a modern European, genetically as well as anatomically.

Hanover, NH-- Distinct genetic profiles can discern different groups of patients with scleroderma, a vexing autoimmune disease in which the body turns against itself, Dartmouth Medical School researchers report. Their discovery of distinguishing molecular subtypes within the disease offers new insight into the complexity of a poorly understood and hard to treat illness and opens a window for better diagnosis and targeted therapies.

Washington, DC – Researchers at Georgetown University Medical Center have discovered that vitamin A, when applied to breast cancer cells, turns on genes that can push stem cells embedded in a tumor to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply, promoting further tumor growth.

It is a staple of women's health advice and visits to the OB/GYN: the monthly breast self-exam to check for lumps or other changes that might signal breast cancer. However, a review of recent studies says there is no evidence that self-exams actually reduce breast cancer deaths.

Instead, the practice may be doing more harm than good, since it led to almost twice as many biopsies that turned up no cancer in women who performed the self-exams, compared to women who did not do the exams.

Two types of oxygen therapy could offer some relief to adults who suffer from disabling migraine and cluster headaches, according to a new research review from Australia.

Migraine headaches are severely painful and usually occur with other symptoms such as nausea, vomiting and painful sensitivity to light. Cluster headaches cause sharp, burning pain on one side of the head.

Custom-made insoles known as foot orthoses can reduce foot pain caused by arthritis, overly prominent big toe joints and highly arched feet, a new systematic review shows.

A team of Cochrane Researchers found that custom orthoses were safe interventions for foot pain in a number of different conditions. However, more research is required to develop an in depth understanding of their effectiveness.

People recover faster after surgery for ankle fracture if they are given a cast or splint that can be removed to let them exercise the ankle, than if their foot is placed in an immobilising plaster cast. If the fracture is stable, then encouraging them to walk soon after surgery is also beneficial. However, increased activity does increase the chance of experiencing problems with the surgical wound. These conclusions are published in a systematic review included in the latest update of The Cochrane Library.

Zinc supplementation benefits children suffering from diarrhoea in developing countries, but only in infants over six months old, Cochrane Researchers have found. Their study supports World Health Organization (WHO) guidelines for the treatment of diarrhoea with zinc, although not in the very young.

"Zinc is clearly of benefit to children with diarrhoea," says lead researcher Marzia Lazzerini, who works at the Unit of Research on Health Services and International Health in Trieste, Italy.