Body

KNOXVILLE -- Scientists at the University of Tennessee, Knoxville, and Lawrence Berkeley National Laboratory (LBNL) have published new findings about a cause of a condition at the root of genetic disorders such as Down Syndrome, pregnancy loss and infertility.

Called aneuploidy, the condition is an abnormal number of chromosomes, and the research team found that if a mother's egg cell has a mutation in just one copy of a gene, called Bub1, then she is less likely to have offspring that survive to birth.

Montreal, July 21, 2009 – Women who have premature menopause because of medical interventions are at an increased risk of developing lung cancer, according to a new study published in the International Journal of Cancer. The startling link was made by epidemiologists from the Université de Montréal, the Research Centre of the Centre Hospitalier de l'Université de Montréal and the INRS—Institut Armand-Frappier.

A sixteen-month study of consensus-based diagnosis of patients with disorders of consciousness has shown that 41% of cases of minimally conscious state (MCS) were misdiagnosed as vegetative state (VS), a condition associated with a much lower chance of recovery. Researchers writing in the open access journal BMC Neurology have demonstrated that standardized neurobehavioral assessment is more sensitive than diagnoses determined by clinical consensus.

African American men could be putting their health at risk by avoiding disease screening, in the belief that the results might threaten their masculinity. Because they prove their masculinity through their sexuality and sexual performance, seeking medical advice including HIV/AIDS testing goes against their notion of masculinity.

La Plata/Leipzig. Increasing numbers of children around the world are suffering from respiratory problems – coughing, wheezing and asthma attacks. Although the key external causes of these diseases were identified a long time ago (traffic and industrial air pollution), it had not previously been possible to distinguish clearly between these two factors so as to have a targeted impact on them.

A team of researchers from the Yale University (United States) and a Spanish company have developed a system to detect the vapours emitted by human skin in real time. The scientists think that these substances, essentially made up of fatty acids, are what attract mosquitoes and enable dogs to identify their owners.

Planarian flatworms are only a few millimeters up to a few centimeters in length, live in freshwater and are the object of intense research, because they possess the extraordinary ability to regenerate lost tissue with the help of their stem cells (neoblasts) and even grow an entirely new worm out of minute amputated body parts. Now researchers from the Max Delbrück Center in Berlin, Germany together with researchers in the US and Canada present the first comprehensive catalogue of small RNAs of planaria, elements that regulate gene expression.

Researchers at the University of Warwick have recovered significant DNA information from a lost form of ancient barley that triumphed for over 3000 years seeing off: 5 changes in civilisation, water shortages and a much more popular form of barley that produces more grains. This discovery offers a real insight into the couture of ancient farming and could assist the development of new varieties of crops to face today's climate change challenges.

To control mosquito-borne diseases like dengue, researchers need to look at the behavior of people, not just the insect that transmits the disease, according to new research by Steven Stoddard of the University of California, Davis, and intercollegiate colleagues. The study, published July 21 in the open-access journal PLoS Neglected Tropical Diseases, exhibits work by an international, multidisciplinary team of vector biologists, sociologists and virologists studying dengue in Iquitos, Peru.

In 1989 scientists identified the gene mutation that causes cystic fibrosis (CF), which led to the hope that CF lung disease could be 'cured' using gene therapy. The premise of gene therapy is that modified viruses or other gene-based systems could be used to deliver a corrected version of a gene into affected tissues. However, the projected cure has been hampered by the natural ability of the lung to limit the introduction of foreign genes into its cells.

David Moher, from the Ottawa Hospital Research Institute; University of Ottawa, and an international consortium of contributors publish the PRISMA guidelines: a set of tools developed to help authors improve the reporting of systematic reviews and meta-analyses. In order to ensure wide distribution, the guidelines are being published simultaneously in several medical journals: Annals of Internal Medicine, the BMJ, Journal of Clinical Epidemiology, Open Medicine, and PLoS Medicine.

Should the financial ties between doctors and drug companies be completely cut, or are healthy alliances between the two possible with the common aim of improving human health? A debate in this week's PLoS Medicine discusses whether the influence of drug company money on doctors is always a corrupting one.

CHAPEL HILL – Scientists have worked for 20 years to perfect gene therapy for the treatment of cystic fibrosis, which causes the body to produce dehydrated, thicker-than-normal mucus that clogs the lungs and leads to life threatening infections.

TUCSON, ARIZ. – It is an amazing sight: What looks like a tiny beating heart is actually a piece of synthetic, gauze-like mesh, barely the size of a fingernail, floating in a Petri dish. And yet it keeps squeezing away, nice and rhythmically.

Researchers at The University of Arizona's Sarver Heart Center and the Southern Arizona Veterans Administration Health Care System (SAVAHCS) have come a step closer to repairing hearts damaged by a heart attack or weakened by chronic heart failure.

Arctic springtails (Megaphorura arctica) survive freezing temperatures by dehydrating themselves before the coldest weather sets in. Researchers writing in the open access journal BMC Genomics have identified a suite of genes involved in controlling this extreme survival mechanism.