Body

Enzymes inside cells that normally repair damaged DNA sometimes wreck it instead, researchers at the Stanford University School of Medicine have found. The insight could lead to a better understanding of the causes of some types of cancer and neurodegenerative disease.

In a paper to be published online Nov. 27 in Molecular Cell, the researchers explain how the recently discovered mechanism of DNA damage occurs when genetic transcripts, composed of RNA, stick to the DNA instead of detaching from it.

Mutations in the KRAS gene have long been known to cause cancer, and about one third of solid tumors have KRAS mutations or mutations in the KRAS pathway. KRAS promotes cancer formation not only by driving cell growth and division, but also by turning off protective tumor suppressor genes, which normally limit uncontrolled cell growth and cause damaged cells to self-destruct.

SALT LAKE CITY--Researchers from Huntsman Cancer Institute (HCI) at the University of Utah (U of U) discovered the unusual role of lactate in the metabolism of alveolar soft part sarcoma (ASPS), a rare, aggressive cancer that primarily affects adolescents and young adults. The study also confirmed that a fusion gene is the cancer-causing agent in this disease. The research results were published online in the journal Cancer Cell Nov. 26, 2014.

A new paper, by Dr Stanley Blue, lecturer in Social Sciences at The University of Manchester, claims that there needs to be a shift in public health policy, with less focus on efforts to change individual behaviour and more attention on breaking social habits and practices that are blindly leading us into bad health.

CLEVELAND, Ohio (November 26, 2014)--Removing ovaries at hysterectomy does not increase a woman's risk of pelvic organ prolapse after menopause. In fact, removing ovaries lowers the risk of prolapse. This surprising finding from a Women's Health Initiative study was published online this week in Menopause, the journal of The North American Menopause Society (NAMS).

Hamilton, ON (Nov. 26, 2014) - McMaster University researchers have found that current evidence does not support the routine use of minimally invasive surgery to remove herniated disc material pressing on the nerve root or spinal cord in the neck or lower back.

In comparing it with open surgery, they found that while minimally invasive surgery for cervical or lumbar discectomy may speed up recovery and reduce post-operative pain, it does not improve long-term function or reduce long-term extremity pain.

The evolution of freshwater shrimps species living in both sides of Central America, isolated by the closure of Isthmus of Panama (3 million years ago) were studied by molecular tools. Despite the small likelihood of species crossing the Isthmus from one side to the other through the channel exist, the genetic isolation of them were maintained over the time and the separation of Pacific and Atlantic sister species still unchanged. Sister species refer to pairs of species that are genetically and morphologically closely related, but reproductively isolated.

An Andalusian team of researchers led by the University of Granada has demonstrated the efficacy of a new drug against cancerogenic stem cells, which cause the onset and development of cancer, of relapse after chemotherapy and metastasis. This drug, called Bozepinib, has proved to be effective in tests with mice. The results have been published in the prestigious journal Oncotarget.

Spam spreads much faster and to more people when it is being propagated by hacked, or otherwise compromised, email accounts rather than legitimate accounts, according to research published in the International Journal of Security and Networks. The insight should help those modeling the dynamics of information diffusion as well as those hoping to track and trace spam with a view to slowing or blocking its propagation. Spam traditionally contained ads for fake or counterfeit products, but currently also contains disruptive rumors and information of a political nature.

Long-sightedness caused by age could be due to proteins in the lens of the eye that are converted from a fluid solution to a solid, glassy state. This has been shown in a study by researchers from institutions including Lund University.

Around the age of 40-50, many people find their sight deteriorates and they need to use reading glasses. This age-related long-sightedness is thought to be due to a reduction in the elasticity of the lens in the eye. A new research study appears to have put its finger on the details of what happens in the eye when long-sightedness develops.

How do the genes in the cells inside the body's muscles respond when the muscles are put to work? And how are these genes affected when muscles are not used? What importance do activity and, on the other hand, lack of activity have for the organism's metabolism, and thus also for diseases such as diabetes and obesity?

DESPITE a sequence of stellar performances by Britain's female athletes and team game players, coverage of women's sport in the Press still occupies a fraction of the space given to men, according to University of Huddersfield lecturer Deirdre O'Neill, who has analysed thousands of articles in newspapers that she describes as a "football-saturated boyzone".

Enzymes are macromolecular biological catalysists that lead most of chemical reactions in living organisms. The main focus of enzymology lies on enzymes themselves, whereas the role of water motions in mediating the biological reaction is often left aside owing to the complex molecular behavior. The groups of Martina Havenith (Cluster of Excellence RESOLV - Ruhr explores Solvation) and Irit Sagi (Weizmann Institue of Science, Israel) revised the classical enzymatic steady state theory by including long-lasting protein-water coupled motions into models of functional catalysis.

A study reveals how little we know about the Amazonian diversity. Aiming to resolve a scientific debate about the validity of two species of freshwater shrimp described in the first half of the last century, researchers have found that not only this species is valid, but also discovered the existence of a third unknown species. The researchers concluded that these species evolved about 10 million years ago. The study was published in the open access journal ZooKeys.

An international team of scientists which includes researchers from the U. of Granada has demonstrated for the first time that it is possible to establish in an objective way the level of fatigue in physicians after long shifts through their eye movement.

This research reveals that the speed of saccadic movement (mostly voluntary rapid eye movements which we use to focus our gaze upon an object that attracts our attention) is an excellent index to measure objectively the level of fatigue in the medical profession.