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McGill University researchers have unlocked a new door to developing drugs to slow the progression of Parkinson's disease. Collaborating teams led by Dr. Edward A. Fon at the Montreal Neurological Institute and Hospital -The Neuro, and Dr. Kalle Gehring in the Department of Biochemistry at the Faculty of Medicine, have discovered the three-dimensional structure of the protein Parkin. Mutations in Parkin cause a rare hereditary form of Parkinson's disease and are likely to also be involved in more commonly occurring forms of Parkinson's disease.

Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.

Georgia Tech engineers and Emory University clinicians have successfully engrafted insulin-producing cells into a diabetic mouse model, reversing diabetic symptoms in the animal in as little as 10 days.

Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have established an inheritable bacterial infection in malaria-transmitting Anopheles mosquitoes that renders them immune to malaria parasites. Specifically, the scientists infected the mosquitoes with Wolbachia, a bacterium common among insects that previously has been shown to prevent malaria-inducing Plasmodium parasites from developing in Anopheles mosquitoes.

EAST LANSING, Mich. — Mosquitoes are deadly efficient disease transmitters. Research conducted at Michigan State University, however, demonstrates that they also can be equally adept in curing diseases such as malaria.

An article published recently in Tumor Microenvironment and Therapy - an open access journal by Versita, defines a novel mechanism of tumor hypoxia induced by the longitudinal gradient of residual oxygen along tumor vessels as they transverse the tumor.

Bacteria on a surface wander around and often organize into highly resilient communities known as biofilms. It turns out that they organize in a rich-get-richer pattern similar to many economies, according to a new study by researchers at UCLA, Northwestern University and the University of Washington.

PITTSBURGH, May 9, 2013 – A physician's choice of words when talking with family members about whether or not to try cardiopulmonary resuscitation (CPR) if a critically ill patient's heart stops may influence the decision, according to a study by University of Pittsburgh researchers in the June edition of Critical Care Medicine and now available online.

Coral reefs are in decline, but their collapse can still be avoided with local and global action. That's according to findings reported in the Cell Press journal Current Biology on May 9 based on an analysis that combines the latest science on reef dynamics with the latest climate models.

Heart failure is one of the most debilitating conditions linked to old age, and there are no specific therapies for the most common form of this condition in the elderly. A study published by Cell Press May 9th in the journal Cell reveals that a blood hormone known as growth differentiation factor 11 (GDF11) declines with age, and old mice injected with this hormone experience a reversal in signs of cardiac aging. The findings shed light on the underlying causes of age-related heart failure and may offer a much-needed strategy for treating this condition in humans.

HOUSTON -- (May 9, 2013) – Amoeba eat bacteria and other human pathogens, engulfing and destroying them – or being destroyed by them, but how these single-cell organisms distinguish and respond successfully to different bacterial classes has been largely unexplained.

Cambridge, MA, May 9, 2013 - Two Harvard Stem Cell Institute researchers – one a stem cell biologist and one a practicing cardiologist at Brigham and Women's Hospital – have identified a protein in the blood of mice and humans that may prove to be the first effective treatment for the form of age-related heart failure that affects millions of Americans.

When the protein, called GDF-11, was injected into old mice, which develop thickened heart walls in a manner similar to aging humans, the hearts were reduced in size and thickness, resembling the healthy hearts of younger mice.

SALT LAKE CITY—Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have discovered that while the genes provided by the father arrive at fertilization pre-programmed to the state needed by the embryo, the genes provided by the mother are in a different state and must be reprogrammed to match. The findings have important implications for both developmental biology and cancer biology.

Researchers from the RIKEN Center for Integrative Medical Sciences have identified a gene that when mutated is responsible for a spectrum of disorders affecting the bones and connective tissue. This finding opens new avenues for research into a diagnosis and treatment for these until now incurable diseases.

The study is published today in the American Journal of Human Genetics.

At the University of Geneva (UNIGE), the team led by Professor Jean Gruenberg has long been interested in the movement of lysosomes, the sub-compartments of cells to where endocytic vesicles deliver their waste content and the molecules destined to be destroyed. Within this context, researcher Christin Bissig, along with her international colleagues, carried out a detailed study of the route taken by Alix which is lodged inside the endosomal membrane.

May 9, 2013, New York, NY and San Diego, CA – A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human development.