Body

Novel drug action against solid tumors explained

(SACRAMENTO, Calif.) — Researchers at UC Davis, City of Hope, Taipai Medical University and National Health Research Institutes in Taiwan have discovered how a drug that deprives the cells of a key amino acid specifically kills cancer cells.

Their paper, published today in Proceedings of the Academy of Sciences, is the culmination of nearly a decade of research into the role of arginine – and its deprivation – in the generation of excessive autophagy, a process in which the cell dies by eating itself.

Study: New tool proves effective in evaluating doctor's bedside manner

TORONTO, ON, Aug 11, 2014 —The best way to improve a doctor's bedside manner may lie in a new tool that evaluates and helps medical residents improve their communication and other soft skills to become better doctors, according to a new study led by Women's College Hospital's Dr. Tim Dwyer.

The study, published in the latest issue of the Canadian Journal of Surgery, is the first to look at the medical residents' collaboration, communication and other soft skills, or what are known as CanMEDS competencies, in orthopedic surgical training.

Reconstructions show how some of the earliest animals lived -- and died

Rangeomorphs were unlike any modern organism, which has made it difficult to determine how they fed, grew or reproduced, and therefore difficult to link them to any particular modern group. However, despite the fact that they looked like plants, evidence points to the fact that rangeomorphs were actually some of the earliest animals.

Emergency gallbladder surgery: Do you need it, or can you afford to wait?

Rochester, Minn. — Gallstone pain is one of the most common reasons patients visit emergency rooms. Figuring out who needs emergency gallbladder removal and who can go home and schedule surgery at their convenience is sometimes a tricky question, and it isn't always answered correctly. A new Mayo Clinic study found that 1 in 5 patients who went to the emergency room with gallbladder pain and were sent home to schedule surgery returned to the ER within 30 days needing emergency gallbladder removal.

A vaccine alternative protects mice against malaria

A study led by Johns Hopkins Bloomberg School of Public Health researchers found that injecting a vaccine-like compound into mice was effective in protecting them from malaria. The findings suggest a potential new path toward the elusive goal of malaria immunization.

Highly drug resistant, virulent strain of Pseudomonas aeruginosa arises in Ohio

A team of clinician researchers has discovered a highly virulent, multidrug resistant form of the pathogen, Pseudomonas aeruginosa, in patient samples in Ohio. Their investigation suggests that the particular genetic element involved, which is still rare in the United States, has been spreading heretofore unnoticed, and that surveillance is urgently needed. The research is published ahead of print in Antimicrobial Agents and Chemotherapy.

Want to kill creativity of women in teams? Fire up the competition

Recent research has suggested that women play better with others in small working groups, and that adding women to a group is a surefire way to boost team collaboration and creativity.

But a new study from Washington University in St. Louis finds that this is only true when women work on teams that aren't competing against each other. Force teams to go head to head and the benefits of a female approach evaporate.

Synthetic molecule makes cancer self-destruct

Researchers from The University of Texas at Austin and five other institutions have created a molecule that can cause cancer cells to self-destruct by ferrying sodium and chloride ions into the cancer cells.

These synthetic ion transporters, described this week in the journal Nature Chemistry, confirm a two-decades-old hypothesis that could point the way to new anticancer drugs while also benefitting patients with cystic fibrosis.

New study: Ravens rule Idaho's artificial roosts

A new study by the Wildlife Conservation Society (WCS), U.S. Geological Survey (USGS) and Idaho State University (ISU) explored how habitat alterations, including the addition of energy transmission towers, affect avian predators nesting in sagebrush landscapes.

Researchers compared nesting habitat selection between Common Ravens and three raptor species commonly found in sagebrush ecosystems: Red-tailed Hawks, Swainson's Hawks, and Ferruginous Hawks.

Stanford researchers uncover cancer-causing mechanism behind powerful human oncogene

A protein present at high levels in more than half of all human cancers drives cell growth by blocking the expression of just a handful of genes involved in DNA packaging and cell death, according to a new study by researchers at the Stanford University School of Medicine.

How breast cancer usurps the powers of mammary stem cells

During pregnancy, certain hormones trigger specialized mammary stem cells to create milk-producing cells essential to lactation. Scientists at the University of California, San Diego School of Medicine and Moores Cancer Center have found that mammary stem cells associated with the pregnant mammary gland are related to stem cells found in breast cancer.

Malaria medicine chloroquine inhibits tumor growth and metastases

A recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. This blood vessel normalization results in an increased barrier function on the one hand -- thereby blocking cancer cell dissemination and metastasis -- and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

CRI scientists pinpoint gene likely to promote childhood cancers

DALLAS – Aug. 11, 2014 – Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified a gene that contributes to the development of several childhood cancers, in a study conducted with mice designed to model the cancers. If the findings prove to be applicable to humans, the research could lead to new strategies for targeting certain childhood cancers at a molecular level. The study was published today in the journal Cancer Cell.

US immigration is associated with rise in smoking among Latinos and Asians

Immigration to the U.S. may result in increased smoking in Latino and Asian women, according to new research from sociologists at Rice University, Duke University and the University of Southern California.

mmunosensory system: Keeping viruses at bay

Our immunosensory system detects virus such as influenza via specific characteristics of viral ribonucleic acid. Previously, it was unclear how the immune system prevents viruses from simply donning molecular camouflage in order to escape detection. An international team of researchers from the University of Bonn Hospital and the London Research Institute have now discovered that our immunosensory system attacks viruses on a molecular level. In this way, a healthy organism can keep rotaviruses, a common cause of diarrheal epidemics, at bay.