Body

Researchers at Cleveland Clinic have discovered that a gene – known as an androgen receptor (AR) – is found in both prostate and breast cancers yet has opposite effects on these diseases.

In prostate cancer, the AR gene promotes cancer growth when the gene is "turned on." In breast cancer, the AR gene promotes cancer growth when the gene is "turned off," as is often the case after menopause, when AR production ceases in women.

Lung cancer patients with diabetes tend to live longer than patients without diabetes, according to a Norwegian study published in the November issue of the Journal of Thoracic Oncology, the official publication of the International Association for the Study of Lung Cancer.

Researchers did not speculate on the reason for the effect, but said that the survival benefit warranted more study and that diabetes should not be considered a reason to withhold standard cancer treatment.

Poly-3-hydroxybutyrate (PHB) is a thermoplastic polyester which occurs naturally in bacteria as Ralstonia eutropha and Bacillus megaterium. Even though PHB is biodegradable and is not dependent on fossil resources, this bioplastic has been traditionally too expensive to produce to replace petroleum-based plastics. New research reported in BioMed Central's open access journal Microbial Cell Factories describes an alternative method of producing PHB in microalgae.

Coral reefs are among the most diverse ecosystems on the planet, second only to tropical rain forests. Bird's nest coral (Seriatopora hystrix) is common throughout the Indo-Pacific and is able to live across a range of depths. However, there is little gene flow between the coral populations at each depth and even the algal endosymbionts (Symbiodinium), which provide energy for the corals to survive, are genetically different across habitats.

In the mid-nineteenth century, John Snow mapped cases of cholera in Soho, London, and traced the source of the outbreak to a contaminated water pump. Now, in a twenty-first century equivalent, scientists funded by the Wellcome Trust working in Kathmandu, Nepal, have combined the latest in gene sequencing technology and global positioning system (GPS) case localisation to map the spread of typhoid and trace its source.

Scientists have discovered an enzyme that acts as a 'fertility switch', in a study published in Nature Medicine today. High levels of the protein are associated with infertility, while low levels make a woman more likely to have a miscarriage, the research has shown.

COLUMBUS, Ohio - For the first time, researchers have found a way to inject a precise dose of a gene therapy agent directly into a single living cell without a needle.

The technique uses electricity to "shoot" bits of therapeutic biomolecules through a tiny channel and into a cell in a fraction of a second.

L. James Lee and his colleagues at Ohio State University describe the technique in the online edition of the journal Nature Nanotechnology, where they report successfully inserting specific doses of an anti-cancer gene into individual leukemia cells to kill them.

Researchers in South East Asia have identified two genetic variants associated with increased susceptibility to severe dengue. The study, funded by the Wellcome Trust and the Agency for Science, Technology, and Research, Singapore, offers clues to how the body responds to dengue infection.

Researchers have identified a large number of areas in the human genetic code that are involved in regulating the way in which the liver functions, in a new study of over 61,000 people, published today in the journal Nature Genetics.

Cold Spring Harbor, N.Y. – At the same time that a cell's DNA gets duplicated, a third of it gets super-compacted into repetitive clumps called heterochromatin. This dense packing serves to repress or "silence" the DNA sequences within—which could wreck the genome if activated—as well as regulate the activity of nearby genes. When the cell divides, the daughter cells not only inherit a copy of the mother cell's DNA, but also the exact pattern in which that DNA is clumped into heterochromatin.

Knee injuries in children with tears of the anterior cruciate ligament (ACL) and meniscus have increased dramatically over the past 12 years, say orthopaedic surgeons from The Children's Hospital of Philadelphia who presented their findings today at the American Academy of Pediatrics annual meeting in Boston.

HOUSTON -- (October 13, 2011) – Ordinarily, embryonic stem cells exist only a day or two as they begin the formation of the embryo itself. Then they are gone.

In the laboratory dish, however, they act more like perpetual stem cells – renewing themselves and exhibiting the ability to form cells of almost any type, a status called totipotency.

By studying mice exposed to tobacco smoke for a period of months, researchers have new insight into how emphysema and chronic obstructive pulmonary disease (COPD) develops. In the October 14th issue of Cell, a Cell Press publication, they also report a promising new way to reverse the lung damage underlying these conditions.

BOSTON – Pulse oximetry, a non-invasive procedure that measures the amount of oxygen in the bloodstream, can be used as a screening tool to detect critical congenital heart disease (CCHD) in infants, and is more readily available than echocardiography, the current gold standard for CCHD diagnosis, according to a new research abstract presented Friday, Oct. 14, at the American Academy of Pediatrics (AAP) National Conference and Exhibition (NCE) in Boston.

An international team of scientists led by Monash University researchers has uncovered how a common hospital bacterium becomes a deadly superbug that kills increasing numbers of hospital patients worldwide and accounts for an estimated $3.2 billion each year in health care costs in the US alone. Their findings appear October 13th in the Open Access journal PLoS Pathogens.