Body

Research on Priceline-style Web sites favors package deals, says Management Insights

Allowing joint bidding helps reduce potential mismatch between an e-tailer's costs and the consumer's bids on name-your-own-price websites like Priceline, according to the Management Insights feature in the current issue of Management Science, the flagship journal of the Institute for Operations Research and the Management Sciences (INFORMS).

Management Insights, a regular feature of the journal, is a digest of important research in business, management, operations research, and management science. It appears in every issue of the monthly journal.

Weight does not affect women's sexual behavior

CORVALLIS, Ore. – Oregon and Hawaiian researchers have found that a woman's weight does not seem to affect sexual behavior. In fact, overweight women are more likely to report having sex with men than women considered to be of "normal weight."

Friend or foe? How the body's clot-busting system speeds up atherosclerosis

Sometimes it's hard to tell friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged arteries by generating clot-busting plasmin from blood-derived plasminogen.

Study identifies 3 effective treatments for childhood anxiety disorders

Treatment that combines a certain type of psychotherapy with an antidepressant medication is most likely to help children with anxiety disorders, but each of the treatments alone is also effective, according to a new study funded by the National Institutes of Health's National Institute of Mental Health (NIMH). The study was published online Oct. 30, in the New England Journal of Medicine.

Newly identified fungus implicated in white-nose syndrome in bats

A previously undescribed, cold-loving fungus has been linked to white-nose syndrome, a condition associated with the deaths of over 100,000 hibernating bats in the northeastern United States. The findings are published in this week's issue of Science.

The probable cause of these bat deaths has puzzled researchers and resource managers urgently trying to understand why the bats were dying in such unprecedented numbers. Since the winter of 2006-07, bat declines at many surveyed hibernation caves exceeded 75 percent.

UC San Diego biologists discover a motor protein that rewinds DNA

Two biologists at the University of California, San Diego have discovered the first of a new class of cellular motor proteins that "rewind" sections of the double-stranded DNA molecule that become unwound, like the tangled ribbons from a cassette tape, in "bubbles" that prevent critical genes from being expressed.

"When your DNA gets stuck in the unwound position, your cells are in big trouble, and in humans, that ultimately leads to death" said Jim Kadonaga, a professor of biology at UCSD who headed the study. "What we discovered is the enzyme that fixes this problem."

Conclusive proof that polar warming is being caused by humans

New research by the University of East Anglia (UEA) has demonstrated for the first time that human activity is responsible for significant warming in both polar regions.

The findings by a team of scientists led by UEA's Climatic Research Unit will be published online by the Nature Geoscience this week.

Virginia Tech engineers identify conditions that initiate erosion

Blacksburg, Va. -- Wind, water, and waves erode billions of tons of soil from the earth's surface. As a result, many rivers are plagued with excessive amounts of suspended sediment. According to the U.S. Environmental Protection Agency, such eroded sediment is the largest nonpoint source pollution in the environment.

Ultrafast lasers give CU-Boulder researchers a snapshot of electrons in action

In the quest to slow down and ultimately understand chemistry at the level of atoms and electrons, University of Colorado at Boulder and Canadian scientists have found a new way to peer into a molecule that allows them to see how its electrons rearrange as the molecule changes shape.

Transplantation: 'molecular miscegenation' blurs the boundary between self and non-self

A new discovery by London biologists may yield new ways of handling the problem of transplant rejection. In a research article published in the November 2008 print issue of The FASEB Journal (http://www.fasebj.org), the scientists confirm the two-way transfer of a molecule (called "MHC") that instructs the immune system to tell "self" from "non-self." By disrupting the transfer of this molecule, newly transplanted organs should become "invisible" to the host's immune system.

Optimal dose of vitamin E maximizes benefits, minimizes risk

Corvallis, Oregon – October 29, 2008 -- Vitamin E has been heralded for its ability to reduce the risk of blood clots, heart attack, and sudden death. Yet in some people, vitamin E causes bleeding. Scientists have known for more than 50 years that excess vitamin E promotes bleeding by interfering with vitamin K, which is essential in blood clotting. However, they haven't been able to pinpoint how the two vitamins interact.

UC Davis researchers discover a key to aggressive breast cancer

(SACRAMENTO, Calif.) — In trying to find out why HER2-positive breast cancer can be more aggressive than other forms of the disease, UC Davis Cancer Center researchers have surprisingly discovered that HER2 itself is the culprit. By shutting down its own regulator gene, HER2 creates a permissive environment for tumor growth.

Building on recent research showing that the regulator — labeled LRIG1 and commonly called "Lig-1" — limits the growth-promoting signals of HER2, the research team set out to clarify the role of Lig-1 in breast cancer.

Complete mitochondrial genome of 5,000-year-old mummy yields surprise

Researchers have revealed the complete mitochondrial genome of one of the world's most celebrated mummies, known as the Tyrolean Iceman or Ötzi. The sequence represents the oldest complete DNA sequence of modern humans' mitochondria, according to the report published online on October 30th in Current Biology, a Cell Press publication.

Mitochondria are subcellular organelles that generate all of the body's energy and house their own DNA, which is passed down from mother to child each generation. Mitochondrial DNA thus offers a window into our evolutionary past.

Following the Phoenicians: Genetic methodology complements historical record

A new study uses a sophisticated genetic strategy to reveal new roads past an apparent dead end in the historical record of a distinctive civilization that dominated the Mediterranean Sea during the first millennium BC. The research from National Geographic and IBM's Genographic Project, published by Cell Press in the November 14th issue of the American Journal of Human Genetics, describes a methodology that may prove to be useful for discovering previously undetected signals left by migrations for any historically documented expansion.

Ancient mummy has no modern children

The 5,300 year old human mummy – dubbed Öetzi or 'the Tyrolean Iceman' – is highly unlikely to have modern day relatives, according to new research published today.

A team comprising scientists from Italy and the UK has sequenced Öetzi's entire mitochondrial DNA (mtDNA) genome - which is passed down through the maternal line – and found that he belonged to a genetic lineage that is either extremely rare, or that has died out.