Body

Genes associated with fat metabolism could increase kidney cancer risk

WASHINGTON, D.C. - A team of international scientists has identified three genes associated with the body's processing of fats that may increase susceptibility to kidney cancer. The findings were presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

Why only some former smokers develop lung cancer

WASHINGTON, D.C. - Canadian researchers are trying to answer why some smokers develop lung cancer while others remain disease free, despite similar lifestyle changes.

Results were presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

According to the Centers for Disease Control and Prevention, more people die from lung cancer than any other cancer type. In fact, according to 2004 data, more people died from lung cancer than breast, prostate and colon cancers combined.

Breast cancer common among women with family history but without BRCA1 or BRCA2

WASHINGTON, D.C. - New data presented at the American Association for Cancer Research's Seventh Annual International Frontiers in Cancer Prevention Research meeting outlines new data, which assesses breast cancer risk among women with a strong family history of breast cancer, but without a BRCA1 or BRCA2 mutation. This may facilitate earlier detection and prevention among high-risk women.

3 esophageal, stomach cancer subtypes linked to smoking; 1 associated with alcohol use

WASHINGTON, D.C. - Researchers who have been following the health of more than 120,000 residents of the Netherlands for more than two decades have found that smoking is associated with two forms of esophageal cancer as well as a form of stomach cancer, and that drinking alcohol is strongly linked to one form of esophageal cancer.

Genetic risk factors may tailor prostate cancer screening approaches

Men with a family history of prostate cancer and African-American men are particularly susceptible to the disease, with a twofold to sevenfold increased risk. Assessing risk in these populations has been difficult.

"There have been years of effort to try to identify genes and genetic mutations associated with prostate cancer as there are for breast cancer," said Veda N. Giri, M.D., director of the Prostate Cancer Risk Assessment Program (PRAP) at Fox Chase Cancer Center, Philadelphia. "Prostate cancer is a more genetically complex disease."

CAPHOSOL results in minimal oral mucositis and pain in head/neck cancer patients

SEATTLE, Wash., November 15, 2008 – New data show that CAPHOSOL® (www.caphosol.com), an advanced electrolyte solution, results in low rates of oral mucositis and pain in patients with head and neck (HN) cancer who are undergoing chemotherapy and radiation therapy.

Money motivates doctors to reduce ethnic differences in heart disease treatments

Financial incentives for doctors can improve the management of coronary heart disease (CHD) and reduce ethnic differences in quality of and access to care, according to Dr. Christopher Millett, Consultant in Public Health at Imperial College Faculty of Medicine in London in the UK, and his colleagues. Their evaluation(1) of the benefits of pay for performance schemes in the UK for the management of coronary heart disease, with a particular focus on ethnic differences, has just been published online in Springer's Journal of General Internal Medicine.

Calls for a more flexible approach to vaccine funding

Including quality-of-life impacts in assessments of national vaccination programs would lead to many benefits, including improved productivity and less sick leave for parents, according to an editorial co-authored by a University of New South Wales (UNSW) researcher, that has appeared in the Lancet Infectious Diseases.

Such initiatives would also protect others in society, while getting the maximum impact of population vaccination programs.

Floppy-footed gibbons help us understand how early humans may have walked

The human foot is a miracle of evolution. We can keep striding for miles on our well-sprung feet. There is nothing else like them, not even amongst our closest living relatives. According to Evie Vereecke, from the University of Liverpool, the modern human foot first appeared about 1.8 million years ago, but our ape-like ancestors probably took to walking several million years earlier, even though their feet were more 'floppy' and ape like than ours.

Why HIV treatment makes people so susceptible to heart disease and diabetes

Clinicians have known for some time that people treated for HIV also become much more susceptible to diabetes and heart disease. A study by scientists at Sydney's Garvan Institute of Medical Research has now shown some of the reasons why – enabling better patient management and monitoring.

Study helps clarify role of vitamin D in cancer therapy

A colon cancer cell isn't a lost cause. Vitamin D can tame the rogue cell by adjusting everything from its gene expression to its cytoskeleton. In the Nov. 17 issue of the Journal of Cell Biology, Ordóñez-Morán et al. show that one pathway governs the vitamin's diverse effects. The results help clarify the actions of a molecule that is undergoing clinical trials as a cancer therapy.

Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth

JACKSONVILLE, Fla. — Two critical properties of cancer cells are their ability to divide without restraint and to spread away from the primary tumor to establish new tumor sites. Now, researchers from the Mayo Clinic campus in Florida have found a protein they say acts as a deadly master switch, both freeing cancer cells from a tumor while ramping up new growth.

Breaking BubR1 mimics genetic shuffle seen in cancer cells

PHILADELPHIA (Nov. 17, 2008) – A study of how one protein enzyme, BubR1, helps make sure chromosomes are equally distributed during mitosis might explain how the process of cell division goes so awry in cancer, according to researchers from Fox Chase Cancer Center. Their findings might offer a better understanding of the processes behind cancer-cell survival and drug-resistance.

Gene chips accurately detect pneumonia in ICU patients on ventilators

Nov. 17, 2008 -- Even seasoned doctors have a difficult time diagnosing pneumonia in hospitalized patients breathing with the assistance of a ventilator. That's because a patient's underlying illness often skews laboratory test results and masks pneumonia's symptoms.

Sonography in space

Los Angeles, London, New Delhi, Singapore and Washington DC (November 14, 2008) Astronauts on extended space missions can get injured or develop diseases, necessitating immediate diagnosis and treatment. Research conducted on the International Space Station (ISS) ensuring that astronauts could accurately perform remotely-guided sonograms was published in the November/December 2008 issue of the Journal of Diagnostic Medical Sonography (published by SAGE).