Body

Mechanisms of cardiovascular disease and cancer give clues to new therapies

Cardiovascular conditions leading to heart attacks and strokes are treated quite separately from common cancers of the prostate, breast or lung, but now turn out to involve some of the same critical mechanisms at the molecular level. This in turn provides clues to more effective therapies for both cancer and cardiovascular diseases, but requires researchers in these distinct fields to come together.

Access to the future

The cranes have been dismantled and the muddy paths have given way to an attractive park: inHaus2 is finished. "At least finished as far as construction is concerned," specifies Klaus Scherer of the Fraunhofer Institute for Microelectronic Circuits and Systems IMS, who heads the inHaus innovation center in Duisburg. "In terms of research and development, on the other hand, we are far from reaching the end. All the exciting projects planned with our application partners are now about to begin, and the labs, as we call them, have been or are being set up."

Heart patients are often not treated in accordance with guidelines

Many patients with cardiovascular disease are not given adequate drug therapy. This is the result of an international study. In the current edition of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2008; 105[45]: 769-75), Uwe Zeimer et al. present the German results of this prospective, one-year survey.

From genes to farmers' fields

Delhi, India – "Waterproof" versions of popular varieties of rice, which can withstand 2 weeks of complete submergence, have passed tests in farmers' fields with flying colors. Several of these varieties are now close to official release by national and state seed certification agencies in Bangladesh and India, where farmers suffer major crop losses because of flooding of up to 4 million tons of rice per year. This is enough rice to feed 30 million people.

New study data: JANUVIA (sitagliptin)

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NC State study shows bird population estimates are flawed

Most of what we know about bird populations stems from surveys conducted by professional biologists and amateur birdwatchers, but new research from North Carolina State University shows that the data from those surveys may be seriously flawed – and proposes possible means to resolve the problem.

Long-term antibiotics reduce COPD exacerbations, raise questions

Long-term use of a macrolide antibiotic may reduce the frequency of exacerbations in patients with moderate to severe chronic obstructive pulmonary disease (COPD) by as much as 35 percent, according to a London-based study.

"Our results show a significant effect of low-dose macrolide therapy, reducing exacerbation frequency and severity with moderate to severe COPD," wrote lead author of the paper, Terence A. R. Seemungal, Ph.D., and Jadwiga Wedzicha, M.D., principle investigator.

Fall babies: Born to wheeze?

It is said that timing is everything, and that certainly appears to be true for autumn infants. Children who are born four months before the height of cold and flu season have a greater risk of developing childhood asthma than children born at any other time of year, according to new research.

Scientists discover new species of Ebola virus

Scientists report the discovery of a new species of Ebola virus, provisionally named Bundibugyo ebolavirus, November 21 in the open-access journal PLoS Pathogens. The virus, which was responsible for a hemorrhagic fever outbreak in western Uganda in 2007, has been characterized by a team of researchers from the Centers for Disease Control and Prevention in Atlanta, Georgia the Uganda Virus Research Institute; the Uganda Ministry of Health; and Columbia University.

Pregnant women who do aquarobics have easier deliveries

A course of water aerobics classes has been shown to reduce the amount of pain-killing medication women request during labor. Research published in BioMed Central's open access journal Reproductive Health has shown that, as well as being safe, the gentle exercise has the benefit of making it easier to give birth.

Iressa proves just as effective as chemotherapy for lung cancer

HOUSTON - Gefitinib, also known as Iressa, the once-promising targeted therapy for the treatment of non-small cell lung cancer, has proven as effective as chemotherapy as a second-line therapy for the disease with far fewer side effects, according to an international Phase III clinical trial, led by researchers at The University of Texas M. D. Anderson Cancer Center.

However, in contrast to earlier Iressa findings, the study showed that there was no additional survival benefit for patients who expressed an elevated level of the epidermal growth factor receptor (EGFR) mutation.

US military technology protects critically endangered goliath grouper

Fort Pierce, Florida - November 19, 2008 - The Ocean Research & Conservation Association (ORCA) and its collaborators announced today the world's first use of an acoustic underwater camera to survey juveniles of goliath grouper in mangrove habitats.

Preventing tumor cells from refueling: A new anti-cancer approach?

New data, generated in mice, by Pierre Sonveaux and colleagues, at Université catholique de Louvain, Belgium, have identified a potential new target for anticancer therapeutics.

Lactic acid found to fuel tumors

DURHAM, N.C., and BRUSSELS, BELGIUM — A team of researchers at Duke University Medical Center and the Université catholique de Louvain (UCL) has found that lactic acid is an important energy source for tumor cells. In further experiments, they discovered a new way to destroy the most hard-to-kill, dangerous tumor cells by preventing them from delivering lactic acid.

Supercontinuum generation and soliton dynamics milestone achieved

A research team led by Fetah Benabid, University of Bath, has observed for the first time the simultaneous emission of two resonant dispersive waves by optical solitons (waves that maintain their shape while traveling at constant speeds). By designing a special fiber with an extremely small waveguiding feature located in the photonic crystal fiber cladding, the researchers were able to bring the theoretical prediction into the experimental demonstration, creating waves on both sides of the pump. This research appears in the current issue of the Optical Society's Optics Letters.