Serum creatinine-to- cystatin C ratio predicts mortality

In patients initiating continuous renal replacement therapy for acute kidney injury, higher serum creatinine-to-cystatin C ratios were associated with lower mortality.

Identifying risk factors for mortality in patients with acute kidney injury (AKI) receiving intensive care and continuous renal replacement therapy (CRRT) is useful for improving assessment of prognosis. In this study of 1,588 patients who underwent CRRT in a single tertiary center intensive care unit, the 30- and 90-day mortality risks were significantly lower in patients with higher creatinine:cystatin C ratio at the time CRRT was begun. This association remained after adjustment for confounding factors. These findings suggest that creatinine:cystatin C ratio may be a simple, useful tool for mortality risk assessment in critically ill patients who develop AKI.

National Kidney Foundation