Transforming growth factor-β1 is a universal multifunctional polypeptide cytokine, which has been shown to have a protective effect against nerve cell damage. Golgi morphology may be damaged after cerebral ischemia-reperfusion. Transforming growth factor-β1 exists in the Golgi apparatus of nerve cells, and further protects the Golgi apparatus. GM130 is an important matrix protein appearing on the Golgi surface, however, variation of GM130 expression during cerebral ischemia-reperfusion injury has not been studied yet. Yan Wang and colleagues from the Second Xiangya Hospital, Central South University, China elucidated changes in morphology, protein expression and function of Golgi and its molecular mechanisms in a rat model of cerebral ischemia-reperfusion injury after administration with Danhong injection. The researchers found that Danhong injection can improve the expression of transforming growth factor beta 1 and GM130, and maintain the stability of neuronal Golgi morphology and structure after cerebral ischemia-reperfusion, thus exerting a neuroprotective effect. These findings were published in the Neural Regeneration Research (Vol. 8, No. 25, 2013).
The Golgi apparatus were normal in morphology and stained deeply after administration with Danhong injection in rats with cerebral ischemia- reperfusion injury (immunohistochemical staining, × 400).
(Photo Credit: Neural Regeneration Research)
Source: Neural Regeneration Research