June's SLAS discovery features the special collection, 'ion channels and relevant drug screening approaches'

image: Cover of June's SLAS Discovery

Image: 
David James Group

Oak Brook, IL - The June issue of SLAS Discovery features a special collection of research reviews and perspectives curated by the journal's Editorial Board.

In this issue, Guest Editor Veli-Pekka Jaakola, Ph.D., (Confo Therapeutics, Belgium) highlights a series of articles focused on new screening tools and assays that find new chemical matter for medically relevant membrane protein targets. In addition, an overview of a new and emerging protein-lipid reconstitution methodology utilizing styrene maleic acid (SMA) polymers is featured.

Articles in the special collection include:

Screening Technologies for Inward Rectifier Potassium Channels: Discovery of New Blockers and Activators

Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Nav1.7 Inhibitors

Application of High-Throughput Automated Patch-Clamp Electrophysiology to Study Voltage-Gated Ion Channel Function in Primary Cortical Cultures

Image-Based Marker-Free Screening of GABAA Agonists, Antagonists, and Modulators

Applied Biophysical Methods in Fragment-Based Drug Discovery

Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences

A Novel Inhibition Modality for Phosphodiesterase 2A

Development of a Cell-Based Immunodetection Assay for Simultaneous Screening of Antiviral Compounds Inhibiting Zika and Dengue Virus Replication

The Impact of Variable Selection Coverage on Detection of Ligands from a DNA-Encoded Library Screen

Exploring the Lower Limit of Individual DNA-Encoded Library Molecules in Selection

Credit: 
SLAS (Society for Laboratory Automation and Screening)