Nucleoli (green), small liquid-like nuclear bodies, are kept small and afloat by a fine actin mesh. When the mesh breaks, the nucleoli quickly being to fall and coalesce into larger droplets at the bottom of the nucleus. The grid size is 50 microns.
(Photo Credit: Marina Feric and Cliff Brangwynne, Princeton University)
Two different RNP droplets, nucleoli (red) and histone locus bodies (HLBs) (green), are suspended in the nucleus of the frog oocyte by a nuclear actin mesh. Disrupt the mesh and these nuclear bodies immediately start falling, the nucleoli sinking faster because of their larger size and higher density. The grid size is 50 microns.
(Photo Credit: Videos courtesy of Marina Feric & Cliff Brangwynne, Princeton University)