Oak Brook, IL - The February edition of SLAS Discovery is a Special Issue on Hit Discovery Methodologies edited by Mark Wigglesworth, Ph.D., (Medicines Discovery Catapult, Stockport, EN, UK) and Peter Hodder, Ph.D. (Amgen, Thousand Oaks, CA, USA).
The focus of this Special Issue is to highlight the use of hit discovery methodologies and technologies and their usage in both small molecule and large molecule drug discovery. The February issue exemplifies how technologies, both new and existing, have been applied successfully to find hits.
Additionally, the issue houses a list of the most downloaded articles from SLAS journals, many of which reflect the focus on the implementation, characterization and progression of hit discovery.
The February issue of SLAS Discovery includes nine articles of original research in addition to the cover article.
Articles of Original Research include:
A Homogeneous Cell-Based Membrane Potential Assay to Identify Compounds that Promote Readthrough of Premature Termination Codons in the Cystic Fibrosis Transmembrane Conductance Regulator Ion Channel
High-Throughput Screening and Triage Assays Identify Small Molecules Targeting cMyc in Cancer Cells
Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS)
Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging
High-Throughput Mechanism of Inhibition
AI Driven Iterative Screening for Hit Finding
Toward the Efficient Discovery of Actionable Chemical Matter From DNA-Encoded Libraries
An Automated High-Throughput Fluorescence in Situ Hybridization (FISH) Assay Platform for Use in the Identification and Optimization of siRNA-Based Therapeutics
Comparison of Approaches for Determining Bioactivity Hits from High-Dimensional Profiling Data
Other articles include:
European Lead Factory: Collaborative Innovation in Hit Discovery
High-Throughput Mass Spectrometry for Hit Identification: Current Landscape & Future Perspectives