Earth
First-in-class antispastic drug candidate to reach clinical phase is published in the prestigious life science journal, Cell. Drug candidate MPH-220 could mean new hope for millions of patients suffering from spasticity.
BOSTON - An experimental medication that was recently shown to slow the progression of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, has now demonstrated the potential to also prolong patient survival. The findings come from a clinical trial conducted by investigators at the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH) and Amylyx Pharmaceuticals, Inc., the company that manufactures the medication.
Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS' Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR.
Chestnut Hill, Mass. (10/16/2020) - The Southern Ocean played a critical role in the rapid atmospheric carbon dioxide increase during the last deglaciation that took place 20,000 to 10,000 years ago, according to a new report by Boston College geochemist Xingchen (Tony) Wang and an international team in the online edition of Science Advances.
In this new study, Wang and his coauthors analyzed deep-sea coral fossils from 20,000 to 10,000 years ago, when atmospheric carbon dioxide was on the rise.
New research published in Nature Communications Earth & Environment uses data from two sustained open-ocean hydrographic stations in the North Atlantic Ocean near Bermuda to demonstrate recent changes in ocean physics and chemistry since the 1980s. The study shows decadal variability and recent acceleration of surface warming, salinification, deoxygenation, and changes in carbon dioxide (CO2)-carbonate chemistry that drives ocean acidification.
Mammals and birds today are warm-blooded, and this is often taken as the reason for their great success.
University of Bristol palaeontologist Professor Mike Benton, identifies in the journal Gondwana Research that the ancestors of both mammals and birds became warm-blooded at the same time, some 250 million years ago, in the time when life was recovering from the greatest mass extinction of all time.
EAST LANSING, Mich. - Children's television programming not only shapes opinions and preferences, its characters can have positive or negative impacts on childhood aspiration, says a new study from Michigan State University.
The study is the first large-scale analysis of characters featured in science, technology, engineering and math-related educational programming. It was published in the fall 2020 edition of Journal of Children and Media. Results revealed that of the characters appearing in STEM television programming for kids ages 3 to 6, Latinx and females are left behind.
People who receive reminders of past misinformation may form new factual memories with greater fidelity, according to an article published in the journal Psychological Science.
Past research highlights one insidious side of fake news: The more you encounter the same misinformation--for instance, that world governments are covering up the existence of flying saucers--the more familiar and potentially believable that false information becomes.
With demand for lentils growing globally and climate change driving temperatures higher, a University of Saskatchewan-led international research team has developed a model for predicting which varieties of the pulse crop are most likely to thrive in new production environments.
An inexpensive plant-based source of protein that can be cooked quickly, lentil is a globally important crop for combatting food and nutritional insecurity.
The fossilised remains of ancient deep-sea corals may act as time machines providing new insights into the effect the ocean has on rising CO2 levels, according to new research carried out by the Universities of Bristol, St Andrews and Nanjing and published today [16 October] in Science Advances.
NEW YORK - October 16, 2020 - A new observational study of deferred lesions following combined fractional flow reserve (FFR) and coronary flow reserve (CFR) assessments found that untreated vessels with abnormal FFR but intact CFR do not have non-inferior outcomes compared to those with an FFR greater than 0.8 and a CFR greater than or equal to two when treated medically.
The cover for issue 30 of Oncotarget features Figure 4, "RNAseq results demonstrating differences between normal, cancer, and redirected cells," by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not.
All good things must come to an end. Whether societies are ruled by ruthless dictators or more well-meaning representatives, they fall apart in time, with different degrees of severity. In a new paper, anthropologists examined a broad, global sample of 30 pre-modern societies. They found that when "good" governments--ones that provided goods and services for their people and did not starkly concentrate wealth and power--fell apart, they broke down more intensely than collapsing despotic regimes.
October 15, 2020 - Nutley, NJ - A patient with end-stage and rapidly progressing soft-tissue cancer whose tumor did not respond to standard treatment, had a "rapid and complete response" to a novel combination of immunotherapy, according to new research published by a team of scientists from John Theurer Cancer Center at Hackensack University Medical Center and the Georgetown Lombardi Comprehensive Cancer Center, both of whom are part of the Georgetown Lombardi Comprehensive Cancer Center Consortium.
Sophia Antipolis, 16 Oct 2020: More than two-thirds of deaths from heart disease worldwide could be prevented with healthier diets. That's the finding of a study published today in European Heart Journal - Quality of Care and Clinical Outcomes, a journal of the European Society of Cardiology (ESC).1
The findings come on World Food Day, which highlights the importance of affordable and sustainable healthy diets for all.