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Volume XX, Issue XX from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and reduced cellular migration and invasion.
Altogether, the research team's findings document TQs effect on colorectal cancer stem-like cells and provide insights into its underlying mechanism of action.
Scientists have developed a white paint that cools below the temperature of its ambient surroundings even under direct sunlight. Their research, published October 21 in the journal Cell Reports Physical Science, demonstrates a radiative cooling technology that could be used in commercial paints, that could be less expensive to manufacture, and that passively reflects 95.5% of sunlight that reaches its surface back into outer space.
Low levels of key, body-regulating chemicals in mothers during the first three months of pregnancy may interfere with the baby's brain development, a large American study shows.
These chemicals, or hormones, are produced in the thyroid gland in the neck and are known to influence fetal growth. Investigators have suspected that disruptions in their production, or hypothyroidism, may contribute to attention deficit/hyperactivity disorder (ADHD), which is the most common neurodevelopmental disorder of children in the U.S.
A small amount of molten rock located under tectonic plates encourages them to move. This is what scientists from the Laboratoire de géologie de Lyon: Terre, planètes et environnement (CNRS/ENS de Lyon/Université Claude Bernard Lyon 1) have recently discovered. Their new model takes into account not only the velocity of seismic waves but also the way in which they are attenuated by the medium they pass through. The velocity of tectonic plates near the surface is thus directly correlated with the quantity of magma present. This research is published on October 21, 2020 in Nature.
CHAPEL HILL, NC - October 21, 2020 - Babies born with a faulty maternal copy of the UBE3A gene will develop Angelman syndrome, a severe neurodevelopmental disorder with no cure and limited treatments. Now, for the first time, scientists at the UNC School of Medicine show that gene editing and gene therapy techniques can be used to restore UBE3A in human neuron cultures and treat deficits in an animal model of Angelman syndrome.
Although the diverse treatment methods developed to effectively treat cancer, chemotherapy using anticancer agents has been proven especially effective in many clinical applications. Above all, it is more affordable than other treatment methods and is effective against most types of cancer, which is why it is most common approach to treat disease.
Papyrus FMNH31324 was acquired by the Field Museum of Natural History in Chicago on May 24, 1894, after collector Edward E. Ayer purchased the papyrus for the museum while in Europe.
CHAMPAIGN, Ill. --Genome editing of human embryos represents one of the most contentious potential scientific applications today. But what if geneticists could sidestep the controversy by editing sperm and eggs instead?
According to a new paper co-written by a University of Illinois at Urbana-Champaign legal expert who studies the ethical and policy implications of advanced biotechnologies, how the next Congress decides to handle the issue will affect the science, ethics and financing of genome editing for decades to come.
Some people love spicy food -- the hotter, the better. Others go out of their way to avoid the palate-singeing burn of capsaicin, the compound that gives chili peppers their kick. Now, researchers have developed a portable device (whimsically shaped like a chili pepper) that can reveal how much capsaicin a pepper contains, before biting into it. They report their results in ACS Applied Nano Materials.
The virus wreaking havoc on our lives is an efficient infection machine. Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, SARS-CoV-2 is expertly evolved to trick our cells to contribute its machinery to assist in its propagation.
In the last few months, scientists have learned a great deal about the mechanics of this mindless enemy. But what we've learned still pales in comparison to what we don't know.
Climate change pushes species distribution areas northward. However, the expansion of species ranges is not self-evident due to e.g. habitat degradation and unsustainable harvesting caused by human activities. A new study led from the University of Turku, Finland, suggests that protected areas can facilitate wintering waterbird adaptation to climate warming by advancing their range shifts towards north.
For many cancers, doctors are increasingly looking to the DNA that solid tumors shed into the blood stream to help with diagnosis and monitoring. But brain cancer has been a different story thanks to the natural blockade created by the blood-brain barrier.
Researchers at the University of Michigan Rogel Cancer Center and Michigan Medicine C.S. Mott Children's Hospital, however, were optimistic that cerebrospinal fluid could be a valuable source for tumor DNA that could help monitor and treat pediatric cancer patients with aggressive brain tumors known as high-grade gliomas.
A new analysis of nine years of nationwide data examines the impacts of the Black Lives Matter movement on fatal interactions with police, and on crime and arrests.
Results from a study published in the Journal of Biogeography indicate that wildfires may play a role in accelerating climate-driven species changes in mountain forests by compounding regional warming trends.
WEST LAFAYETTE, Ind. - Purdue University innovators are taking cues from nature to develop 3D photodetectors for biomedical imaging.
The Purdue researchers used some architectural features from spider webs to develop the technology. Spider webs typically provide excellent mechanical adaptability and damage-tolerance against various mechanical loads such as storms.