Culture
Detailed analysis from the epicentre of the Italian COVID-19 outbreak describes increase in cases of rare Kawasaki-like disease in young children, adding to reports of similar cases from New York, USA and South East England, UK. Syndrome is rare and experts stress that children remain minimally affected by SARS-CoV-2 infection overall.
Harvard University scientists have identified a new gut-brain connection in the neurodegenerative disease amyotrophic lateral sclerosis, or ALS. The researchers found that in mice with a common ALS genetic mutation, changing the gut microbiome using antibiotics or fecal transplants could prevent or improve disease symptoms.
Published in the journal Nature, the findings provide a potential explanation for why only some individuals carrying the mutation develop ALS. They also point to a possible therapeutic approach based on the microbiome.
Whilst the whole world is in lockdown during the current Corona crisis, certain cells within our bodies are still travelling long-distance: while this happens when you develop pneumonia, any ordinary cut on your finger will also trigger white blood cells--aka leukocytes--to instantly move out of your blood vessels into the site of inflammation. Similarly, cancer cells, which can originate in any tissue or organ, can also spread and reproduce far away from their place of origin. The result: a metastasis.
Researchers at Karolinska Institutet in Sweden have compared two ways of delivering cognitive behavioral therapy, CBT, to treat people with health anxiety, a condition that may increase in the wake of COVID-19. Out of about 200 study participants, half received CBT over the Internet and half were treated with conventional face-to-face CBT. The results, published in JAMA Psychiatry, show that Internet-delivered treatment had comparable effects, and could serve as an alternative to physical meetings in helping people who are worried about their health.
What The Study Did: This study combined the results of 57 studies with 7,000 participants to examine how effective are interventions and programs to enhance the social, emotional and spiritual aspects of wisdom.
Authors: Dilip V. Jeste, M.D., of the University of California, San Diego in La Jolla, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamapsychiatry.2020.0821)
A study led by researchers at the Babraham Institute in collaboration with the Wellcome Sanger Institute has uncovered how variations in a non-protein coding 'dark matter' region of the genome could make patients susceptible to complex autoimmune and allergic diseases such as inflammatory bowel disease. The study in mice and human cells reveals a key genetic switch that helps immune responses remain in check.
What The Study Did: Professional medical societies recommend certain genetic tests for individuals with autism spectrum disorder (ASD). This study looked at how common it was for nearly 1,300 individuals diagnosed with ASD to undergo these tests and the factors associated with receiving genetic testing.
Authors: Eric M. Morrow, M.D., Ph.D., of Brown University in Providence, Rhode Island, is the corresponding author.
MINNEAPOLIS - It's never too late to lace up some sneakers and work up a sweat for brain health, according to a study published in the May 13, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study suggests older adults, even couch potatoes, may perform better on certain thinking and memory tests after just six months of aerobic exercise.
What The Review Says: The characteristics, treatment and outcomes of heart transplant recipients who were infected with COVID-19 in New York City are described in this case series.
Authors: Nir Uriel, M.D., M.Sc., of Columbia University Irving Medical Center and Weill Cornell Medicine in New York, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamacardio.2020.2159)
Doctors regularly warn their patients that having high levels of triglycerides, a major dietary fat, can increase the risk of heart disease, diabetes, obesity and fatty liver disease. There is considerable interest in finding novel ways to effectively regulate triglycerides in the blood to help manage these potentially life-threatening common conditions.
By studying samples from two independent clinical trials of malaria vaccines, Gemma Moncunill and colleagues have linked signatures in the immune system to better vaccine protection from the disease in children and adults. Their analysis of the RTS,S vaccine and sporozoite immunization provides generalizable benchmarks that future studies could use to evaluate the effectiveness of malaria vaccine candidates. Malaria continues to pose a huge health burden around the world, with an estimated 218 million cases in 2018.
In 2015 Francesco Greco, head of the Laboratory of Applied Materials for Printed and Soft electronics (LAMPSe) at the Institute of Solid State Physics at Graz University of Technology, developed so-called "tattoo electrodes" together with Italian scientists. These are conductive polymers that are printed using an inkjet printer on standard tattoo paper and then stuck to the skin like transfers to measure heart or muscle activity.
Viruses are ubiquitous pathogens that cause severe infectious diseases in both humans and agricultural crops. As most viruses have simple genomes and encode only a few proteins, they must usurp host cell resources for propagation. Understanding what host processes are disrupted and which viral proteins are involved greatly facilitate the design of therapeutic measures for controlling viral diseases in humans and crop plants.
Microplastics are everywhere - including in our drinking water, table salt and in the air that we breathe. Having studied the scope of microplastics in a number of countries, researchers are worried.
- Given the lifetime inevitable exposure to microplastics, we urgently call for a better understanding of the potential hazards of microplastics to human health, says Dr Elvis Genbo Xu, an Assistant Professor of environmental toxicology at the University of Southern Denmark.
Historically, amphetamine-like drugs such as FDA-approved phentermine have been some of the most popular anti-obesity drugs that have ever been prescribed. They work in the brain by suppressing appetite but, besides being addictive, can also have dangerous side effects such as increased heart rate, hypertension and hyperthermia.