Culture
Advances in the Production of Minor Ginsenosides Using Microorganisms and Their Enzymes - BIO Integration
https://bio-integration.org/wp-content/uploads/2020/05/bioi20200007.pdf
Announcing a new article publication for BIO Integration journal. In this review article the author Almando Geraldi from the Universitas Airlangga, Indonesia considers the advances in the production of minor ginsenosides using microorganisms and their enzymes.
Buried deep within the varied properties of metals, there is a fundamental question up for grabs: What makes it a metal? In other words, which properties are inherent to a metal and which are incidental?
Scientists at USC Dornsife College of Letters, Arts and Sciences, collaborating with an international group of researchers, have helped further define what constitutes a metal. In the process, they open the door for organic chemists to improve the synthesis of useful compounds.
The study appears on the cover of the journal Science on June 5.
A collaborative project between the Center for Genome Integrity, within the Institute for Basic Science (IBS, South Korea), and the Dundee School of Life Sciences, the EMBL's European Bioinformatics Institute (EMBL-EBI), and the Wellcome Sanger Institute (UK) have screened almost 163,000 DNA mutations in 2,700 C. elegans roundworms to shed light on DNA damage. The results, published in Nature Communications, lead to the conclusion that mutation patterns seen in cancer are more complicated than we previously thought.
Genome-wide association studies (GWAS) analyse a genome-wide set of genetic variants in different individuals to see if any are associated with a trait or disease. Such studies are getting larger and larger and, in some cases, millions of participants are involved. This means that researchers can see smaller and smaller effects increasing the number of genes they can link to a disease or trait.
An investigation into one of the current great mysteries of astronomy has come to the fore thanks to a four-year observing campaign conducted at the Jodrell Bank Observatory.
Using the long-term monitoring capabilities of the iconic Lovell Telescope, an international team led by Jodrell Bank astronomers has been studying an object known as a repeating Fast Radio Burst (FRB), which emits very short duration bright radio pulses.
Failure to disclose organizational financial conflicts of interest by producers of Canadian clinical practice guidelines on medications is widespread, pointing to the need for reform, a new research paper highlights in CMAJ (Canadian Medical Association Journal).
Most Canadian guideline producers who make recommendations on medications routinely receive industry funding, including from companies that produce drugs evaluated in the guidelines.
An educational video about hospice care can provide valuable information for patients with advanced cancer and their caregivers, improve perceptions of this quality form of care at the end of life, and increase its use. These are the findings of a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).
The researchers evaluated the NewAccess program, which is an Australian adaptation of the United Kingdom's IAPT (Improving Access to Psychological Therapies) approach of delivering low intensity therapies for symptoms of depression and anxiety - and the results have underlined its effectiveness.
"The timeliness of this study is significant, as its findings tie in to current COVID-19 situation and service delivery," says Professor Michael Baigent, from the Department of Psychiatry at Flinders University.
NEW YORK...June 8, 2020 - Ben-Gurion University of the Negev (BGU) researchers have determined that zero interest rates are more efficient than negative interest rates in terms of motivating individual investors to borrow money and take risks.
"President Trump tweeted in September 2019, 'The Federal Reserve should get our interest rates down to ZERO, or less.' The goal of this paper is to evaluate the impact of zero and negative interest rates on individuals' investment decisions," says Prof. Mosi Rosenboim, of the BGU Guilford Glazer Faculty of Business and Management.
The first-ever detailed study of the diets of great white sharks off the east Australian coast reveals this apex predator spends more time feeding close to the seabed than expected.
"Within the sharks' stomachs we found remains from a variety of fish species that typically live on the seafloor or buried in the sand. This indicates the sharks must spend a good portion of their time foraging just above the seabed," said lead author Richard Grainger, a PhD candidate at the Charles Perkins Centre and School of Life and Environmental Sciences at the University of Sydney.
By delving deeper into metabolism problems, the research team has found that the nutrient sensing capacity of Enterochromaffin (EC) cells - which line the gastrointestinal tract and are the source of almost all serotonin in the body - have changed in mice under the influence of high?fat diet?induced obesity and metabolic disease.
Scientists from the University of Nottingham have developed a new way to control harmful fungi, without the need to use chemical bioactives like fungicides or antifungals.
Fungi cause diverse, serious societal and economic problems in the UK and globally. As well as causing fatal diseases in humans, fungi devastate food crops and spoil valuable products and materials. This has led to an antifungals/fungicide industry worth around $30bn globally.
The clinical presentation of Covid-19 varies from patient to patient and understanding individual genetic susceptibility to the disease is therefore vital to prognosis, prevention, and the development of new treatments. For the first time, Italian scientists have been able to identify the genetic and molecular basis of this susceptibility to infection as well as to the possibility of contracting a more severe form of the disease.
A research team from Genethon, in collaboration with teams from CNRS/Inserm and from the biotechnology company Spark Therapeutics, announced today in Nature Medicine that it has succeeded in inhibiting the immune response induced by AAV antibodies present as a result of natural immunity or following gene therapy, thanks to the IdeS enzyme. This result opens up new therapeutic prospects and the possibility of treating more patients.
n 2017 and 2019, the German Institute for Quality and Efficiency in Health Care (IQWiG) had already examined the advantages and disadvantages of ribociclib in combination with an aromatase inhibitor or fulvestrant in comparison with the appropriate comparator therapy in patients after menopause, with hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer. Since the assessments were based on ongoing studies, the Federal Joint Committee (G-BA) had limited its corresponding decisions.