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ATLANTA--There are common vulnerabilities among three lethal coronaviruses, SARS-CoV-2, SARS-CoV-1 and MERS-CoV, such as frequently hijacked cellular pathways, that could lead to promising targets for broad coronavirus inhibition, according to a study by an international research team that includes scientists from the Institute for Biomedical Sciences at Georgia State University.
NEW YORK, October 15, 2020 -- Aetion co-authored a study published today in Science, which examined lethal coronaviruses SARS-CoV-2, SARS-CoV-1, and MERS-CoV to identify molecular characteristics of potential treatments. The study, which was led by the Quantitative Biosciences Institute at UCSF and involved nearly 200 researchers from leading institutions, applied a novel approach to evaluate molecular hypotheses by analyzing real-world data from COVID-19 patients.
Seeking to inform development of drugs effective against multiple pathogenic human coronaviruses, David E. Gordon and colleagues compared host interactions of MERS-CoV, SARS-CoV-1 and SARS-CoV-2, uncovering host pathways commonly hijacked by all three. Studying patient data showed how COVID-19 patients treated with drugs that acted against selected coronavirus host factors fared, with results that will help guide COVID-19 drug targets, the authors say. SARS-CoV-2, which causes COVID-19, is closely related to the deadly coronaviruses SARS-CoV-1 and MERS-CoV.
By exposing larval zebrafish to a well-known optical illusion, researchers at the Max Planck Institute of Neurobiology and National Institute of Genetics in Japan have found a clever way to isolate key clusters of neurons critical to processing the direction of motion in the zebrafish's environment.
Details were published in the journal Neuron in September 2020.
The findings come from a cross-sectional study, published in BMJ Open, of the comments submitted to the US Food and Drug Administration (FDA) 'Proposed Regulatory Framework for Modifications to Artificial Intelligence/Machine Learning (AI/ML)-Based Software as a Medical Device (SaMD)--Discussion Paper and Request for Feedback'.
Trinity College Dublin researchers have carried out the first multi-centred, international, qualitative study exploring the athlete experience (in their own words) of sporting low back pain (LBP).
LBP is common in rowers and can cause extended time out from the sport and even retirement for some athletes. Rowers from diverse settings (club and university to international standard) in two continents were included in the study.
The findings have been published in the British Journal of Sports Medicine (Thursday, 15th October 2020).
This release has been removed upon request of the submitting institution. Please contact Emma Gaisford, email: emma.gaisford@port.ac.uk, phone number: 02392842897 for more information.
Presently, the moon does not have an internal magnetic field as it can be observed on Earth. However, there are localized regions on its surface up to several hundred kilometers in size where a very strong magnetic field prevails. This has been shown by measurements on rocks from the Apollo missions. Since then, research has puzzled about the origin of these magnetic spots. One theory is that they are in some way remnants of an ancient core magnetic field. Possibly similar to what can still be observed on Earth today.
A rapid and simple method for testing the efficacy of antibacterial drugs on infectious microbes has been developed and validated by a team of Penn State researchers.
Antimicrobial resistant infection is one of the major threats to human health globally, causing 2.5 million infections and 35,000 deaths annually, with the potential to grow to 10 million deaths annually by 2050 without improved techniques for detection and treatment.
(Vienna, 15 October 2020) Poverty is one of the greatest challenges facing humanity. Globally, one out of every 10 people lives in extreme poverty, defined by the World Bank as living on less than $1.90 per day. Many of them live in rural areas where the poverty rate is 17.2 per cent - more than three times higher than in urban areas. If current trends continue, the number of hungry people will reach 840 million or one ninth of the world's population by 2030 according to the World Food Programme.
LONDON, ON - Lawson Health Research Institute and the Centre of Excellence on Post-Traumatic Stress Disorder (PTSD) are partnering with a population at high risk of mental illness - Canadian Veterans and spouses of Canadian Veterans - to study how they have been impacted by the COVID-19 pandemic. Through online surveys, the project will hear directly from Veterans and their spouses to assess the pandemic's effects on their wellbeing over time.
Both seasonal migration and the maintenance and use of an effective immune system come with substantial metabolic costs and are responsible for high levels of oxidative stress. How do animals cope in a situation when energy is limited and both costly body functions are needed? A team of scientists led by the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) investigated whether and how the immune response changes between pre-migration and migration seasons in the Nathusius pipistrelle bat.
REDWOOD CITY, Calif., October 15, 2020 - Synthego, the genome engineering company, has collaborated with The Krogan Lab, a world-renowned scientific research unit at the Quantitative Biosciences Institute (QBI) at the University of California, San Francisco (UCSF), to deliver multiple CRISPR-based engineered cell lines to accelerate the study of potential treatment targets for SARS-CoV-2, the novel coronavirus that causes COVID-19 disease.
Plastic gathered from remote corners of the South Pacific Ocean, including nesting areas of New Zealand albatrosses, has confirmed the global threat of plastic pollution to seabirds.
Published on 12 October in the journal Aquatic Conservation: Marine and Freshwater Ecosystems, the study looks for patterns in the plastics seabirds from around the South Pacific ingest.
It uses data gathered by Canterbury Museum Senior Curator Natural History Dr Paul Scofield and Wellington ornithologist Christopher Robertson in the late 1990s and 2000s.
The number of trees inhabiting the Western Sahara, the Sahel and the Sudanian zone has exceeded the expectations of scientists, with more than 1.8 billion having been located thanks to an international collaboration including researchers from the CNRS*. High-resolution remote sensing made it possible to gather a multitude of satellite images of these areas, which were then analysed by applying an artificial intelligence pattern recognition method.