Combination therapy with both BRAF inhibitor vemurafenib and MEK inhibitor cobimetinib achieves greater progression-free survival and response rates than vemurafenib plus placebo in BRAF-mutation positive melanoma, according to phase III data presented at the ESMO 2014 Congress in Madrid, Spain.
Culture
The tyrosine kinase inhibitor afatinib significantly improved progression-free survival compared to methotrexate in patients with recurrent or metastatic squamous cell carcinoma of the head and neck after failure of platinum-based chemotherapy, the results of a phase III trial show.
Rolapitant reduces nausea and vomiting in patients receiving cisplatin-based chemotherapy, according to the results of a phase III trial presented for the first time today at the ESMO 2014 Congress in Madrid, Spain.
An article released by Social Forces titled, "The Scarring Effects of Primary-Grade Retention? A Study of Cumulative Advantage in the Educational Career" by Megan Andrew explores the effect of scarring in the educational career in the case of primary-grade retention. Just as is the case for labor-market careers, events early in the educational career can leave lasting scars.
Across Europe, more than 70% of young cancer specialists are showing signs of burnout, the largest survey of its kind has revealed. The results, reported at the Congress of the European Society for Medical Oncology (ESMO 2014) in Madrid, have prompted calls for serious action to address the issue at all levels.
"Oncology is an exceptionally rewarding career, but it can be demanding and stressful at times," said Dr Susana Banerjee, lead author of the study and a consultant medical oncologist at The Royal Marsden NHS Trust in London, UK.
NEW BRUNSWICK, N.J. – While the unemployment rate for people out of work for six months or less has returned to prerecession levels, the levels of unemployment for workers who remain jobless for more than six months is among the most persistent, negative effects of the Great Recession, according to a new national study at Rutgers. In fact, one in five workers laid off from a job during the last five years are still unemployed and looking for work, researchers from the John J. Heldrich Center for Workforce Development found.
DURHAM, N.C. -- Coaching patients with chronic obstructive pulmonary disease to manage stress, practice relaxation and participate in light exercise can boost a patient's quality of life and can even improve physical symptoms, researchers at Duke Medicine report.
In a study published online Sept. 25, 2014, in the journal Psychosomatic Medicine, Duke researchers examined how telephone-based coaching could help patients with chronic obstructive pulmonary disease, or COPD, a progressive disease that limits airflow in the lungs.
Geographers at the University of Southampton have developed a new way to measure the 'health' of poor regional communities. They aim to improve the wellbeing of people by guiding sustainable development practices to help avoid social and environmental collapse.
The researchers have pioneered a methodology that examines the balance between factors such as; standards of living, natural resources, agriculture, industry and the economy. The results help identify critical limits, beyond which regions risk tipping into ecological and social downturn, or even collapse.
An anti-inflammatory treatment, studied in the labs of regenerative medicine specialists and trauma surgeons, may prevent what's become one of the war-defining injuries for today's troops.
Those burned by high-velocity explosive devices are at-risk for heterotopic ossification (HO), in which bone develops in places it shouldn't be, outside the skeleton, in joints, muscles and tendons. The painful condition can make it difficult to move and function and commonly affects patients who suffer burns, automobile accidents, orthopedic surgery and blast injuries and other combat wounds.
Osteoarthritis of the hip is a progressive degenerative disorder affecting the hip joints, which affects one in 10 adults. The symptoms range from pain after intense joint loading to morning pain/stiffness and impaired mobility in everyday life. To date, no cure exists. Appropriate exercise therapy can, however, delay progression of the disease and alleviate symptoms, as shown in a randomized controlled study reported by Inga Krauß et al in Deutsches Ärzteblatt (Dtsch Arztebl Int 2014; 111: 592–9).
People working for more than 55 hours per week doing manual work or other low socioeconomic status jobs have a 30% greater risk of developing type 2 diabetes, according to the largest study in this field so far, published in The Lancet Diabetes & Endocrinology.
Mika Kivimäki, Professor of Epidemiology at University College London, UK, and colleagues conducted a systematic review and meta-analysis of published studies and unpublished individual-level data examining the effects of long working hours on type 2 diabetes up to 30 April 2014.
CORAL GABLES, FLORIDA (September 24, 2014) — The challenge and excitement of catching a large fish makes shark fishing very appealing for recreational anglers. However, many species of sharks have experienced population declines due to commercial overfishing. Although generally overlooked by conservation advocates, catch and release shark fishing can provide a strong economic incentive to protect sharks, benefiting both ecotourism businesses and shark conservation.
A new University of Iowa study further supports an inescapable message: caregivers have a profound influence—good or bad—on the emotional state of individuals with Alzheimer's disease. Patients may not remember a recent visit by a loved one or having been neglected by staff at a nursing home, but those actions can have a lasting impact on how they feel.
The findings of this study are published in the September 2014 issue of the journal Cognitive and Behavioral Neurology, and can be viewed online for free here.
ATLANTA—Customers care more about their past experiences with service firms when the economy is doing well, according to a research team from the J. Mack Robinson College of Business at Georgia State University.
HOUSTON – (Sept. 24, 2014) – The cost of monthly premiums for health insurance plans for Texans under the Affordable Care Act (ACA) can vary by hundreds of dollars, depending on a person's income and the level of coverage chosen, according to a report released today by the Episcopal Health Foundation and Rice University's Baker Institute for Public Policy.