1. Sacubitril-valsartan cost-effective for treating reduced ejection fraction heart failure
Abstract: http://www.annals.org/article.aspx?doi=10.7326/M16-0057URLs go live when the embargo lifts
Sacubitril-valsartan is reasonably cost effective compared to widely-used therapies for reducing mortality and morbidity in patients with reduced ejection fraction heart failure. The findings are published in Annals of Internal Medicine.
Chronic fatigue syndrome (CFS) is a mysterious and maddening condition, with no cure or known cause. But researchers at the University of California San Diego School of Medicine, using a variety of techniques to identify and assess targeted metabolites in blood plasma, have identified a characteristic chemical signature for the debilitating ailment and an unexpected underlying biology: It is similar to the state of dauer, and other hypometabolic syndromes like caloric restriction, diapause and hibernation.
New research presented at this year's World Congress of Anaesthesiologists (WCA) in Hong Kong (28 Aug - 2 Sept) shows that patients who have surgery during the night are twice as likely to die as patients operated on during regular working hours. Patients operated on later in the working day or in the early evening also have a higher mortality risk, concludes the study by Dr Michael Tessler, Associate Professor of Anesthesiology, and Dr Ning Nan Wang, Chief Resident, Department of Anesthesia at McGill University Health Centre, Montreal, Canada, and colleagues.
Rome, Italy - 29 Aug.2016: Enhanced cardiac rehabilitation (CR) programs that include a year of group or personal lifestyle and fitness coaching did not improve cardiovascular risk scores more than a standard 3-month program in patients recovering from a heart attack.
ROCHESTER, Minn. - The glucocentric focus on lowering blood sugar in Type 2 diabetes may have short-circuited development of new diabetes therapies, according to a new paper published by Mayo Clinic researchers in the journal Circulation: Cardiovascular Quality and Outcomes.
Recent sociology research at the University of Cincinnati looked closely at the various strategies gay men use to manage both their gendered and sexual identities in the workplace.
Travis Dean Speice, a new sociology doctoral graduate at the University of Cincinnati, says his research indicates that gay men often feel they have to change certain distinct gestures and body language behaviors in order to avoid potential negative consequences from co-workers.
Rome, Italy- 28 August 2016: More than 3 years of nightly treatment with a continuous positive airway pressure (CPAP) machine did not reduce cardiovascular risk more than usual care among patients with cardiovascular disease and obstructive sleep apnea (OSA).
Findings from the Sleep Apnea Cardiovascular Endpoints (SAVE) study were presented at ESC Congress 2016, with simultaneous publication in the New England Journal of Medicine.
Rome, Italy - 28 August, 2016: Placement of an implantable cardioverter-defibrillator (ICD) in patients with non-ischemic systolic heart failure did not improve overall survival compared to usual clinical care - although a secondary outcome, risk of sudden cardiac death, was halved with ICD placement, according to new research reported here.
Rome, Italy - 28 August, 2016: For heart failure patients with cardiac implantable electronic devices (CIEDs), remote monitoring of their condition does not improve outcomes compared to usual care, according to Hot Line results presented at ESC Congress 2016 and to be simultaneously published in JAMA.
Findings from the Remote Management of Heart Failure Using Implantable Electronic Devices (REM-HF) trial showed that remote monitoring was not associated with reduced mortality or fewer cardiovascular hospitalisations compared to usual care.
Rome, Italy - 28 August, 2016: Heart failure patients fitted with biventricular defibrillators (CRT-D) fared no better with remote monitoring (RM) of their condition compared to those whose devices were monitored during in-clinic visits, according to results of the MORE-CARE study.
Rome, Italy - 28 August, 2016: A therapy that uses bone-marrow stem cells to promote heart repair did not significantly improve the primary outcome over a sham procedure among patients with congestive heart failure. However, it revealed critical new insights, according to investigators of the CHART-1 trial.
Rome, Italy - 28 August, 2016: A single dose of mesenchymal stem cells delivered intravenously to patients with chronic non-ischemic cardiomyopathy was not associated with significant cardiac structural or functional improvements, but did result in several clinically relevant benefits, according to results from a phase II-a randomized trial.
A new study suggests gaps exist in the treatment of depression with many individuals who screen positive for the mental health disorder not receiving treatment, according to an article published online by JAMA Internal Medicine.
In a study published online by JAMA, John P. Greenwood, Ph.D., of the University of Leeds, Leeds, United Kingdom, and colleagues examined whether among patients with suspected coronary heart disease (CHD), cardiovascular magnetic resonance (CMR)-guided care is superior to National Institute for Health and Care Excellence (NICE) guidelines-directed care and myocardial perfusion scintigraphy (MPS)-guided care in reducing unnecessary angiography. The study is being released to coincide with its presentation at the European Society of Cardiology Congress 2016.
CHICAGO--August 29, 2016-- An analysis of multicenter randomized controlled clinical trial found osteopathic manipulative treatment (OMT) for pneumonia reduced length of hospital stay in adults 50 to 74 years old and lowered in-hospital mortality rates for patients 75 and older. The study results published in The Journal of the American Osteopathic Association.