Culture

WASHINGTON (July 25, 2019) - Nearly 1,200 child care programs in ten states have improved their healthy eating and physical activity standards after participating in Nemours Children's Health System's National Early Care and Education Learning Collaboratives (NECELC) project, funded by the Centers for Disease Control and Prevention.

A call for a change in the law to class men, forced to have sex with women, as rape victims has been made in a new study by Lancaster University researchers published today.

Men have added their voices to a ground-breaking study - the first of its kind to interview men in the UK - which examines their experience of non-consensual sex with women (known as 'forced to penetrate' cases or FTP).

The term 'forced-to-penetrate' has been coined for these cases because, while they involve non-consensual sex, they do not fall under the offence of rape.

ITHACA, NY, July 22, 2019 - Protecting crops from pests and pathogens without using toxic pesticides has been a longtime goal of farmers. Researchers at Boyce Thompson Institute have found that compounds from an unlikely source - microscopic soil roundworms - could achieve this aim.

Research has long indicated that the elimination of the North American Free Trade Agreement (NAFTA), or simply the withdrawal of the U.S. from NAFTA, would reduce standards of living in Canada, Mexico and the U.S.

A new study from the University of Notre Dame shows the move would indeed economically hurt all three countries, but with a surprising twist -- Canada would suffer the most.

WACO, Texas (July 25, 2019) - Supervisors driven by profits could actually be hurting their coveted bottom lines by losing the respect of their employees, who counter by withholding performance, according to a new study led by Baylor University.

The study, "The Influence of Supervisor Bottom-Line Mentality and Employee Bottom-Line Mentality on Leader-Member Exchange and Subsequent Employee Performance," is published in the journal Human Relations.

Pufferfish are known for their strange and extreme skin ornaments, but how they came to possess the spiky skin structures known as spines has largely remained a mystery. Now, researchers have identified the genes responsible for the evolution and development of pufferfish spines in a study publishing July 25 in the journal iScience. Turns out, the process is pretty similar to how other vertebrates get their hair or feathers--and might have allowed the pufferfish to fill unique ecological niches.

Human artificial chromosomes (HACs) could be useful tools for both understanding how mammalian chromosomes function and creating synthetic biological systems, but for the last 20 years, they have been limited by an inefficient artificial centromere. In the journal Cell on July 25th, researchers announce that they have made progress on this key component.

PITTSBURGH, July 25, 2019 - Pinch yourself. If you feel pain, it's thanks to specialized nerve endings in the skin. And, in a surprising discovery, researchers at the University of Pittsburgh School of Medicine demonstrated that pain-sensing nerves also help fight skin infections and prevent its spread, suggesting a new type of immunity. The findings, based on studies in mice, were published today in the journal Cell.

When metabolism is slowed, fruit flies without any microRNAs survive to become normal adults

Slowed metabolism gives developing organisms time to adjust to mistakes

Study could explain why caloric restriction is linked to longevity and why animals bred for hyper-growth have developmental problems

EVANSTON, Ill. -- Just by slowing their metabolism, mutant fruit flies can go from zero to hero.

Researchers have long known that dozens of inherited diseases, called toxic proteinopathies, are caused by the build-up of specific misfolded proteins in cells. But, the molecular mechanisms responsible for this accumulation have remained a mystery -- hampering efforts to develop therapies.

(PHILADELPHIA) - For the past 20 years, researchers have been trying to perfect the construction of human artificial chromosomes, or HACs for short. In a paper published today in Cell, Penn researchers describe a new way to form an essential part of the artificial chromosome, called the centromere, by bypassing the biological requirements needed to form a natural one. Simply put, they biochemically delivered a protein called CENP-A directly to HAC DNA to simplify the building of a HAC in the lab.

Bottom Line: This research letter reports on the association of BRCA2 gene mutations and potential risk for pediatric or adolescent lymphoma. The study used whole-genome sequencing data for 1,380 survivors of pediatric or adolescent lymphoma (815 survivors of Hodgkin lymphoma and 565 survivors of non-Hodgkin lymphoma), of which 13 survivors had BRCA2 mutations (five survivors of Hodgkin lymphoma and eight survivors of non-Hodgkin lymphoma).

Researchers led by Pierre Vanderhaeghen and Jérôme Bonnefont (VIB-KU Leuven and ULB) have unraveled a new mechanism controlling the switch between growth and differentiation of neural stem cells during brain development. They discovered a specific factor that makes stem cells 'deaf' to proliferative signals, which in turn causes them to differentiate into neurons and shape the marvelous complexity of our brain.

What The Study Did: This observational study examined at what point an increasing number of operations to remove the thyroid performed annually by a surgeon is associated with a lower rate of complications among patients.

Authors: Charles Meltzer, M.D., of the Permanente Medical Group in Santa Rosa, California, is the corresponding author.

(doi:10.1001/jamaoto.2019.1752)

Editor's Note:  Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

A report from St. Jude Children's Research Hospital links inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents. The work appears as an advance online publication today in JAMA Oncology.