Chemokine receptor 4 is a chemokine receptor that participates in tumor occurrence, growth and metastasis in vitro and its expression is upregulated during neuroblastoma metastasis. Dr. Xin Chen, the Affiliated Hospital of Qingdao University, China successfully constructed chemokine receptor 4 sequence-specific small interfering RNA (siRNA) plasmids, transfected into SH-SY5Y cells and found that down-regulation of chemokine receptor 4 can inhibit in vitro invasion of neuroblastoma. This paper was published in Neural Regeneration Research (Vol. 9, No. 10, 2014).Article: " Chemokine receptor 4 gene silencing blocks neuroblastoma metastasis in vitro," by Xin Chen1, Yongjie Zhu1, Lulu Han2, Hongting Lu1, Xiwei Hao1, Qian Dong1 (1 Department of Pediatric Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao, Shandong Province, China; 2 Operating Room, The Affiliated Hospital of QingDao University, Qingdao, Shandong Province, China)Chen X, Zhu YJ, Han LL, Lu HT, Hao XW, Dong Q. Chemokine receptor 4 gene silencing blocks neuroblastoma metastasis in vitro. Neural Regen Res. 2014;9(10):1063-1067.Contact: Meng Zhaoeic@nrren.org86-138-049-98773Neural Regeneration Researchhttp://www.nrronline.org/
A transwell chamber test showed that the metastatic capacity of SH-SY5Y cells was significantly decreased following transfection with chemokine receptor 4-specific small interfering RNA (optical microscope, ×100).
(Photo Credit: Neural Regeneration Research)
Source: Neural Regeneration Research